Cela2a
Gene Detail

Symbol

Name
ID

Cela2a
chymotrypsin-like elastase family, member 2A
MGI:95316

Synonyms

Ela2, Ela-2, Ela2a

Feature Type

protein coding gene

Genetic Map

Chromosome 4
74.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr4:141814962-141826160 bp, - strand From VEGA annotation of GRCm38   11199 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:40598  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 western clawed frog; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Cela2a

Human
homologs

Human Homolog		CELA2A, chymotrypsin-like elastase family, member 2A
NCBI Gene ID		63036
neXtProt AC		NX_P08217
Human Synonyms		ELA2A, PE-1
Human Chr (Location)		1p36.21; chr1:15456728-15472091 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(2) : Targeted(2)
Genomic Mutations involving Cela2a (1)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Cela2a interacts with 3 markers (Mir138-2, Mir183, Mir1968)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Process	establishment of skin barrier, proteolysis
Component	extracellular region, keratohyalin granule
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (8)    Tissues (3)    Tissue x Stage Matrix (view)

Assay Type	Results
Northern blot	8

cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(7) Genomic(3) cDNA(4)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000009988 (Evidence)
Ensembl Gene Model	ENSMUSG00000058579 (Evidence)
Entrez Gene	13706 (Evidence)
DFCI	TC1573399
DoTS	DT.91438088
EC	3.4.21.71
Consensus CDS Project	CCDS18884.1
International Mouse Knockout Project Status	Cela2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009988	VEGA Gene Model | MGI Sequence Detail	11199	C57BL/6J
transcript	OTTMUST00000023221	VEGA | MGI Sequence Detail	1070	Not Applicable
polypeptide	OTTMUSP00000010607	VEGA | MGI Sequence Detail	271	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(522 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000007010	chymotrypsin-like elastase family member 2A

References

(Earliest) J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
(Latest) J:214089 Hale MA, et al., The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Development. 2014 Aug;141(16):3123-33
All references(32)

Other
accession IDs

MGD-MRK-9352, MGD-MRK-9355