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Smarcad1
Gene Detail
 Symbol
Name
ID
Smarcad1
SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
MGI:95453
Synonyms D6Pas1, Etl1, mKIAA1122
Feature Type protein coding gene
Genetic Map
Chromosome 6
30.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr6:65042667-65116049 bp, + strand
From NCBI annotation of GRCm38

  73383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5301  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Smarcad1

Human
homologs
Human Homolog SMARCAD1, SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
NCBI Gene ID 56916
neXtProt AC  NX_Q9H4L7
Human Synonyms  ADERM, ETL1, HEL1
Human Chr (Location)  4q22-q23; chr4:94207608-94291292 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SMARCAD1
Mutations,
alleles, and
phenotypes
All mutations/alleles(317) : Gene trapped(313) Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygotes for a targeted null mutation exhibit retarded growth, impaired fertility, skeletal dysplasias, and peri- and postnatal lethality. Mutant phenotypes are influenced by genetic background.
 
Interactions
Smarcad1 interacts with 346 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process ATP-dependent chromatin remodeling, cellular response to DNA damage stimulus, ...
Component chromosome, heterochromatin, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (252)    Tissues (118)    Images (12)
Theiler Stages: 2, 3, 16, 20, 23, 26, 28
Assay TypeResults
RNA in situ 124
In situ reporter (knock in) 92
RT-PCR 36
cDNA source data(153)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(160) Genomic(1) cDNA(157) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029920 (Evidence)
Entrez Gene13990 (Evidence)
UniGene99113
DFCITC1577390, TC1597073, TC1604618, TC1622237
DoTSDT.101380956, DT.529694, DT.91289950, DT.91446986
EC3.6.4.12
Consensus CDS ProjectCCDS20204.1
International Mouse Knockout Project StatusSmarcad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13990 NCBI Gene Model | MGI Sequence Detail 73383 C57BL/6J ±  kb
transcript NM_007958 RefSeq | MGI Sequence Detail 5098 C57BL/6 
polypeptide Q04692 UniProt | EBI | MGI Sequence Detail 1021 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(15) UniProt(1)
Polymorphisms SNPs within 2kb(190 from dbSNP Build 137)    SNPs within 2kb including multiple locations(196)
Protein-related
information
ResourceIDDescription
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000330 SNF2-related
InterPro IPR003892 Ubiquitin system component Cue
Protein Ontology PR:000032458 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1
Graphical View of Protein Domain Structure
References (Earliest) J:14930 O'Kane CJ, et al., Detection in situ of genomic regulatory elements in Drosophila. Proc Natl Acad Sci U S A. 1987 Dec;84(24):9123-7
(Latest) J:183196 Rowbotham SP, et al., Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1. Mol Cell. 2011 May 6;42(3):285-96
All references(49)
Other
accession IDs
MGD-MRK-7699, MGD-MRK-9660, MGI:2141618, MGI:2141670, MGI:93794

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory