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Fabp1
Gene Detail
 Symbol
Name
ID
Fabp1
fatty acid binding protein 1, liver
MGI:95479
Synonyms Fabpl, L-FABP, MGC:13855
Feature Type protein coding gene
Genetic Map
Chromosome 6
32.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:71199827-71205023 bp, + strand
From VEGA annotation of GRCm38

  5197 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1106  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: lipid binding protein, FABP type
Gene Tree: Fabp1

Human
homologs
Human Homolog FABP1, fatty acid binding protein 1, liver
NCBI Gene ID 2168
neXtProt AC  NX_P07148
Human Synonyms  FABPL, L-FABP
Human Chr (Location)  2p11; chr2:88122982-88128131 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene do not show any obvious morphological, behavioral, or reproductive abnormalities. Changes may be observed in lipid composition, lipid binding, or levels of lipid binding proteins.
 
Interactions
Fabp1 interacts with 8 markers (Mir302b, Mir302d, Mir325, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular response to hydrogen peroxide, cellular response to hypoxia, ...
Component apical cortex, cytoplasm, ...
Function antioxidant activity, bile acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (5)    Tissues (4)   
Theiler Stages: 21, 23, 25
Assay TypeResults
RT-PCR 5
cDNA source data(120)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(122) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023123 (Evidence)
Ensembl Gene ModelENSMUSG00000054422 (Evidence)
Entrez Gene14080 (Evidence)
UniGene22126
DFCITC1575046
DoTSDT.495164
NIA Mouse Gene IndexU007013
Consensus CDS ProjectCCDS20226.1
International Mouse Knockout Project StatusFabp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023123 VEGA Gene Model | MGI Sequence Detail 5197 C57BL/6J ±  kb
transcript OTTMUST00000055875 VEGA | MGI Sequence Detail 553 Not Applicable 
polypeptide OTTMUSP00000026804 VEGA | MGI Sequence Detail 127 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012674 Calycin
InterPro IPR011038 Calycin-like
InterPro IPR000463 Cytosolic fatty-acid binding
InterPro IPR000566 Lipocalin/cytosolic fatty-acid binding protein domain
Protein Ontology PR:000007309 fatty acid-binding protein, liver
References (Earliest) J:8932 Sweetser DA, et al., The human and rodent intestinal fatty acid binding protein genes. A comparative analysis of their structure, expression, and linkage relationships. J Biol Chem. 1987 Nov 25;262(33):16060-71
(Latest) J:210241 Ong KT, et al., Hepatic ATGL mediates PPAR-alpha signaling and fatty acid channeling through an L-FABP independent mechanism. J Lipid Res. 2014 May;55(5):808-15
All references(90)
Other
accession IDs
MGD-MRK-9706

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory