About   Help   FAQ
Fabp1 Gene Detail
Summary
  • Symbol
    Fabp1
  • Name
    fatty acid binding protein 1, liver
  • Synonyms
    Fabpl, L-FABP, MGC:13855
  • Feature Type
    protein coding gene
  • IDs
    MGI:95479
    NCBI Gene: 14080
  • Gene Overview
    MyGene.info: FABP1
Location & Maps
more
  • Sequence Map
    Chr6:71199827-71205023 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5197 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.14 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    FABP1, fatty acid binding protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FABP1, fatty acid binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FABPL, L-FABP
  • Links
    NCBI Gene ID: 2168
    neXtProt AC: NX_P07148

  • Chr Location
    2p11; chr2:88122982-88128131 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene do not show any obvious morphological, behavioral, or reproductive abnormalities. Changes may be observed in lipid composition, lipid binding, or levels of lipid binding proteins.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023123 VEGA Gene Model | MGI Sequence Detail 5197 C57BL/6J ±  kb
transcript OTTMUST00000055875 VEGA | MGI Sequence Detail 553 Not Applicable  
polypeptide OTTMUSP00000026804 VEGA | MGI Sequence Detail 127 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    41 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 125
    cDNA 122
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9706
References
more
  • Summaries
    All 95
    Developmental Gene Expression 23
    Gene Ontology 8
    Phenotypes 36
  • Earliest
    J:8932 Sweetser DA, et al., The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol Chem. 1987 Nov 25;262(33):16060-71
  • Latest
    J:230775 Martin GG, et al., Loss of L-FABP, SCP-2/SCP-x, or both induces hepatic lipid accumulation in female mice. Arch Biochem Biophys. 2015 Aug 15;580:41-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory