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Cela2a Gene Detail
Summary
  • Symbol
    Cela2a
  • Name
    chymotrypsin-like elastase family, member 2A
  • Synonyms
    Ela2, Ela-2, Ela2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:95316
    NCBI Gene: 13706
  • Gene Overview
    MyGene.info: CELA2A
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141814954-141826005 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95316
 protein coding gene Chr4:141814954-141826160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029059
 protein coding gene Chr4:144919307-144930509 (-)
A/J MGP_AJ_G0029019
 protein coding gene Chr4:138598891-138610089 (-)
AKR/J MGP_AKRJ_G0028971
 protein coding gene Chr4:142631641-142642109 (-)
BALB/cJ MGP_BALBcJ_G0029043
 protein coding gene Chr4:139289608-139300039 (-)
C3H/HeJ MGP_C3HHeJ_G0028757
 protein coding gene Chr4:142987665-142999019 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029484
 protein coding gene Chr4:149957106-149968290 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0028189
 protein coding gene Chr4:141245425-141256896 (-)
CBA/J MGP_CBAJ_G0028721
 protein coding gene Chr4:154384210-154397664 (-)
DBA/2J MGP_DBA2J_G0028871
 protein coding gene Chr4:138985638-138997043 (-)
FVB/NJ MGP_FVBNJ_G0028838
 protein coding gene Chr4:138106612-138117783 (-)
LP/J MGP_LPJ_G0028970
 protein coding gene Chr4:144923136-144934338 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028864
 protein coding gene Chr4:158105341-158116514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029522
 protein coding gene Chr4:143152472-143163843 (-)
PWK/PhJ MGP_PWKPhJ_G0027910
 protein coding gene Chr4:135884337-135895784 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027734
 protein coding gene Chr4:138944670-138956237 (-)
WSB/EiJ MGP_WSBEiJ_G0028267
 protein coding gene Chr4:143408562-143419965 (-)



Homology
more
  • Human Ortholog
    CELA2A, chymotrypsin like elastase 2A
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CELA2A, chymotrypsin like elastase 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOMS4, ELA2A, PE-1
  • Links
    NCBI Gene ID: 63036
    neXtProt AC: NX_P08217
    UniProt: P08217

  • Chr Location
    1p36.21; chr1:15456728-15472091 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered cardiac sympathovagal balance, reduced heart rate, and decreased cardiac output, stroke volume and heart ventricular size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    31
  • Tissues
    21
  • cDNA Data
    8
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13706 NCBI Gene Model | MGI Sequence Detail 11052 C57BL/6J ±  kb
    transcript NM_007919 RefSeq | MGI Sequence Detail 923 C57BL/6  
    polypeptide P05208 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 3
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9352, MGD-MRK-9355
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:8507 Stevenson BJ, et al., Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes. Nucleic Acids Res. 1986 Nov 11;14(21):8307-30
    • Latest
      J:275582 Becari C, et al., Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice. Front Physiol. 2017;8:170
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/14/2020
    MGI 6.14     		The Jackson Laboratory