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Ces1e Gene Detail
Summary
  • Symbol
    Ces1e
  • Name
    carboxylesterase 1E
  • Synonyms
    Eg, egasyn, Es22, Es-22
  • Feature Type
    protein coding gene
  • IDs
    MGI:95432
    NCBI Gene: 13897
  • Member of
    Ces1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr8:93927846-93956233 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 45.11 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    267 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95432
 protein coding gene Chr8:93927846-93956247 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033944
 protein coding gene Chr8:94571661-94603146 (-)
A/J MGP_AJ_G0033927
 protein coding gene Chr8:90870240-90899972 (-)
AKR/J MGP_AKRJ_G0033853
 protein coding gene Chr8:93369737-93400785 (-)
BALB/cJ MGP_BALBcJ_G0033919
 protein coding gene Chr8:90973524-91002243 (-)
C3H/HeJ MGP_C3HHeJ_G0033629
 protein coding gene Chr8:94073669-94105572 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034440
 protein coding gene Chr8:98005413-98035916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031381
 protein coding gene Chr8:84719144-84747401 (-)
CAST/EiJ MGP_CASTEiJ_G0032961
 protein coding gene Chr8:93645479-93675763 (-)
CBA/J MGP_CBAJ_G0033605
 protein coding gene Chr8:101276459-101311142 (-)
DBA/2J MGP_DBA2J_G0033759
 protein coding gene Chr8:90359740-90388303 (-)
FVB/NJ MGP_FVBNJ_G0033706
 protein coding gene Chr8:89316749-89346365 (-)
LP/J MGP_LPJ_G0033851
 protein coding gene Chr8:94696472-94736477 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033748
 protein coding gene Chr8:103603699-103634960 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034458
 protein coding gene Chr8:93511885-93540659 (-)
PWK/PhJ MGP_PWKPhJ_G0032663
 protein coding gene Chr8:89709398-89738380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032500
 protein coding gene Chr8:92360277-92394125 (-)
WSB/EiJ MGP_WSBEiJ_G0033073
 protein coding gene Chr8:93949534-93980908 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES1, carboxylesterase 1
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833337 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CES1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a spontaneous mutation lack stable microsomal beta-glucuronidase and display altered processing of lysosomal beta-glucuronidase in liver.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    96
  • cDNA Data
    27
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13897 NCBI Gene Model | MGI Sequence Detail 28388 C57BL/6J ±  kb
transcript NM_133660 RefSeq | MGI Sequence Detail 2059 ZRU/MplStud  
polypeptide Q64176 UniProt | EBI | MGI Sequence Detail 562 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    cDNA 28

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9314, MGD-MRK-9602, MGD-MRK-9634
References
more
  • Summaries
    All 53
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:5051 Ganschow R, et al., Separate genes determining the structure and intracellular location of hepatic glucuronidase. Proc Natl Acad Sci U S A. 1967 Sep;58(3):938-45
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory