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Eif2s1 Gene Detail
Summary
  • Symbol
    Eif2s1
  • Name
    eukaryotic translation initiation factor 2, subunit 1 alpha
  • Synonyms
    0910001O23Rik, 2410026C18Rik, Eif2a, eIF2alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95299
    NCBI Gene: 13665
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:78908846-78933784 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 35.51 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    658 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95299
 protein coding gene Chr12:78908593-78933784 (+)
129S1/SvImJ ENSMUSG00200029405
 protein coding gene Chr12:70871925-70897113 (+)
A/J ENSMUSG00195029443
 protein coding gene Chr12:73571072-73596263 (+)
AKR/J ENSMUSG00220045457
 protein coding gene Chr12:71350852-71376047 (+)
BALB/cJ ENSMUSG00180018763
 protein coding gene Chr12:72543969-72569163 (+)
C3H/HeJ ENSMUSG00175035217
 protein coding gene Chr12:75703473-75728664 (+)
C57BL/6NJ ENSMUSG00215044777
 protein coding gene Chr12:71908042-71933233 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017881
 protein coding gene Chr12:73310986-73336310 (+)
CAST/EiJ ENSTCUG00005028965
 protein coding gene Chr12:71844598-71869632 (+)
CBA/J ENSMUSG00210045531
 protein coding gene Chr12:72117852-72143043 (+)
DBA/2J ENSMUSG00185039884
 protein coding gene Chr12:73978455-74003646 (+)
FVB/NJ ENSMUSG00205017462
 protein coding gene Chr12:71719984-71745175 (+)
JF1/MsJ ENSUMUG00000021306
 protein coding gene Chr12:77973331-77998485 (+)
LP/J ENSMUSG00230021100
 protein coding gene Chr12:80990101-81015289 (+)
NOD/ShiLtJ ENSMUSG00190011180
 protein coding gene Chr12:71175189-71200383 (+)
NZO/HlLtJ ENSMUSG00225049876
 protein coding gene Chr12:83048950-83074144 (+)
PWK/PhJ ENSLUMG00010027471
 protein coding gene Chr12:71990042-72015387 (+)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005042854
 protein coding gene Chr12:71803472-71828667 (+)



Homology
more
  • Human Ortholog
    EIF2S1, eukaryotic translation initiation factor 2 subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF2S1, eukaryotic translation initiation factor 2 subunit alpha
  • Synonyms
    EIF-2, EIF2, EIF-2A, EIF2A, EIF-2alpha
  • Links
    NCBI Gene ID: 1965
    UniProt: P05198

  • Chr Location
    14q23.3; chr14:67360011-67386516 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EIF2S1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality prior to organogenesis. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    83
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    898
  • Tissues
    52
  • cDNA Data
    176
  • Literature Summary
    66
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13665 NCBI Gene Model | MGI Sequence Detail 24939 C57BL/6J ±  kb
    transcript NM_026114 RefSeq | MGI Sequence Detail 3152 C57BL/6  
    polypeptide Q6ZWX6 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006971 eukaryotic translation initiation factor 2 subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR044126 IF2a, S1-like domain
      IPR012340 Nucleic acid-binding, OB-fold
      IPR003029 S1 domain
      IPR011488 Translation initiation factor 2, alpha subunit
      IPR024055 Translation initiation factor 2, alpha subunit, C-terminal
      IPR024054 Translation initiation factor 2, alpha subunit, middle domain superfamily
    • GlyGen
      Q6ZWX6 4 sites, 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 176
      Primer pair 1
      Antibodies 14

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9332, MGI:1914622, MGI:1923524
    References
    more
    • Summaries
      All 198
      Developmental Gene Expression 66
      Gene Ontology 26
      Phenotypes 65
    • Earliest
      J:10085 Disney JE, et al., High-mobility group protein HMG-I localizes to G/Q- and C-bands of human and mouse chromosomes. J Cell Biol. 1989 Nov;109(5):1975-82
    • Latest
      J:388187 Reineke LC, et al., Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response. Science. 2026 Apr 2;392(6793):eaea8782
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory