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Eif2b4
Gene Detail
 Symbol
Name
ID
Eif2b4
eukaryotic translation initiation factor 2B, subunit 4 delta
MGI:95300
Synonyms Eif2b
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.24 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:31187558-31193430 bp, - strand
From VEGA annotation of GRCm38

  5873 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5976  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eif2b4

Human
homologs
Human Homolog EIF2B4, eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
NCBI Gene ID 8890
neXtProt AC  NX_Q9UI10
Human Synonyms  EIF2B, EIF-2B, EIF2Bdelta
Human Chr (Location)  2p23.3; chr2:27364352-27370457 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF2B4
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(10) Radiation induced(2) Targeted(4)
Genomic Mutations involving Eif2b4 (2)
Incidental mutations (data from Mutagenetix , APF )
Alleles Annotated to Human Diseases(1)   
Interactions
Eif2b4 interacts with 15 markers (Mir135a-2, Mir149, Mir346, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular metabolic process, cellular response to stimulus, ...
Component cytoplasm, eukaryotic translation initiation factor 2B complex
Function guanyl-nucleotide exchange factor activity, translation initiation factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (43)    Tissues (29)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 43
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(96) cDNA(96)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022484 (Evidence)
Ensembl Gene ModelENSMUSG00000029145 (Evidence)
Entrez Gene13667 (Evidence)
UniGene29394
DFCITC1575728, TC1606319
NIA Mouse Gene IndexU026062
Consensus CDS ProjectCCDS19176.1, CCDS51457.1
International Mouse Knockout Project StatusEif2b4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022484 VEGA Gene Model | MGI Sequence Detail 5873 C57BL/6J ±  kb
transcript OTTMUST00000053808 VEGA | MGI Sequence Detail 1767 Not Applicable 
polypeptide OTTMUSP00000025606 VEGA | MGI Sequence Detail 566 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000649 Initiation factor 2B-related
Protein Ontology PR:000006965 translation initiation factor eIF-2B subunit delta
References (Earliest) J:21717 Henderson RA, et al., The delta-subunit of murine guanine nucleotide exchange factor eIF-2B. Characterization of cDNAs predicts isoforms differing at the amino-terminal end. J Biol Chem. 1994 Dec 2;269(48):30517-23
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)
Other
accession IDs
MGD-MRK-9333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory