Ces1c
Gene Detail

Symbol Name ID

Ces1c carboxylesterase 1C MGI:95420

Synonyms

Ces-N, Ee-1, Es1, Es-1, Es-4, Es-N

Feature Type

protein coding gene

Genetic Map

Chromosome 8

44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(114)

Sequence Map

Chr8:93099015-93131283 bp, - strand From VEGA annotation of GRCm38   32269 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:117484  Vertebrate Homology Class
2 mouse

Protein SuperFamily: esterase, acetylcholinesterase type
Gene Tree: Ces1c

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit protection against nerve agents such as chlorpyrifos and chlorpyrifos oxon but increased sensitivity to soman coumarin.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	metabolic process
Component	endoplasmic reticulum, extracellular space
Function	carboxylesterase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (95)    Images (15)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	102

cDNA source data(156)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(159) cDNA(157) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000024453 (Evidence)
Ensembl Gene Model	ENSMUSG00000057400 (Evidence)
Entrez Gene	13884 (Evidence)
UniGene	88078
NIA Mouse Gene Index	U030099
EC	3.1.1.1
Consensus CDS Project	CCDS22527.1
International Mouse Knockout Project Status	Ces1c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024453	VEGA Gene Model | MGI Sequence Detail	32269	C57BL/6J
transcript	OTTMUST00000059971	VEGA | MGI Sequence Detail	1828	Not Applicable
polypeptide	OTTMUSP00000029223	VEGA | MGI Sequence Detail	554	Not Applicable

All sequences(26) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(8) : SNPs(223 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002018	Carboxylesterase, type B
InterPro	IPR019826	Carboxylesterase type B, active site
InterPro	IPR019819	Carboxylesterase type B, conserved site
Protein Ontology	PR:000007290	liver carboxylesterase N

References

(Earliest) J:13081 POPP RA, et al., Inheritance of serum esterases having different electrophoretic patterns. J Hered. 1962 May-Jun;53:111-4
(Latest) J:174614 Duysen EG, et al., Induction of plasma acetylcholinesterase activity in mice challenged with organophosphorus poisons. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):214-20
All references(127)

Other accession IDs

MGD-MRK-9303, MGD-MRK-9588, MGD-MRK-9613, MGD-MRK-9620, MGD-MRK-9621