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Etl4 Gene Detail
Summary
  • Symbol
    Etl4
  • Name
    enhancer trap locus 4
  • Synonyms
    6620402G01Rik, 9430077C05Rik, E330027G05Rik, Etl-4, Sickle tail, Skt
  • Feature Type
    protein coding gene
  • IDs
    MGI:95454
    NCBI Gene: 208618
Location & Maps
more
  • Sequence Map
    Chr2:19909780-20810713 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      900934 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 14.27 cM, cytoband A3
  • Mapping Data
    6 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    KIAA1217, KIAA1217
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIAA1217, KIAA1217
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SKT
  • Links
    NCBI Gene ID: 56243
    neXtProt AC: NX_Q5T5P2

  • Chr Location
    10p12.2-p12.1; chr10:23694746-24547848 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 10477
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KIAA1217
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 4 genetic backgrounds
    20 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele display malformations of the notochord and caudal vertebrae and may exhibit caudal tail kinks. Mice homozygous for another gene-trapped allele have malformed caudal vertebrae and intervertebral disk abnormalities; about half display kinked tails.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011450 VEGA Gene Model | MGI Sequence Detail 900934 C57BL/6J ±  kb
transcript OTTMUST00000026842 VEGA | MGI Sequence Detail 7197 Not Applicable  
polypeptide OTTMUSP00000012256 VEGA | MGI Sequence Detail 1946 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6193 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    9 Sequences
  • InterPro Domains
    IPR022782 Actin interacting protein 3, C-terminal
    IPR026725 Sickle tail protein
Molecular
Reagents
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  • All nucleic 26
    cDNA 21
    Primer pair 3
    Other 2

    Microarray probesets 9
Other
Accession IDs
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MGD-MRK-9659, MGD-MRK-9662, MGI:1922998, MGI:1924547, MGI:2384779, MGI:2442648
References
more
  • Summaries
    All 49
    Developmental Gene Expression 11
    Gene Ontology 3
    Phenotypes 18
  • Earliest
    J:14930 O'Kane CJ, et al., Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9123-7
  • Latest
    J:229383 Serth K, et al., Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination. BMC Genet. 2015;16:143

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory