Emx2
Gene Detail

Symbol Name ID

Emx2 empty spiracles homeobox 2 MGI:95388

Synonyms

Pdo

Feature Type

protein coding gene

Genetic Map

Chromosome 19

56.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr19:59458690-59465357 bp, + strand From VEGA annotation of GRCm38   6668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3023  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Emx2

Human homologs

Human Homolog		EMX2, empty spiracles homeobox 2
NCBI Gene ID		2018
neXtProt AC		NX_Q04743
Human Chr (Location)		10q26.1; chr10:119301956-119309057 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EMX2

Alleles and phenotypes

All alleles(8) : Targeted(6) Chemically induced(2)
 

Homozygous disruption of this gene causes neonatal death, impaired urogenital development and malformation of several forebrain regions. Heterozygotes for a null allele show middle and inner ear defects. Homozygotes for an ENU-induced allele die neonatally with middle ear defects and small kidneys.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	anterior/posterior pattern specification, brain development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (161 records)
Data Summary: Results (666)    Tissues (312)    Images (124)
Theiler Stages: 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	601
Northern blot	4
RT-PCR	59

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(37) Genomic(1) cDNA(17) Primer pair(7) Other(12)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000037270 (Evidence)
Ensembl Gene Model	ENSMUSG00000043969 (Evidence)
Entrez Gene	13797 (Evidence)
UniGene	245394
DFCI	TC1584850
NIA Mouse Gene Index	U043743
Consensus CDS Project	CCDS29937.1
International Mouse Knockout Project Status	Emx2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000037270	VEGA Gene Model | MGI Sequence Detail	6668	C57BL/6J
transcript	OTTMUST00000096129	VEGA | MGI Sequence Detail	2598	Not Applicable
polypeptide	OTTMUSP00000053670	VEGA | MGI Sequence Detail	253	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(23 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000007069	homeobox protein EMX2

References

(Earliest) J:1461 Simeone A, et al., Two vertebrate homeobox genes related to the Drosophila empty spiracles gene are expressed in the embryonic cerebral cortex. EMBO J. 1992 Jul;11(7):2541-50
(Latest) J:191095 Gierl MS, et al., GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012 Nov 13;23(5):1032-42
All references(223)

Other accession IDs

MGD-MRK-9496, MGI:1890590