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Eno2 Gene Detail
Summary
  • Symbol
    Eno2
  • Name
    enolase 2, gamma neuronal
  • Synonyms
    D6Ertd375e, Eno-2, NSE
  • Feature Type
    protein coding gene
  • IDs
    MGI:95394
    NCBI Gene: 13807
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124737016-124746636 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95394
protein coding gene Chr6:124737016-124746636 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031266
protein coding gene Chr6:128064479-128073819 (-)
A/J MGP_AJ_G0031236
protein coding gene Chr6:123251092-123260715 (-)
AKR/J MGP_AKRJ_G0031164
protein coding gene Chr6:126609668-126619291 (-)
BALB/cJ MGP_BALBcJ_G0031244
protein coding gene Chr6:122850804-122860192 (-)
C3H/HeJ MGP_C3HHeJ_G0030967
protein coding gene Chr6:126660981-126670406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031700
protein coding gene Chr6:131453802-131463370 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028850
protein coding gene Chr6:120438364-120447629 (-)
CAST/EiJ MGP_CASTEiJ_G0030348
protein coding gene Chr6:126862870-126873723 (-)
CBA/J MGP_CBAJ_G0030928
protein coding gene Chr6:136482958-136493495 (-)
DBA/2J MGP_DBA2J_G0031084
protein coding gene Chr6:122176527-122185858 (-)
FVB/NJ MGP_FVBNJ_G0031034
protein coding gene Chr6:121080545-121089763 (-)
LP/J MGP_LPJ_G0031164
protein coding gene Chr6:128240354-128250085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031072
protein coding gene Chr6:140537065-140547002 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031735
protein coding gene Chr6:126501172-126510554 (-)
PWK/PhJ MGP_PWKPhJ_G0030063
protein coding gene Chr6:120404966-120415026 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029892
protein coding gene Chr6:124578688-124588914 (-)
WSB/EiJ MGP_WSBEiJ_G0030433
protein coding gene Chr6:126862405-126873110 (-)



Homology
more
  • Human Ortholog
    ENO2, enolase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ENO2, enolase 2
  • Synonyms
    HEL-S-279, NSE
  • Links
    NCBI Gene ID: 2026
    neXtProt AC: NX_P09104
    UniProt: P09104

  • Chr Location
    12p13.31; chr12:6914450-6923696 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human ENO2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from multigenic genotypes
    1 images
    24 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13807 NCBI Gene Model | MGI Sequence Detail 9621 C57BL/6J ±  kb
transcript NM_001409688 RefSeq | MGI Sequence Detail 3219 C57BL/6  
polypeptide P17183 UniProt | EBI | MGI Sequence Detail 434 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    Genomic 4
    cDNA 76
    Primer pair 7

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-9504, MGD-MRK-9507, MGI:1196312, MGI:2141477
References
more
  • Summaries
    All 103
    Developmental Gene Expression 44
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:8559 Lazar M, et al., Isolation of murine neuron-specific and non-neuronal enolase cDNA clones. Biochem Biophys Res Commun. 1986 Nov 26;141(1):271-7
  • Latest
    J:305273 Matsuo T, et al., Thiazoline-related innate fear stimuli orchestrate hypothermia and anti-hypoxia via sensory TRPA1 activation. Nat Commun. 2021 Apr 6;12(1):2074

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory