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Evx2 Gene Detail
Summary
  • Symbol
    Evx2
  • Name
    even-skipped homeobox 2
  • Synonyms
    Evx-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95462
    NCBI Gene: 14029
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:74652991-74659557 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 44.13 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95462
protein coding gene Chr2:74652989-74661520 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025844
protein coding gene Chr2:74966751-74973195 (-)
A/J MGP_AJ_G0025822
protein coding gene Chr2:72034271-72040831 (-)
AKR/J MGP_AKRJ_G0025790
protein coding gene Chr2:73987218-73993783 (-)
BALB/cJ MGP_BALBcJ_G0025816
protein coding gene Chr2:72221249-72227814 (-)
C3H/HeJ MGP_C3HHeJ_G0025576
protein coding gene Chr2:74175291-74181980 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026263
protein coding gene Chr2:77200729-77207989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023666
protein coding gene Chr2:69457278-69463834 (-)
CAST/EiJ MGP_CASTEiJ_G0025040
protein coding gene Chr2:74482231-74490465 (-)
CBA/J MGP_CBAJ_G0025557
protein coding gene Chr2:80019589-80026151 (-)
DBA/2J MGP_DBA2J_G0025688
protein coding gene Chr2:71641352-71647710 (-)
FVB/NJ MGP_FVBNJ_G0025650
protein coding gene Chr2:71027880-71036840 (-)
LP/J MGP_LPJ_G0025776
protein coding gene Chr2:74831467-74838050 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025681
protein coding gene Chr2:81934015-81941150 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026320
protein coding gene Chr2:74101346-74107912 (-)
PWK/PhJ MGP_PWKPhJ_G0024781
protein coding gene Chr2:71570517-71577088 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024589
protein coding gene Chr2:74336795-74343351 (-)
WSB/EiJ MGP_WSBEiJ_G0025108
protein coding gene Chr2:74537836-74544392 (-)



Homology
more
  • Human Ortholog
    EVX2, even-skipped homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EVX2, even-skipped homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EVX-2
  • Links
    NCBI Gene ID: 344191
    neXtProt AC: NX_Q03828
    UniProt: Q03828

  • Chr Location
    2q31.1; chr2:176080107-176083962 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 74879
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EVX2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased body weight, male infertility, short limbs, and abnormalities in phalanx, carpal bone and metacarpal bone morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001815 Ensembl Gene Model | MGI Sequence Detail 6567 C57BL/6J ±  kb
    transcript ENSMUST00000173623 Ensembl | MGI Sequence Detail 1428 Not Applicable  
    polypeptide ENSMUSP00000134131 Ensembl | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 10
      cDNA 15
      Primer pair 4
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9675, MGD-MRK-9677
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 42
      Gene Ontology 5
      Phenotypes 28
    • Earliest
      J:10491 Davisson MT, et al., The mouse mutation ulnaless on chromosome 2. J Hered. 1990 Mar-Apr;81(2):151-3
    • Latest
      J:283226 Desiderio S, et al., Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA. Cell Rep. 2019 Mar 26;26(13):3522-3536.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    02/23/2021
    MGI 6.16
    The Jackson Laboratory