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Eif4e Gene Detail
Summary
  • Symbol
    Eif4e
  • Name
    eukaryotic translation initiation factor 4E
  • Synonyms
    eIF-4E, If4e
  • Feature Type
    protein coding gene
  • IDs
    MGI:95305
    NCBI Gene: 13684
  • Gene Overview
    MyGene.info: EIF4E
Location & Maps
more
  • Sequence Map
    Chr3:138526179-138559696 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33518 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 64.30 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    EIF4E, eukaryotic translation initiation factor 4E
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EIF4E, eukaryotic translation initiation factor 4E
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AUTS19, CBP, eIF-4E, EIF4E1, EIF4EL1, EIF4F
  • Links
    NCBI Gene ID: 1977
    neXtProt AC: NX_P06730

  • Chr Location
    4q23; chr4:98878456-98930635 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 123817
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EIF4E
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Eif4e mouse models; 1 with human EIF4E associations

Human Disease Mouse Models
       Autism   OMIM: 209850 View 2 models
       Autism, Susceptibility to, 19; AUTS19   OMIM: 615091
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 4 genetic backgrounds
    15 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    71
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Radiation induced
    1
  • Targeted
    5
  • Transgenic
    2
  • Genomic Mutations
    2 involving Eif4e
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-in allele exhibit resistance to developing prostate intraepithelial neoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052912 VEGA Gene Model | MGI Sequence Detail 33518 C57BL/6J ±  kb
transcript OTTMUST00000132422 VEGA | MGI Sequence Detail 4991 Not Applicable  
polypeptide OTTMUSP00000070604 VEGA | MGI Sequence Detail 217 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    92 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    Genomic 1
    cDNA 15
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11199, MGD-MRK-9339, MGI:3649046
References
more
  • Summaries
    All 73
    Developmental Gene Expression 10
    Diseases 2
    Gene Ontology 16
    Phenotypes 21
  • Earliest
    J:9886 Altmann M, et al., A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J Biol Chem. 1989 Jul 25;264(21):12145-7
  • Latest
    J:224214 Truitt ML, et al., Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2;162(1):59-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory