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Ces1e
Gene Detail
Symbol

Name
ID
Ces1e
carboxylesterase 1E
MGI:95432
Synonyms
Eg, egasyn, Es22, Es-22
Feature Type
protein coding gene
Genetic Map
Chromosome 8
45.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr8:93201218-93229619 bp, - strand
From VEGA annotation of GRCm38

  28402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115660  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque

Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Ces1e

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Spontaneous(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation lack stable microsomal beta-glucuronidase and display altered processing of lysosomal beta-glucuronidase in liver.
 
Interactions
Ces1e interacts with 37 markers (Mir17, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process metabolic process
Component endoplasmic reticulum
Function carboxylic ester hydrolase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (115)    Tissues (96)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 115
cDNA source data(27)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(28) cDNA(28)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024535 (Evidence)
Ensembl Gene ModelENSMUSG00000061959 (Evidence)
Entrez Gene13897 (Evidence)
UniGene63490
DFCITC1583299
DoTSDT.481998
NIA Mouse Gene IndexU030102
EC3.1.1.1
Consensus CDS ProjectCCDS22529.1
International Mouse Knockout Project StatusCes1e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024535 VEGA Gene Model | MGI Sequence Detail 28402 C57BL/6J ±  kb
transcript OTTMUST00000060221 VEGA | MGI Sequence Detail 2073 Not Applicable 
polypeptide OTTMUSP00000029366 VEGA | MGI Sequence Detail 562 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(267 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019826 Carboxylesterase type B, active site
InterPro IPR019819 Carboxylesterase type B, conserved site
Protein Ontology PR:000007291 liver carboxylesterase 22
References
(Earliest) J:5051 Ganschow R, et al., Separate genes determining the structure and intracellular location of hepatic glucuronidase. Proc Natl Acad Sci U S A. 1967 Sep;58(3):938-45
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(52)
Other
accession IDs
MGD-MRK-9314, MGD-MRK-9602, MGD-MRK-9634

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory