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Evx1
Gene Detail
Symbol

Name
ID
Evx1
even skipped homeotic gene 1 homolog
MGI:95461
Synonyms
Evx-1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
25.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:52313498-52318378 bp, + strand
From VEGA annotation of GRCm38

  4881 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1507  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EVX1
Gene Tree: Evx1

Human
homologs
EVX1, even-skipped homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2128
neXtProt AC: NX_P49640

Human Synonyms: EVX-1

Human Chr (Location): 7p15.2; chr7:27242545-27247819 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from CvDC )
 
Homozygotes for a particular targeted mutation are embryonic lethal. Another heritable cre-generated allele exhibits defects of the interneurons of the ventral spinal cord, and rarely, a kinked tail.
 
Interactions
Evx1 interacts with 211 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process embryo development ending in birth or egg hatching, multicellular organismal development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (95 records)
Data Summary: Results (313)    Tissues (157)    Images (93)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 311
Northern blot 1
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EVX1 ; Xenbase evx1 ; ZFIN evx1    NEW 
Molecular
reagents
All nucleic(24) Genomic(7) cDNA(9) Primer pair(1) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018871 (Evidence)
Ensembl Gene Model ENSMUSG00000005503 (Evidence)
Entrez Gene 14028 (Evidence)
UniGene 389754
DFCI TC1595533
DoTS DT.55206146
NIA Mouse Gene Index U006872
Consensus CDS Project CCDS20149.1
International Mouse Phenotyping Consortium Status Evx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018871 VEGA Gene Model | MGI Sequence Detail 4881 C57BL/6J ±  kb
transcript OTTMUST00000045392 VEGA | MGI Sequence Detail 2877 Not Applicable 
polypeptide OTTMUSP00000020421 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(3)
Polymorphisms
All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs within 2kb(7 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007241 homeobox even-skipped homolog protein 1
References
(Earliest) J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
(Latest) J:217063 Zou M, et al., Selective neuronal lineages derived from Dll4-expressing progenitors/precursors in the retina and spinal cord. Dev Dyn. 2015 Jan;244(1):86-97
All references(120)
Other
accession IDs
MGD-MRK-9674, MGD-MRK-9676

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory