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En1
Gene Detail
 Symbol
Name
ID
En1
engrailed 1
MGI:95389
STS D1Mit217
Synonyms En-1, engrailed-1, Mo-en.1
Feature Type protein coding gene
Genetic Map
Chromosome 1
52.74 cM, cytoband C2-qter
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr1:120602418-120609296 bp, + strand
From VEGA annotation of GRCm38

  6879 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:50663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 zebrafish

Protein SuperFamily: homeobox protein, EN-1/EN-2 type
Gene Tree: En1

Human
homologs
Human Homolog EN1, engrailed homeobox 1
NCBI Gene ID 2019
neXtProt AC  NX_Q05925
Human Chr (Location)  2q14.2; chr2:118842171-118848183 (-)  GRCh38
Alleles
and
phenotypes
All alleles(16) : Targeted(16)
Incidental mutations (data from APF )
 
Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process dorsal/ventral pattern formation, embryonic forelimb morphogenesis, ...
Component membrane, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (268 records)
Data Summary: Results (792)    Tissues (333)    Images (206)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 62
RNA in situ 566
In situ reporter (knock in) 67
Northern blot 42
RT-PCR 55
cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(57) Genomic(6) cDNA(29) Primer pair(5) Other(17)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037271 (Evidence)
Ensembl Gene ModelENSMUSG00000058665 (Evidence)
Entrez Gene13798 (Evidence)
UniGene2657
DFCITC1589119
DoTSDT.40167192
NIA Mouse Gene IndexU000729
Consensus CDS ProjectCCDS15235.1
International Mouse Knockout Project StatusEn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037271 VEGA Gene Model | MGI Sequence Detail 6879 C57BL/6J ±  kb
transcript OTTMUST00000096137 VEGA | MGI Sequence Detail 3928 Not Applicable 
polypeptide OTTMUSP00000053676 VEGA | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms RFLP(8) : SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR019549 Homeobox engrailed, C-terminal
InterPro IPR019737 Homeobox engrailed-type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR000747 Homeodomain engrailed
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007070 homeobox protein engrailed-1
References (Earliest) J:8126 Joyner AL, et al., Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell. 1985 Nov;43(1):29-37
(Latest) J:208841 Millen KJ, et al., Transformation of the cerebellum into more ventral brainstem fates causes cerebellar agenesis in the absence of Ptf1a function. Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1777-86
All references(414)
Other
accession IDs
MGD-MRK-12340, MGD-MRK-9497, MGD-MRK-9499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory