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Fancc
Gene Detail
 Symbol
Name
ID
Fancc
Fanconi anemia, complementation group C
MGI:95480
Synonyms Facc
Feature Type protein coding gene
Genetic Map
Chromosome 13
32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr13:63304709-63497278 bp, - strand
From VEGA annotation of GRCm38

  192570 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Fanconi anemia group C protein
Gene Tree: Fancc

Human
homologs
Human Homolog FANCC, Fanconi anemia, complementation group C
NCBI Gene ID 2176
neXtProt AC  NX_Q00597
Human Synonyms  FA3, FAC, FACC
Human Chr (Location)  9q22.3; chr9:95099054-95317709 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FANCC
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are grossly normal, but chromosome aberrations and sensitivity to DNA crosslinkers are seen. Both sexes have fewer germ cell numbers and impaired fertility. Marrow progenitors show decrease in colony forming ability.
 
Human Diseases Modeled Using Mouse Fancc (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Fancc interacts with 159 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cellular response to DNA damage stimulus, DNA repair, ...
Component chromatin, cytoplasm, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (25)    Images (15)
Theiler Stages: 19, 20, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 35
RT-PCR 11
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) Genomic(1) cDNA(52) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000030853 (Evidence)
Ensembl Gene ModelENSMUSG00000021461 (Evidence)
Entrez Gene14088 (Evidence)
UniGene126106
DFCITC1579449, TC1588260, TC1590121, TC1611483, TC1618345, TC1669468
DoTSDT.101217724, DT.531671, DT.55157417, DT.91324000, DT.91326121, DT.94159665, DT.97387561
NIA Mouse Gene IndexU034897
Consensus CDS ProjectCCDS36700.1, CCDS70472.1
International Mouse Knockout Project StatusFancc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030853 VEGA Gene Model | MGI Sequence Detail 192570 C57BL/6J ±  kb
transcript OTTMUST00000076339 VEGA | MGI Sequence Detail 2995 Not Applicable 
polypeptide OTTMUSP00000040172 VEGA | MGI Sequence Detail 591 Not Applicable 

For the selected sequences
All sequences(128) RefSeq(30) UniProt(12)
Polymorphisms RFLP(2) : SNPs within 2kb(1338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000686 Fanconi anaemia group C protein
Protein Ontology PR:000007332 Fanconi anemia group C protein
References (Earliest) J:1087 Strathdee CA, et al., Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat Genet. 1992 Jun;1(3):196-8
(Latest) J:211173 Luebben SW, et al., Helq acts in parallel to Fancc to suppress replication-associated genome instability. Nucleic Acids Res. 2013 Dec;41(22):10283-97
All references(86)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-9707, MGI:2145472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory