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En1
Gene Detail
Symbol

Name
ID
En1
engrailed 1
MGI:95389
STS
Synonyms
En-1, engrailed-1, Mo-en.1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.74 cM, cytoband C2-qter
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr1:120602418-120607992 bp, + strand
From VEGA annotation of GRCm38

  5575 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:50663  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 zebrafish

HCOP human homology predictions: EN1
Protein SuperFamily: homeobox protein, EN-1/EN-2 type
Gene Tree: En1

Human
homologs
EN1, engrailed homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2019
neXtProt AC: NX_Q05925

Human Chr (Location): 2q14.2; chr2:118842171-118848183 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Incidental mutations (data from APF , CvDC )
 
Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described.
 
Mutations Annotated to Human Diseases (2)   
Interactions
En1 interacts with 279 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process dorsal/ventral pattern formation, embryonic forelimb morphogenesis, ...
Component membrane, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (274 records)
Data Summary: Results (805)    Tissues (339)    Images (212)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 63
RNA in situ 578
In situ reporter (knock in) 67
Northern blot 42
RT-PCR 55
cDNA source data(27)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100493090 ; ZFIN eng1a, eng1b    NEW 
Molecular
reagents
All nucleic(58) Genomic(6) cDNA(29) Primer pair(5) Other(18)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037271 (Evidence)
Ensembl Gene Model ENSMUSG00000058665 (Evidence)
Entrez Gene 13798 (Evidence)
UniGene 2657
DFCI TC1589119
DoTS DT.40167192
NIA Mouse Gene Index U000729
Consensus CDS Project CCDS15235.1
International Mouse Phenotyping Consortium Status En1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037271 VEGA Gene Model | MGI Sequence Detail 5575 C57BL/6J ±  kb
transcript OTTMUST00000096137 VEGA | MGI Sequence Detail 2624 Not Applicable 
polypeptide OTTMUSP00000053676 VEGA | MGI Sequence Detail 401 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(8) : SNPs within 2kb(40 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR019549 Homeobox engrailed, C-terminal
InterPro IPR019737 Homeobox engrailed-type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR000747 Homeodomain engrailed
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007070 homeobox protein engrailed-1
References
(Earliest) J:8126 Joyner AL, et al., Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell. 1985 Nov;43(1):29-37
(Latest) J:221427 Legue E, et al., Clonal analysis reveals granule cell behaviors and compartmentalization that determine the folded morphology of the cerebellum. Development. 2015 May 1;142(9):1661-71
All references(423)
Other
accession IDs
MGD-MRK-12340, MGD-MRK-9497, MGD-MRK-9499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory