Fancc
Gene Detail

Symbol Name ID

Fancc Fanconi anemia, complementation group C MGI:95480

Synonyms

Facc

Feature Type

protein coding gene

Genetic Map

Chromosome 13

32.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr13:63304709-63497278 bp, - strand From VEGA annotation of GRCm38   192570 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:109  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Fanconi anemia group C protein
Gene Tree: Fancc

Human homologs

Human Homolog		FANCC, Fanconi anemia, complementation group C
NCBI Gene ID		2176
neXtProt AC		NX_Q00597
Human Synonyms		FA3, FAC, FACC
Human Chr (Location)		9q22.3; chr9:97861336-98079991 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human FANCC

Alleles and phenotypes

All alleles(38) : Targeted(4) Gene trapped(34)
 

Homozygous null mutants are grossly normal, but chromosome aberrations and sensitivity to DNA crosslinkers are seen. Both sexes have fewer germ cell numbers and impaired fertility. Marrow progenitors show decrease in colony forming ability.

 
Human Diseases Modeled Using Mouse Fancc (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	DNA repair, gamete generation, ...
Component	chromatin, cytoplasm, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (46)    Tissues (24)    Images (15)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	35
RT-PCR	11

cDNA source data(51)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(55) Genomic(1) cDNA(52) Primer pair(1) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000030853 (Evidence)
Ensembl Gene Model	ENSMUSG00000021461 (Evidence)
Entrez Gene	14088 (Evidence)
UniGene	126106
DFCI	TC1579449, TC1588260, TC1590121, TC1611483, TC1618345
DoTS	DT.101217724, DT.531671, DT.55157417, DT.91324000, DT.91326121, DT.94159665, DT.97387561
NIA Mouse Gene Index	U034897
Consensus CDS Project	CCDS36700.1
International Mouse Knockout Project Status	Fancc

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030853	VEGA Gene Model | MGI Sequence Detail	192570	C57BL/6J
transcript	OTTMUST00000076339	VEGA | MGI Sequence Detail	2995	Not Applicable
polypeptide	OTTMUSP00000040172	VEGA | MGI Sequence Detail	591	Not Applicable

All sequences(100) RefSeq(4) UniProt(12)

Polymorphisms

RFLP(2) : SNPs(776 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000686	Fanconi anaemia group C protein
Protein Ontology	PR:000007332	Fanconi anemia group C protein

References

(Earliest) J:1087 Strathdee CA, et al., Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9. Nat Genet. 1992 Jun;1(3):196-8
(Latest) J:186574 Muller LU, et al., Overcoming reprogramming resistance of Fanconi anemia cells. Blood. 2012 Jun 7;119(23):5449-57
All references(81)

Other accession IDs

MGD-MRK-9707, MGI:2145472