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Emx2
Gene Detail
Symbol

Name
ID
Emx2
empty spiracles homeobox 2
MGI:95388
Synonyms
Pdo
Feature Type
protein coding gene
Genetic Map
Chromosome 19
56.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr19:59458372-59465357 bp, + strand
From VEGA annotation of GRCm38

  6986 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3023  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EMX2
Gene Tree: Emx2

Human
homologs
EMX2, empty spiracles homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2018
neXtProt AC: NX_Q04743

Human Chr (Location): 10q26.1; chr10:117542445-117549546 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EMX2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene causes neonatal death, impaired urogenital development and malformation of several forebrain regions. Heterozygotes for a null allele show middle and inner ear defects. Homozygotes for an ENU-induced allele die neonatally with middle ear defects and small kidneys.
 
Interactions
Emx2 interacts with 230 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process anterior/posterior pattern specification, brain development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (175 records)
Data Summary: Results (688)    Tissues (337)    Images (134)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 611
Northern blot 4
RT-PCR 59
cDNA source data(15)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EMX2 ; Xenbase emx2 ; ZFIN emx2    NEW 
Molecular
reagents
All nucleic(39) Genomic(1) cDNA(17) Primer pair(7) Other(14)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000037270 (Evidence)
Ensembl Gene Model ENSMUSG00000043969 (Evidence)
Entrez Gene 13797 (Evidence)
UniGene 245394
DFCI TC1584850
NIA Mouse Gene Index U043743
Consensus CDS Project CCDS29937.1
International Mouse Phenotyping Consortium Status Emx2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037270 VEGA Gene Model | MGI Sequence Detail 6986 C57BL/6J ±  kb
transcript OTTMUST00000096129 VEGA | MGI Sequence Detail 2916 Not Applicable 
polypeptide OTTMUSP00000053670 VEGA | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000007069 homeobox protein EMX2
References
(Earliest) J:1461 Simeone A, et al., Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 1992 Jul;11(7):2541-50
(Latest) J:218288 Falcone C, et al., Emx2 expression levels in NSCs modulate astrogenesis rates by regulating EgfR and Fgf9. Glia. 2015 Mar;63(3):412-22
All references(241)
Other
accession IDs
MGD-MRK-9496, MGI:1890590

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory