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Eno1 Gene Detail
Summary
  • Symbol
    Eno1
  • Name
    enolase 1, alpha non-neuron
  • Synonyms
    2-phospho-D-glycerate hydrolase, alpha-enolase, c-Myc promoter binding protein, Eno-1, MBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95393
    NCBI Gene: 13806
  • Gene Overview
    MyGene.info: ENO1
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:150236726-150248873 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 81.24 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95393
protein coding gene Chr4:150236721-150248879 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029153
protein coding gene Chr4:154187546-154201440 (+)
A/J MGP_AJ_G0029118
protein coding gene Chr4:147720595-147733337 (+)
AKR/J MGP_AKRJ_G0029066
protein coding gene Chr4:151776648-151789197 (+)
BALB/cJ MGP_BALBcJ_G0029134
protein coding gene Chr4:148219109-148231392 (+)
C3H/HeJ MGP_C3HHeJ_G0028855
protein coding gene Chr4:152317640-152330219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029583
protein coding gene Chr4:159732583-159748326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026829
protein coding gene Chr4:140129922-140142194 (+)
CAST/EiJ MGP_CASTEiJ_G0028268
protein coding gene Chr4:149582219-149597493 (+)
CBA/J MGP_CBAJ_G0028817
protein coding gene Chr4:164439922-164470290 (+)
DBA/2J MGP_DBA2J_G0028966
protein coding gene Chr4:147811016-147822932 (+)
FVB/NJ MGP_FVBNJ_G0028930
protein coding gene Chr4:146941907-146955903 (+)
LP/J MGP_LPJ_G0029056
protein coding gene Chr4:154109655-154130557 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028957
protein coding gene Chr4:167587980-167599978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029615
protein coding gene Chr4:152281893-152295389 (+)
PWK/PhJ MGP_PWKPhJ_G0027988
protein coding gene Chr4:143837021-143850189 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027822
protein coding gene Chr4:146542799-146554869 (+)
WSB/EiJ MGP_WSBEiJ_G0028348
protein coding gene Chr4:152419942-152436682 (+)



Homology
more
  • Human Ortholog
    ENO1, enolase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ENO1, enolase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ENO1L1, HEL-S-17, MPB1, NNE, PPH
  • Links
    NCBI Gene ID: 2023
    neXtProt AC: NX_P06733
    UniProt: P06733

  • Chr Location
    1p36.23; chr1:8861000-8879092 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 134343
    1 human;2 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ENO1
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous animals exhibit growth arrest and embryonic lethality at approximately E6.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13806 NCBI Gene Model | MGI Sequence Detail 12148 C57BL/6J ±  kb
    transcript NM_023119 RefSeq | MGI Sequence Detail 1831 C57BL/6  
    polypeptide P17182 UniProt | EBI | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 33
      Primer pair 1
      Other 2

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-9503, MGD-MRK-9506, MGI:2143710
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 20
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:5856 D'Ancona GG, et al., Assignment of the gene for enolase to mouse chromosome 4 using somatic cell hybrids. Cytogenet Cell Genet. 1977;19(1):1-6
    • Latest
      J:260356 Aiello FB, et al., IL-7-induced phosphorylation of the adaptor Crk-like and other targets. Cell Signal. 2018 Jul;47:131-141

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory