Eef2
Gene Detail

Symbol Name ID

Eef2 eukaryotic translation elongation factor 2 MGI:95288

Synonyms

Ef-2

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr10:81176631-81182507 bp, + strand From Ensembl annotation of GRCm38   5877 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:134867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eef2

Human homologs

Human Homolog		EEF2, eukaryotic translation elongation factor 2
NCBI Gene ID		1938
neXtProt AC		NX_P13639
Human Synonyms		EEF-2, EF2, EF-2, SCA26
Human Chr (Location)		19p13.3; chr19:3976056-3985463 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human EEF2

Alleles and phenotypes

All alleles(31) : Gene trapped(29) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	GTP catabolic process, hematopoietic progenitor cell differentiation, ...
Component	cytoplasm, extracellular vesicular exosome, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (8)    Tissues (4)   
Theiler Stages: 21, 23, 26, 28

Assay Type	Results
Northern blot	8

cDNA source data(64)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(68) Genomic(3) cDNA(65)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000034994 (Evidence)
Entrez Gene	13629 (Evidence)
DFCI	TC1573604, TC1672450
DoTS	DT.101140722, DT.101250825, DT.101255050, DT.101363495, DT.101363503, DT.101363771, DT.101741482, DT.103589673, DT.110623422, DT.110623535, DT.110623739, DT.91280433, DT.94229386, DT.94229430, DT.94229694, DT.94229763, DT.94263408, DT.94299057, DT.94355782, DT.97339230, DT.99872914
NIA Mouse Gene Index	U011775, U073786
Consensus CDS Project	CCDS35993.1
International Mouse Knockout Project Status	Eef2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000034994	Ensembl Gene Model | MGI Sequence Detail	5877	C57BL/6J
transcript	ENSMUST00000047864	Ensembl | MGI Sequence Detail	3098	Not Applicable
polypeptide	ENSMUSP00000046101	Ensembl | MGI Sequence Detail	858	Not Applicable

All sequences(486) RefSeq(2) UniProt(20)

Polymorphisms

SNPs within 2kb(48 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR009022	Elongation factor G, III-V domain
InterPro	IPR000795	Elongation factor, GTP-binding domain
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
InterPro	IPR020568	Ribosomal protein S5 domain 2-type fold
InterPro	IPR014721	Ribosomal protein S5 domain 2-type fold, subgroup
InterPro	IPR005225	Small GTP-binding protein domain
InterPro	IPR005517	Translation elongation factor EFG/EF2, domain IV
InterPro	IPR000640	Translation elongation factor EFG, V domain
InterPro	IPR004161	Translation elongation factor EFTu/EF1A, domain 2
InterPro	IPR009000	Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology	PR:000006909	elongation factor 2

References

(Earliest) J:10363 Ishiura M, et al., Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse. Gene. 1989 Dec 28;85(2):427-33
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(43)

Other accession IDs

MGD-MRK-9307, MGD-MRK-9309