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Fancc
Gene Detail
Symbol

Name
ID
Fancc
Fanconi anemia, complementation group C
MGI:95480
Synonyms
Facc
Feature Type
protein coding gene
Genetic Map
Chromosome 13
32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:63304709-63497278 bp, - strand
From VEGA annotation of GRCm38

  192570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FANCC
Protein SuperFamily: Fanconi anemia group C protein
Gene Tree: Fancc

Human
homologs
FANCC, Fanconi anemia, complementation group C
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2176
neXtProt AC: NX_Q00597

Human Synonyms: FA3, FAC, FACC

Human Chr (Location): 9q22.3; chr9:95099054-95317709 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FANCC

Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants are grossly normal, but chromosome aberrations and sensitivity to DNA crosslinkers are seen. Both sexes have fewer germ cell numbers and impaired fertility. Marrow progenitors show decrease in colony forming ability.
 
Human Diseases Modeled in Mice Using Fancc (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Fancc interacts with 159 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process activation of mitophagy in response to mitochondrial depolarization, cellular response to DNA damage stimulus, ...
Component chromatin, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (25)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 35
RT-PCR 11
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fancc ; ZFIN fancc    NEW 
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000030853 (Evidence)
Ensembl Gene Model ENSMUSG00000021461 (Evidence)
Entrez Gene 14088 (Evidence)
DFCI TC1579449, TC1588260, TC1590121, TC1611483, TC1618345, TC1669468
DoTS DT.101217724, DT.531671, DT.55157417, DT.91324000, DT.91326121, DT.94159665, DT.97387561
Consensus CDS Project CCDS36700.1, CCDS70472.1
International Mouse Phenotyping Consortium Status Fancc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030853 VEGA Gene Model | MGI Sequence Detail 192570 C57BL/6J ±  kb
transcript OTTMUST00000076339 VEGA | MGI Sequence Detail 2995 Not Applicable 
polypeptide OTTMUSP00000040172 VEGA | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(138) RefSeq(40) UniProt(12)
Polymorphisms
RFLP(2) : SNPs within 2kb(1338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000686 Fanconi anaemia group C protein
Protein Ontology PR:000007332 Fanconi anemia group C protein
References
(Earliest) J:1087 Strathdee CA, et al., Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat Genet. 1992 Jun;1(3):196-8
(Latest) J:218118 Larin M, et al., Fanconi anemia signaling and Mus81 cooperate to safeguard development and crosslink repair. Nucleic Acids Res. 2014 Sep;42(15):9807-20
All references(84)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-9707, MGI:2145472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory