Eif2b4
Gene Detail

Symbol Name ID

Eif2b4 eukaryotic translation initiation factor 2B, subunit 4 delta MGI:95300

Synonyms

Eif2b

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.24 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:31187558-31193430 bp, - strand From VEGA annotation of GRCm38   5873 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eif2b4

Human homologs

Human Homolog		EIF2B4, eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
NCBI Gene ID		8890
neXtProt AC		NX_Q9UI10
Human Synonyms		EIF2B, EIF-2B, EIF2Bdelta
Human Chr (Location)		2p23.3; chr2:27587219-27593324 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human EIF2B4

Alleles and phenotypes

All alleles(11) : Targeted(1) Gene trapped(10)

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cellular metabolic process, cellular response to stimulus, ...
Component	cytoplasm, eukaryotic translation initiation factor 2B complex
Function	guanyl-nucleotide exchange factor activity, translation initiation factor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (43)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	43

cDNA source data(96)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) cDNA(96)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022484 (Evidence)
Ensembl Gene Model	ENSMUSG00000029145 (Evidence)
Entrez Gene	13667 (Evidence)
UniGene	29394
DFCI	TC1575728, TC1606319
NIA Mouse Gene Index	U026062
Consensus CDS Project	CCDS19176.1, CCDS51457.1
International Mouse Knockout Project Status	Eif2b4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022484	VEGA Gene Model | MGI Sequence Detail	5873	C57BL/6J
transcript	OTTMUST00000053808	VEGA | MGI Sequence Detail	1767	Not Applicable
polypeptide	OTTMUSP00000025606	VEGA | MGI Sequence Detail	566	Not Applicable

All sequences(53) RefSeq(6) UniProt(3)

Polymorphisms

SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000649	Initiation factor 2B-related
Protein Ontology	PR:000006965	translation initiation factor eIF-2B subunit delta

References

(Earliest) J:21717 Henderson RA, et al., The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end. J Biol Chem. 1994 Dec 2;269(48):30517-23
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)

Other accession IDs

MGD-MRK-9333