Eif2s1 MGI Mouse Gene Detail - MGI:95299 - eukaryotic translation initiation factor 2, subunit 1 alpha

Symbol

Eif2s1
Name

eukaryotic translation initiation factor 2, subunit 1 alpha
Synonyms

0910001O23Rik, 2410026C18Rik, Eif2a, eIF2alpha

Feature Type

protein coding gene
IDs

MGI:95299
NCBI Gene: 13665
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:78908846-78933784 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.51 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

201 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95299	protein coding gene	Chr12:78908593-78933784 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019874	protein coding gene	Chr12:79137984-79163159 (+)
A/J	MGP_AJ_G0019832	protein coding gene	Chr12:76288869-76314060 (+)
AKR/J	MGP_AKRJ_G0019807	protein coding gene	Chr12:78359039-78384223 (+)
BALB/cJ	MGP_BALBcJ_G0019811	protein coding gene	Chr12:76541717-76566964 (+)
C3H/HeJ	MGP_C3HHeJ_G0019617	protein coding gene	Chr12:78828161-78854830 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020263	protein coding gene	Chr12:81473857-81505158 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017881	protein coding gene	Chr12:73310986-73336310 (+)
CAST/EiJ	MGP_CASTEiJ_G0019167	protein coding gene	Chr12:73657362-73683192 (+)
CBA/J	MGP_CBAJ_G0019587	protein coding gene	Chr12:84644991-84670130 (+)
DBA/2J	MGP_DBA2J_G0019703	protein coding gene	Chr12:75915504-75941314 (+)
FVB/NJ	MGP_FVBNJ_G0019689	protein coding gene	Chr12:74726864-74752055 (+)
LP/J	MGP_LPJ_G0019775	protein coding gene	Chr12:79063578-79088764 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019728	protein coding gene	Chr12:87700974-87727925 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020299	protein coding gene	Chr12:77874775-77899964 (+)
PWK/PhJ	MGP_PWKPhJ_G0018933	protein coding gene	Chr12:70253626-70279877 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018727	protein coding gene	Chr12:72373421-72398814 (+)
WSB/EiJ	MGP_WSBEiJ_G0019220	protein coding gene	Chr12:78471626-78496791 (+)

Human Ortholog

EIF2S1, eukaryotic translation initiation factor 2 subunit alpha

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF2S1, eukaryotic translation initiation factor 2 subunit alpha
Synonyms

EIF2, EIF-2, EIF2A, EIF-2A, EIF-2alpha
Links

HGNC:3265

NCBI Gene ID: 1965

neXtProt AC: NX_P05198

UniProt: P05198
Chr Location

14q23.3; chr14:67360328-67386516 (+) GRCh38

MGI Vertebrate Homology

Eif2s1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EIF2S1
Gene Tree

Eif2s1

Diseases

1 with human EIF2S1 associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

61
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

52
Targeted

4
Transgenic

1
Genomic Mutations

1 involving Eif2s1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knocked-in point mutation die within hours of birth and exhibit hypoglycemia.

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All GO Annotations

43
GO References

20

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

27
cDNA Data

176
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif2s1

ZFIN eif2s1a, eif2s1b

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All Sequences

42
RefSeq

2
UniProt

2
CCDS

CCDS26003.1

Ensembl

ENSMUSG00000021116 (Evidence)
NCBI Gene

13665

			Length	Strain/Species	Flank
genomic	13665	NCBI Gene Model \| MGI Sequence Detail	24939	C57BL/6J	± kb
transcript	NM_026114	RefSeq \| MGI Sequence Detail	3152	C57BL/6
polypeptide	Q6ZWX6	UniProt \| EBI \| MGI Sequence Detail	315	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006971 eukaryotic translation initiation factor 2 subunit 1

(term hierarchy)
InterPro Domains

IPR044126 IF2a, S1-like domain

IPR012340 Nucleic acid-binding, OB-fold

IPR003029 S1 domain

IPR011488 Translation initiation factor 2, alpha subunit

IPR024055 Translation initiation factor 2, alpha subunit, C-terminal

IPR024054 Translation initiation factor 2, alpha subunit, middle domain superfamily

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All nucleic 177

cDNA 176

Primer pair 1

Microarray probesets 5

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MGD-MRK-9332, MGI:1914622, MGI:1923524

Summaries

All 123

Developmental Gene Expression 13

Gene Ontology 20

Phenotypes 50
Earliest

J:10085 Disney JE, et al., High-mobility group protein HMG-I localizes to G/Q- and C-bands of human and mouse chromosomes. J Cell Biol. 1989 Nov;109(5):1975-82
Latest

J:346137 Amiri M, et al., Impact of eIF2alpha phosphorylation on the translational landscape of mouse embryonic stem cells. Cell Rep. 2024 Jan 23;43(1):113615

TSS for Eif2s1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114065	Chr12:78907798-78907827 (+)	-1,033 bp
Tssr114066	Chr12:78908452-78908462 (+)	-389 bp
Tssr114067	Chr12:78908467-78908523 (+)	-351 bp
Tssr114068	Chr12:78908799-78908845 (+)	-24 bp
Tssr114069	Chr12:78908873-78908887 (+)	34 bp
Tssr114070	Chr12:78909313-78909328 (+)	475 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23