Klk1b22
Gene Detail

Symbol Name ID

Klk1b22 kallikrein 1-related peptidase b22 MGI:95291

Synonyms

Egfbp1, Egfbp-1, Klk22, mGk-22

Feature Type

protein coding gene

Genetic Map

Chromosome 7

28.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:44112673-44116922 bp, + strand From VEGA annotation of GRCm38   4250 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

Protein SuperFamily: trypsin
Gene Tree: Klk1b22

Human homologs

Human Homolog		KLK3, kallikrein-related peptidase 3
NCBI Gene ID		354
neXtProt AC		NX_P07288
Human Synonyms		APS, hK3, KLK2A1, PSA
Human Chr (Location)		19q13.41; chr19:51358171-51364020 (+)  GRCh37.p10

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	proteolysis, zymogen activation
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

cDNA source data(34)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(116) Genomic(82) cDNA(34)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000027243 (Evidence)
Ensembl Gene Model	ENSMUSG00000060177 (Evidence)
Entrez Gene	13646 (Evidence)
UniGene	5193
DFCI	TC1583968
DoTS	DT.94336347
NIA Mouse Gene Index	U226544
EC	3.4.21.35
Consensus CDS Project	CCDS21196.1
International Mouse Knockout Project Status	Klk1b22

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027243	VEGA Gene Model | MGI Sequence Detail	4250	C57BL/6J
transcript	OTTMUST00000067365	VEGA | MGI Sequence Detail	855	Not Applicable
polypeptide	OTTMUSP00000033884	VEGA | MGI Sequence Detail	259	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(136 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001254	Peptidase S1
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR018114	Peptidase S1, trypsin family, active site
InterPro	IPR009003	Trypsin-like cysteine/serine peptidase domain
Protein Ontology	PR:000009607	kallikrein 1-related peptidase b22

References

(Earliest) J:32315 Lundgren S, et al., Sequence of an epidermal growth factor-binding protein. J Biol Chem. 1984 Jun 25;259(12):7780-4
(Latest) J:111453 Lundwall A, et al., A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637-41
All references(27)

Other accession IDs

MGD-MRK-9316, MGD-MRK-9319