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Eif4a1 Gene Detail
Summary
  • Symbol
    Eif4a1
  • Name
    eukaryotic translation initiation factor 4A1
  • Synonyms
    Eif4, initiation factor eIF-4A long form
  • Feature Type
    protein coding gene
  • IDs
    MGI:95303
    NCBI Gene: 13681
  • Gene Overview
    MyGene.info: EIF4A1
Location & Maps
more
  • Sequence Map
    Chr11:69666936-69672423 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5488 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EIF4A1, eukaryotic translation initiation factor 4A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EIF4A1, eukaryotic translation initiation factor 4A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DDX2A, EIF4A, EIF-4A, eIF-4A-I, eIF4A-I
  • Links
    NCBI Gene ID: 1973
    neXtProt AC: NX_P60842

  • Chr Location
    17p13; chr17:7572706-7579006 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotype references
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    10
  • Targeted
    4
  • Genomic Mutations
    2 involving Eif4a1
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005995 VEGA Gene Model | MGI Sequence Detail 5488 C57BL/6J ±  kb
transcript OTTMUST00000013412 VEGA | MGI Sequence Detail 1774 Not Applicable  
polypeptide OTTMUSP00000006211 VEGA | MGI Sequence Detail 406 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000006986 eukaryotic initiation factor 4A-I
  • EC
  • InterPro Domains
    IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
    IPR011545 DEAD/DEAH box helicase domain
    IPR031258 Eukaryotic initiation factor 4A-I/II
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR014014 RNA helicase, DEAD-box type, Q motif
Molecular
Reagents
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  • All nucleic 49
    Genomic 4
    cDNA 41
    Primer pair 2
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-9336, MGD-MRK-9337
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:16349 Nielsen PJ, et al., Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A. Nucleic Acids Res. 1985 Oct 11;13(19):6867-80
  • Latest
    J:224214 Truitt ML, et al., Differential Requirements for eIF4E Dose in Normal Development and Cancer. Cell. 2015 Jul 2;162(1):59-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory