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Cela2a
Gene Detail
Symbol

Name
ID
Cela2a
chymotrypsin-like elastase family, member 2A
MGI:95316
Synonyms
Ela2, Ela-2, Ela2a
Feature Type
protein coding gene
Genetic Map
Chromosome 4
74.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:141814962-141826160 bp, - strand
From VEGA annotation of GRCm38

  11199 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40598  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 2 western clawed frog; 2 zebrafish

Protein SuperFamily: trypsin
Gene Tree: Cela2a

Human
homologs
Human Homolog CELA2A, chymotrypsin-like elastase family, member 2A
NCBI Gene ID 63036
neXtProt AC  NX_P08217
Human Synonyms  ELA2A, PE-1
Human Chr (Location)  1p36.21; chr1:15456728-15472091 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cela2a interacts with 3 markers (Mir138-2, Mir183, Mir1968)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process establishment of skin barrier, proteolysis
Component extracellular region, keratohyalin granule
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (8)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 8
cDNA source data(4)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) Genomic(3) cDNA(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000009988 (Evidence)
Ensembl Gene ModelENSMUSG00000058579 (Evidence)
Entrez Gene13706 (Evidence)
DFCITC1573399
DoTSDT.91438088
EC3.4.21.71
Consensus CDS ProjectCCDS18884.1
International Mouse Knockout Project StatusCela2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009988 VEGA Gene Model | MGI Sequence Detail 11199 C57BL/6J ±  kb
transcript OTTMUST00000023221 VEGA | MGI Sequence Detail 1070 Not Applicable 
polypeptide OTTMUSP00000010607 VEGA | MGI Sequence Detail 271 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(522 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007010 chymotrypsin-like elastase family member 2A
References
(Earliest) J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)
Other
accession IDs
MGD-MRK-9352, MGD-MRK-9355

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory