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Eef2 Gene Detail
Summary
  • Symbol
    Eef2
  • Name
    eukaryotic translation elongation factor 2
  • Synonyms
    Ef-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95288
    NCBI Gene: 13629
  • Gene Overview
    MyGene.info: EEF2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:81176631-81182498 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5868 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EEF2, eukaryotic translation elongation factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EEF2, eukaryotic translation elongation factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EEF-2, EF2, EF-2, SCA26
  • Links
    NCBI Gene ID: 1938
    neXtProt AC: NX_P13639
    UniProt: P13639

  • Chr Location
    19p13.3; chr19:3976056-3985463 (-)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 134867
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EEF2
  • Gene Tree
    Eef2
Human Diseases
more
  • Diseases
    1 with human EEF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    1 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    33
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    8
  • Tissues
    4
  • cDNA Data
    64
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034994 Ensembl Gene Model | MGI Sequence Detail 5868 C57BL/6J ±  kb
transcript ENSMUST00000047864 Ensembl | MGI Sequence Detail 3089 Not Applicable  
polypeptide ENSMUSP00000046101 Ensembl | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
  • UniProt
    20 Sequences
  • Protein Ontology
    PR:000006909 elongation factor 2
    (term hierarchy)
  • InterPro Domains
    IPR035647 EF-G domain III/V-like
    IPR000640 Elongation factor EFG, domain V-like
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR005517 Translation elongation factor EFG/EF2, domain IV
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain superfamily
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
less
  • All nucleic 68
    Genomic 3
    cDNA 65

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9307, MGD-MRK-9309
References
more
  • Summaries
    All 53
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:234402 Liu S, et al., Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4079-87
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/17/2018
MGI 6.11 		The Jackson Laboratory