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Cela2a Gene Detail
Summary
  • Symbol
    Cela2a
  • Name
    chymotrypsin-like elastase family, member 2A
  • Synonyms
    Ela2, Ela-2, Ela2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:95316
    NCBI Gene: 13706
  • Gene Overview
    MyGene.info: CELA2A
Location & Maps
more
  • Sequence Map
    Chr4:141814962-141826160 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      11199 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.75 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CELA2A, chymotrypsin like elastase family member 2A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CELA2A, chymotrypsin like elastase family member 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ELA2A, PE-1
  • Links
    NCBI Gene ID: 63036
    neXtProt AC: NX_P08217

  • Chr Location
    1p36.21; chr1:15456728-15472091 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    3 involving Cela2a
  • Incidental Mutations
    Mutagenetix , APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    31
  • Tissues
    21
  • cDNA Data
    7
  • Literature Summary
    7
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009988 VEGA Gene Model | MGI Sequence Detail 11199 C57BL/6J ±  kb
transcript OTTMUST00000023221 VEGA | MGI Sequence Detail 1070 Not Applicable  
polypeptide OTTMUSP00000010607 VEGA | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    496 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007010 chymotrypsin-like elastase family member 2A
  • EC
    3.4.21.71
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 10
    Genomic 3
    cDNA 7

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9352, MGD-MRK-9355
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
  • Latest
    J:221734 Liu S, et al., Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development. Am J Physiol Lung Cell Mol Physiol. 2014 Jun 15;306(12):L1104-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory