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Eno1 Gene Detail
Summary
  • Symbol
    Eno1
  • Name
    enolase 1, alpha non-neuron
  • Synonyms
    2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, Eno-1, MBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95393
    NCBI Gene: 13806
  • Gene Overview
    MyGene.info: ENO1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:150236721-150248879 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12159 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 81.24 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ENO1, enolase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENO1, enolase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ENO1L1, HEL-S-17, MPB1, NNE, PPH
  • Links
    NCBI Gene ID: 2023
    neXtProt AC: NX_P06733
    UniProt: P06733

  • Chr Location
    1p36.23; chr1:8861000-8879092 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 134343
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ENO1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous animals exhibit growth arrest and embryonic lethality at approximately E6.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010390 VEGA Gene Model | MGI Sequence Detail 12159 C57BL/6J ±  kb
    transcript OTTMUST00000024224 VEGA | MGI Sequence Detail 2027 Not Applicable  
    polypeptide OTTMUSP00000011140 VEGA | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      139 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 1
      cDNA 32
      Primer pair 1
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-9503, MGD-MRK-9506, MGI:2143710
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 20
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:5856 D'Ancona GG, et al., Assignment of the gene for enolase to mouse chromosome 4 using somatic cell hybrids. Cytogenet Cell Genet. 1977;19(1):1-6
    • Latest
      J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory