About   Help   FAQ
Eif4e
Gene Detail
 Symbol
Name
ID
Eif4e
eukaryotic translation initiation factor 4E
MGI:95305
Synonyms eIF-4E, If4e
Feature Type protein coding gene
Genetic Map
Chromosome 3
64.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:138526191-138557599 bp, + strand
From NCBI annotation of GRCm38

  31409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Eif4e

Human
homologs
Human Homolog EIF4E, eukaryotic translation initiation factor 4E
NCBI Gene ID 1977
neXtProt AC  NX_P06730
Human Synonyms  AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F
Human Chr (Location)  4q21-q25; chr4:98878456-98930635 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF4E
Mutations,
alleles, and
phenotypes
All mutations/alleles(64) : Gene trapped(60) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-in allele exhibit resistance to developing prostate intraepithelial neoplasia.
 
Interactions
Eif4e interacts with 320 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process G1/S transition of mitotic cell cycle, positive regulation of mitotic cell cycle, ...
Component chromatoid body, cytoplasm, ...
Function eukaryotic initiation factor 4G binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (11)    Tissues (7)   
Theiler Stages: 1, 2, 3, 4, 21, 28
Assay TypeResults
Western blot 4
RT-PCR 7
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000028156 (Evidence)
Entrez Gene13684 (Evidence)
DFCITC1573339, TC1669998
DoTSDT.101137570, DT.536802, DT.94359429, DT.97342900
PDB1EJH, 1L8B, 1EJ1, 1EJ4
Consensus CDS ProjectCCDS38654.1
International Mouse Knockout Project StatusEif4e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13684 NCBI Gene Model | MGI Sequence Detail 31409 C57BL/6J ±  kb
transcript NM_007917 RefSeq | MGI Sequence Detail 2882 C57BL/6 
polypeptide P63073 UniProt | EBI | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(7) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
InterPro IPR001040 Translation Initiation factor eIF- 4e
InterPro IPR023398 Translation Initiation factor eIF- 4e-like domain
Protein Ontology PR:000006990 eukaryotic translation initiation factor 4E
Graphical View of Protein Domain Structure
References (Earliest) J:9886 Altmann M, et al., A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J Biol Chem. 1989 Jul 25;264(21):12145-7
(Latest) J:194400 Santini E, et al., Exaggerated translation causes synaptic and behavioural aberrations associated with autism. Nature. 2013 Jan 17;493(7432):411-5
All references(66)
Other
accession IDs
MGD-MRK-11199, MGD-MRK-9339, MGI:3649046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory