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En1 Gene Detail
Summary
  • Symbol
    En1
  • Name
    engrailed 1
  • Synonyms
    En-1, engrailed-1, Mo-en.1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95389
    NCBI Gene: 13798
  • Gene Overview
    MyGene.info: EN1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:120602487-120607991 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.74 cM, cytoband C2-qter
  • Mapping Data
    25 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95389
protein coding gene Chr1:120602418-120607992 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016408
protein coding gene Chr1:123415075-123420646 (+)
A/J MGP_AJ_G0016391
protein coding gene Chr1:118988501-118994062 (+)
AKR/J MGP_AKRJ_G0016356
protein coding gene Chr1:122492493-122498072 (+)
BALB/cJ MGP_BALBcJ_G0016351
protein coding gene Chr1:119248125-119253695 (+)
C3H/HeJ MGP_C3HHeJ_G0016177
protein coding gene Chr1:122659614-122665187 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016812
protein coding gene Chr1:128090098-128095657 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014525
protein coding gene Chr1:112626403-112632011 (+)
CAST/EiJ MGP_CASTEiJ_G0015758
protein coding gene Chr1:121467750-121473291 (+)
CBA/J MGP_CBAJ_G0016150
protein coding gene Chr1:132564968-132570549 (+)
DBA/2J MGP_DBA2J_G0016256
protein coding gene Chr1:118004202-118009767 (+)
FVB/NJ MGP_FVBNJ_G0016255
protein coding gene Chr1:116770206-116775777 (+)
LP/J MGP_LPJ_G0016327
protein coding gene Chr1:124763981-124770535 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016280
protein coding gene Chr1:138270239-138276847 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016848
protein coding gene Chr1:122202748-122208337 (+)
PWK/PhJ MGP_PWKPhJ_G0015544
protein coding gene Chr1:117002907-117008549 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015332
protein coding gene Chr1:121113675-121119238 (+)
WSB/EiJ MGP_WSBEiJ_G0015820
protein coding gene Chr1:122089338-122094917 (+)



Homology
more
  • Human Ortholog
    EN1, engrailed homeobox 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    EN1, engrailed homeobox 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2019
    neXtProt AC: NX_Q05925
    UniProt: Q05925

  • Chr Location
    2q14.2; chr2:118842171-118848183 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    107 phenotypes from 17 alleles in 16 genetic backgrounds
    138 phenotypes from multigenic genotypes
    1 images
    203 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant homozygotes usually die within 24 hours of birth. Mutants exhibit nervous system defects, including a lack of most of the colliculi, cerebellum, and the third and fourth cranial nerves in some lines. Skeletal anomalies have also been described.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13798 NCBI Gene Model | MGI Sequence Detail 5505 C57BL/6J ±  kb
    transcript NM_010133 RefSeq | MGI Sequence Detail 2554 C57BL/6  
    polypeptide P09065 UniProt | EBI | MGI Sequence Detail 401 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 6
      cDNA 31
      Primer pair 6
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12340, MGD-MRK-9497, MGD-MRK-9499
    References
    more
    • Summaries
      All 516
      Developmental Gene Expression 304
      Diseases 3
      Gene Ontology 18
      Phenotypes 203
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:273024 DiNuoscio G, et al., Wnt/beta-catenin signaling in the mouse embryonic cranial mesenchyme is required to sustain the emerging differentiated meningeal layers. Genesis. 2019 Jan;57(1):e23279

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    12/03/2019
    MGI 6.14
    The Jackson Laboratory