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Cela1
Gene Detail
Symbol

Name
ID
Cela1
chymotrypsin-like elastase family, member 1
MGI:95314
Synonyms
1810009A17Rik, 1810062B19Rik, Ela1, Ela-1, PC-TsF
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.38 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:100674425-100687920 bp, - strand
From Ensembl annotation of GRCm38

  13496 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 6 western clawed frog

HCOP human homology predictions: CELA1
Protein SuperFamily: trypsin
Gene Tree: Cela1

Human
homologs
CELA1, chymotrypsin-like elastase family, member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1990
neXtProt AC: NX_Q9UNI1

Human Synonyms: ELA1

Human Chr (Location): 12q13; chr12:51328443-51346679 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Radiation induced(1) Targeted(2)
Genomic Mutations involving Cela1 (1)
Incidental mutations (data from CvDC )
Phenotype Images(2)
Interactions
Cela1 interacts with 33 markers (Mir16-1, Mir25, Mir105, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process digestive system development, exocrine pancreas development, ...
Component extracellular region
Function hydrolase activity, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (20)    Tissues (3)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
Northern blot 8
RT-PCR 2
cDNA source data(274)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cela1    NEW 
Molecular
reagents
All nucleic(277) cDNA(276) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000023031 (Evidence)
Entrez Gene 109901 (Evidence)
UniGene 2131
DFCI TC1572034, TC1592557
DoTS DT.55134284, DT.55152894
NIA Mouse Gene Index U041188
EC 3.4.21.36
Consensus CDS Project CCDS37213.1
International Mouse Phenotyping Consortium Status Cela1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023031 Ensembl Gene Model | MGI Sequence Detail 13496 C57BL/6J ±  kb
transcript ENSMUST00000023775 Ensembl | MGI Sequence Detail 1103 Not Applicable 
polypeptide ENSMUSP00000023775 Ensembl | MGI Sequence Detail 266 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000007008 chymotrypsin-like elastase family member 1
References
(Earliest) J:7529 Honey NK, et al., Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul;10(4):377-83
(Latest) J:218695 Soggia A, et al., von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-alpha and VEGF-A upregulation. Diabetologia. 2014 Nov;57(11):2348-56
All references(41)
Other
accession IDs
MGD-MRK-9350, MGD-MRK-9353, MGI:1917096, MGI:1923996

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory