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Klk1b22
Gene Detail
Symbol

Name
ID
Klk1b22
kallikrein 1-related peptidase b22
MGI:95291
Synonyms
Egfbp1, Egfbp-1, Klk22, mGk-22
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:44112673-44116922 bp, + strand
From VEGA annotation of GRCm38

  4250 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68141  Vertebrate Homology Class
1 human; 14 mouse; 1 rhesus macaque

HCOP human homology predictions: KLK3
Protein SuperFamily: trypsin
Gene Tree: Klk1b22

Human
homologs
KLK3, kallikrein-related peptidase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 354
neXtProt AC: NX_P07288

Human Synonyms: APS, hK3, KLK2A1, PSA

Human Chr (Location): 19q13.41; chr19:50854915-50877702 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk1b22 interacts with 6 markers (Mir325, Mir665, Mir669h, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process proteolysis, zymogen activation
Component extracellular exosome, extracellular space, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(34)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(116) Genomic(82) cDNA(34)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000027243 (Evidence)
Ensembl Gene Model ENSMUSG00000060177 (Evidence)
Entrez Gene 13646 (Evidence)
UniGene 5193
DFCI TC1583968
DoTS DT.94336347
NIA Mouse Gene Index U226544
EC 3.4.21.35
Consensus CDS Project CCDS21196.1
International Mouse Phenotyping Consortium Status Klk1b22
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027243 VEGA Gene Model | MGI Sequence Detail 4250 C57BL/6J ±  kb
transcript OTTMUST00000067365 VEGA | MGI Sequence Detail 855 Not Applicable 
polypeptide OTTMUSP00000033884 VEGA | MGI Sequence Detail 259 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(185 from dbSNP Build 137)    SNPs within 2kb including multiple locations(187)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009607 kallikrein 1-related peptidase b22
References
(Earliest) J:32315 Lundgren S, et al., Sequence of an epidermal growth factor-binding protein. J Biol Chem. 1984 Jun 25;259(12):7780-4
(Latest) J:111453 Lundwall A, et al., A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637-41
All references(27)
Other
accession IDs
MGD-MRK-9316, MGD-MRK-9319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory