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Cela1 Gene Detail
Summary
  • Symbol
    Cela1
  • Name
    chymotrypsin-like elastase family, member 1
  • Synonyms
    1810009A17Rik, 1810062B19Rik, Ela1, Ela-1, PC-TsF
  • Feature Type
    protein coding gene
  • IDs
    MGI:95314
    NCBI Gene: 109901
  • Gene Overview
    MyGene.info: CELA1
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:100674422-100687920 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.38 cM, cytoband F1-F3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95314
 protein coding gene Chr15:100674421-100687921 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022359
 protein coding gene Chr15:102658796-102674329 (-)
A/J MGP_AJ_G0022321
 protein coding gene Chr15:98614458-98628469 (-)
AKR/J MGP_AKRJ_G0022297
 protein coding gene Chr15:101625853-101642883 (-)
BALB/cJ MGP_BALBcJ_G0022325
 protein coding gene Chr15:98725093-98739409 (-)
C3H/HeJ MGP_C3HHeJ_G0022095
 protein coding gene Chr15:101707011-101728118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022773
 protein coding gene Chr15:106515077-106530422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020298
 protein coding gene Chr15:94364174-94376961 (-)
CAST/EiJ MGP_CASTEiJ_G0021620
 protein coding gene Chr15:102557251-102570764 (-)
CBA/J MGP_CBAJ_G0022064
 protein coding gene Chr15:110159506-110181819 (-)
DBA/2J MGP_DBA2J_G0022191
 protein coding gene Chr15:97965946-97979510 (-)
FVB/NJ MGP_FVBNJ_G0022170
 protein coding gene Chr15:96987867-97004855 (-)
LP/J MGP_LPJ_G0022262
 protein coding gene Chr15:102812836-102828753 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022191
 protein coding gene Chr15:113887693-113904185 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022787
 protein coding gene Chr15:101625813-101646464 (-)
PWK/PhJ MGP_PWKPhJ_G0021359
 protein coding gene Chr15:98098458-98113556 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021191
 protein coding gene Chr15:101520302-101536995 (-)
WSB/EiJ MGP_WSBEiJ_G0021670
 protein coding gene Chr15:102254320-102270812 (-)



Homology
more
  • Human Ortholog
    CELA1, chymotrypsin like elastase 1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    CELA1, chymotrypsin like elastase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ELA1
  • Links
    NCBI Gene ID: 1990
    neXtProt AC: NX_Q9UNI1
    UniProt: Q9UNI1

  • Chr Location
    12q13.13; chr12:51328443-51346679 (-)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced elastase activity in distal airspace walls, increased elastin fibers in airspace walls, increased wet-to-dry lung weight ratio, and increased lung elastance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    20
  • Tissues
    3
  • cDNA Data
    275
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109901 NCBI Gene Model | MGI Sequence Detail 13499 C57BL/6J ±  kb
    transcript NM_033612 RefSeq | MGI Sequence Detail 1124 C57BL/6  
    polypeptide Q91X79 UniProt | EBI | MGI Sequence Detail 266 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 278
      cDNA 277
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9350, MGD-MRK-9353, MGI:1917096, MGI:1923996
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 5
      Phenotypes 25
    • Earliest
      J:7529 Honey NK, et al., Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse. Somat Cell Mol Genet. 1984 Jul;10(4):377-83
    • Latest
      J:278574 Joshi R, et al., Role for Cela1 in Postnatal Lung Remodeling and Alpha-1 Antitrypsin-Deficient Emphysema. Am J Respir Cell Mol Biol. 2018 Aug;59(2):167-178
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/15/2019
    MGI 6.14     		The Jackson Laboratory