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Eif4e
Gene Detail
Symbol

Name
ID
Eif4e
eukaryotic translation initiation factor 4E
MGI:95305
Synonyms
eIF-4E, If4e
Feature Type
protein coding gene
Genetic Map
Chromosome 3
64.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:138526191-138557599 bp, + strand
From NCBI annotation of GRCm38

  31409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123817  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: EIF4E
Gene Tree: Eif4e

Human
homologs
EIF4E, eukaryotic translation initiation factor 4E
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1977
neXtProt AC: NX_P06730

Human Synonyms: AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F

Human Chr (Location): 4q23; chr4:98878456-98930635 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human EIF4E

Mutations,
alleles, and
phenotypes
All mutations/alleles(66) : Gene trapped(60) Targeted(5) Transgenic(1)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a knock-in allele exhibit resistance to developing prostate intraepithelial neoplasia.
 
Human Diseases Modeled in Mice Using Eif4e (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Eif4e interacts with 320 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process behavioral fear response, G1/S transition of mitotic cell cycle, ...
Component chromatoid body, cytoplasm, ...
Function enzyme binding, eukaryotic initiation factor 4G binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (11)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 4
RT-PCR 7
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eif4e ; ZFIN eif4ea, eif4eb    NEW 
Molecular
reagents
All nucleic(17) Genomic(1) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000028156 (Evidence)
Entrez Gene 13684 (Evidence)
DFCI TC1669998, TC1573339
DoTS DT.94359429, DT.536802, DT.101137570, DT.97342900
PDB 1L8B, 1EJH, 1EJ1, 1EJ4
Consensus CDS Project CCDS38654.1
International Mouse Phenotyping Consortium Status Eif4e
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13684 NCBI Gene Model | MGI Sequence Detail 31409 C57BL/6J ±  kb
transcript NM_007917 RefSeq | MGI Sequence Detail 2882 C57BL/6 
polypeptide P63073 UniProt | EBI | MGI Sequence Detail 217 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019770 Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
InterPro IPR001040 Translation Initiation factor eIF- 4e
InterPro IPR023398 Translation Initiation factor eIF- 4e-like domain
Protein Ontology PR:000006990 eukaryotic translation initiation factor 4E
Graphical View of Protein Domain Structure
References
(Earliest) J:9886 Altmann M, et al., A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J Biol Chem. 1989 Jul 25;264(21):12145-7
(Latest) J:217461 Yang G, et al., An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program. Neuron. 2014 Nov 19;84(4):723-39
All references(69)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-11199, MGD-MRK-9339, MGI:3649046

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory