Cela1
Gene Detail

Symbol

Name
ID

Cela1
chymotrypsin-like elastase family, member 1
MGI:95314

Synonyms

1810009A17Rik, 1810062B19Rik, Ela1, Ela-1, PC-TsF

Feature Type

protein coding gene

Genetic Map

Chromosome 15
56.38 cM, cytoband F1-F3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:100674425-100687920 bp, - strand From Ensembl annotation of GRCm38   13496 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20454  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 6 western clawed frog

Protein SuperFamily: trypsin
Gene Tree: Cela1

Human
homologs

Human Homolog		CELA1, chymotrypsin-like elastase family, member 1
NCBI Gene ID		1990
neXtProt AC		NX_Q9UNI1
Human Synonyms		ELA1
Human Chr (Location)		12q13; chr12:51328443-51346679 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(8) : Gene trapped(5) Radiation induced(1) Targeted(2)
Genomic Mutations involving Cela1 (1)
Phenotype Images(2)

Interactions

Cela1 interacts with 33 markers (Mir16-1, Mir25, Mir105, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	digestive system development, exocrine pancreas development, ...
Component	extracellular region
Function	hydrolase activity, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (20)    Tissues (3)    Images (10)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	10
Northern blot	8
RT-PCR	2

cDNA source data(274)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(277) cDNA(276) Primer pair(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000023031 (Evidence)
Entrez Gene	109901 (Evidence)
UniGene	2131
DFCI	TC1572034, TC1592557
DoTS	DT.55134284, DT.55152894
NIA Mouse Gene Index	U041188
EC	3.4.21.36
Consensus CDS Project	CCDS37213.1
International Mouse Knockout Project Status	Cela1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023031	Ensembl Gene Model | MGI Sequence Detail	13496	C57BL/6J
transcript	ENSMUST00000023775	Ensembl | MGI Sequence Detail	1103	Not Applicable
polypeptide	ENSMUSP00000023775	Ensembl | MGI Sequence Detail	266	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(167 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000007008	chymotrypsin-like elastase family member 1

References

(Earliest) J:4779 Honey NK, et al., Assignment in mouse of the genes for chymotrypsinogen B, elastase, trypsin, and carboxypeptidase A (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):492-493 (Abstr.) (399-616)
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(47)

Other
accession IDs

MGD-MRK-9350, MGD-MRK-9353, MGI:1917096, MGI:1923996