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Eif2s1 Gene Detail
Summary
  • Symbol
    Eif2s1
  • Name
    eukaryotic translation initiation factor 2, subunit 1 alpha
  • Synonyms
    0910001O23Rik, 2410026C18Rik, Eif2a, eIF2alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95299
    NCBI Gene: 13665
  • Gene Overview
    MyGene.info: EIF2S1
Location & Maps
more
  • Sequence Map
    Chr12:78861819-78887010 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25192 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 35.51 cM, cytoband D1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EIF2S1, eukaryotic translation initiation factor 2 subunit alpha
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EIF2S1, eukaryotic translation initiation factor 2 subunit alpha
    Orthology source: HomoloGene
  • Synonyms
    EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha
  • Links
    NCBI Gene ID: 1965
    neXtProt AC: NX_P05198

  • Chr Location
    14q23.3; chr14:67360317-67386516 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    67
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Targeted
    4
  • Genomic Mutations
    1 involving Eif2s1
  • Incidental Mutations
Mice homozygous for a knocked-in point mutation die within hours of birth and exhibit hypoglycemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031427 VEGA Gene Model | MGI Sequence Detail 25192 C57BL/6J ±  kb
transcript OTTMUST00000077865 VEGA | MGI Sequence Detail 3405 Not Applicable  
polypeptide OTTMUSP00000041277 VEGA | MGI Sequence Detail 315 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    203 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006971 eukaryotic translation initiation factor 2 subunit 1
  • InterPro Domains
    IPR012340 Nucleic acid-binding, OB-fold
    IPR022967 RNA-binding domain, S1
    IPR003029 S1 domain
    IPR011488 Translation initiation factor 2, alpha subunit
    IPR024055 Translation initiation factor 2, alpha subunit, C-terminal
    IPR024054 Translation initiation factor 2, alpha subunit, middle domain
Molecular
Reagents
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  • All nucleic 176
    cDNA 175
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-9332, MGI:1914622, MGI:1923524
References
more
  • Summaries
    All 67
    Developmental Gene Expression 5
    Gene Ontology 15
    Phenotypes 24
  • Earliest
    J:10085 Disney JE, et al., High-mobility group protein HMG-I localizes to G/Q- and C-bands of human and mouse chromosomes. J Cell Biol. 1989 Nov;109(5):1975-82
  • Latest
    J:226104 Wang F, et al., ASK1 mediates the teratogenicity of diabetes in the developing heart by inducing ER stress and inhibiting critical factors essential for cardiac development. Am J Physiol Endocrinol Metab. 2015 Sep 1;309(5):E487-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory