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Eno1 Gene Detail
Summary
  • Symbol
    Eno1
  • Name
    enolase 1, alpha non-neuron
  • Synonyms
    2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, Eno-1, MBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95393
    NCBI Gene: 13806
  • Gene Overview
    MyGene.info: ENO1
Location & Maps
more
  • Sequence Map
    Chr4:150236721-150248879 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12159 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 81.24 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    ENO1, enolase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENO1, enolase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ENO1L1, HEL-S-17, MPB1, NNE, PPH
  • Links
    NCBI Gene ID: 2023
    neXtProt AC: NX_P06733

  • Chr Location
    1p36.2; chr1:8861000-8879092 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 134343
    1 human;2 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ENO1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    83
  • Gene trapped
    81
  • Targeted
    2
  • Genomic Mutations
    1 involving Eno1
  • Incidental Mutations
Homozygous animals exhibit growth arrest and embryonic lethality at approximately E6.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010390 VEGA Gene Model | MGI Sequence Detail 12159 C57BL/6J ±  kb
transcript OTTMUST00000024224 VEGA | MGI Sequence Detail 2027 Not Applicable  
polypeptide OTTMUSP00000011140 VEGA | MGI Sequence Detail 434 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    139 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    Genomic 1
    cDNA 32
    Primer pair 1
    Other 2

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-9503, MGD-MRK-9506, MGI:2143710
References
more
  • Summaries
    All 65
    Developmental Gene Expression 17
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:5856 D'Ancona GG, et al., Assignment of the gene for enolase to mouse chromosome 4 using somatic cell hybrids. Cytogenet Cell Genet. 1977;19(1):1-6
  • Latest
    J:228857 Zhu X, et al., A gain-of-function mutation in Tnni2 impeded bone development through increasing Hif3a expression in DA2B mice. PLoS Genet. 2014 Oct;10(10):e1004589

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory