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Eif4e Gene Detail
Summary
  • Symbol
    Eif4e
  • Name
    eukaryotic translation initiation factor 4E
  • Synonyms
    eIF-4E, If4e
  • Feature Type
    protein coding gene
  • IDs
    MGI:95305
    NCBI Gene: 13684
  • Gene Overview
    MyGene.info: EIF4E
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138526191-138559696 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.30 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95305
protein coding gene Chr3:138526179-138559696 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027933
protein coding gene Chr3:141578015-141617536 (+)
A/J MGP_AJ_G0027890
protein coding gene Chr3:136566600-136601520 (+)
AKR/J MGP_AKRJ_G0027856
protein coding gene Chr3:140195382-140228848 (+)
BALB/cJ MGP_BALBcJ_G0027902
protein coding gene Chr3:136377458-136412031 (+)
C3H/HeJ MGP_C3HHeJ_G0027632
protein coding gene Chr3:140535774-140569922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028346
protein coding gene Chr3:146471080-146505600 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025684
protein coding gene Chr3:131991679-132017676 (+)
CAST/EiJ MGP_CASTEiJ_G0027088
protein coding gene Chr3:140314808-140351120 (+)
CBA/J MGP_CBAJ_G0027609
protein coding gene Chr3:151454422-151490421 (+)
DBA/2J MGP_DBA2J_G0027748
protein coding gene Chr3:135693624-135729887 (+)
FVB/NJ MGP_FVBNJ_G0027715
protein coding gene Chr3:133153208-133189450 (+)
LP/J MGP_LPJ_G0027858
protein coding gene Chr3:142982236-143022313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027747
protein coding gene Chr3:159553116-159586677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028404
protein coding gene Chr3:139748436-139782614 (+)
PWK/PhJ MGP_PWKPhJ_G0026812
protein coding gene Chr3:135464192-135492582 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026639
protein coding gene Chr3:137867791-137898823 (+)
WSB/EiJ MGP_WSBEiJ_G0027167
protein coding gene Chr3:140602712-140637519 (+)



Homology
more
  • Human Ortholog
    EIF4E, eukaryotic translation initiation factor 4E
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EIF4E, eukaryotic translation initiation factor 4E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AUTS19, CBP, eIF-4E, EIF4E1, EIF4EL1, EIF4F
  • Links
    NCBI Gene ID: 1977
    neXtProt AC: NX_P06730
    UniProt: P06730

  • Chr Location
    4q23; chr4:98878456-98930635 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 123817
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF4E
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Eif4e mouse models; 1 with human EIF4E associations

Human Disease Mouse Models
      
IDs
View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit resistance to developing prostate intraepithelial neoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13684 NCBI Gene Model | MGI Sequence Detail 33506 C57BL/6J ±  kb
    transcript NM_001313980 RefSeq | MGI Sequence Detail 5031 C57BL/6  
    polypeptide P63073 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11199, MGD-MRK-9339, MGI:3649046
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 12
      Diseases 3
      Gene Ontology 20
      Phenotypes 24
    • Earliest
      J:9886 Altmann M, et al., A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J Biol Chem. 1989 Jul 25;264(21):12145-7
    • Latest
      J:273291 Jeong SJ, et al., A threonyl-tRNA synthetase-mediated translation initiation machinery. Nat Commun. 2019 Mar 22;10(1):1357

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory