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Cela1 Gene Detail
Summary
  • Symbol
    Cela1
  • Name
    chymotrypsin-like elastase family, member 1
  • Synonyms
    1810009A17Rik, 1810062B19Rik, Ela1, Ela-1, PC-TsF
  • Feature Type
    protein coding gene
  • IDs
    MGI:95314
    NCBI Gene: 109901
  • Gene Overview
    MyGene.info: CELA1
Location & Maps
more
  • Sequence Map
    Chr15:100674425-100687920 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      13496 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.38 cM, cytoband F1-F3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    CELA1, chymotrypsin like elastase family member 1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    CELA1, chymotrypsin like elastase family member 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ELA1
  • Links
    NCBI Gene ID: 1990
    neXtProt AC: NX_Q9UNI1

  • Chr Location
    12q13; chr12:51328443-51346679 (-)  GRCh38.p2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Cela1
  • Incidental Mutations
    CvDC
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    20
  • Tissues
    3
  • cDNA Data
    274
  • Literature Summary
    12
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023031 Ensembl Gene Model | MGI Sequence Detail 13496 C57BL/6J ±  kb
transcript ENSMUST00000023775 Ensembl | MGI Sequence Detail 1103 Not Applicable  
polypeptide ENSMUSP00000023775 Ensembl | MGI Sequence Detail 266 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    158 from dbSNP Build 142
  • RFLP
    1
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007008 chymotrypsin-like elastase family member 1
  • EC
    3.4.21.36
  • InterPro Domains
    IPR001314 Peptidase S1A, chymotrypsin family
    IPR009003 Peptidase S1, PA clan
    IPR001254 Serine proteases, trypsin domain
    IPR018114 Serine proteases, trypsin family, histidine active site
    IPR033116 Serine proteases, trypsin family, serine active site
Molecular
Reagents
less
  • All nucleic 277
    cDNA 276
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9350, MGD-MRK-9353, MGI:1917096, MGI:1923996
References
more
  • Summaries
    All 41
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:7529 Honey NK, et al., Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul;10(4):377-83
  • Latest
    J:230849 Joshi R, et al., Stretch regulates expression and binding of chymotrypsin-like elastase 1 in the postnatal lung. FASEB J. 2016 Feb;30(2):590-600
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory