Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described.
|InterPro||IPR017970||Homeobox, conserved site|
|InterPro||IPR019549||Homeobox engrailed, C-terminal|
|InterPro||IPR019737||Homeobox engrailed-type, conserved site|
|Protein Ontology||PR:000007070||homeobox protein engrailed-1|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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