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Eef2 Gene Detail
Summary
  • Symbol
    Eef2
  • Name
    eukaryotic translation elongation factor 2
  • Synonyms
    Ef-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95288
    NCBI Gene: 13629
  • Gene Overview
    MyGene.info: EEF2
Location & Maps
more
  • Sequence Map
    Chr10:81176631-81182507 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5877 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EEF2, eukaryotic translation elongation factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EEF2, eukaryotic translation elongation factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EEF-2, EF2, EF-2, SCA26
  • Links
    NCBI Gene ID: 1938
    neXtProt AC: NX_P13639

  • Chr Location
    19p13.3; chr19:3976056-3985463 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 134867
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: EEF2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human EEF2 associations

Human Disease Mouse Models
       Spinocerebellar Ataxia 26; SCA26   OMIM: 609306
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    32
  • Chemically induced (other)
    1
  • Gene trapped
    29
  • Targeted
    2
  • Genomic Mutations
    1 involving Eef2
  • Incidental Mutations
Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034994 Ensembl Gene Model | MGI Sequence Detail 5877 C57BL/6J ±  kb
transcript ENSMUST00000047864 Ensembl | MGI Sequence Detail 3098 Not Applicable  
polypeptide ENSMUSP00000046101 Ensembl | MGI Sequence Detail 858 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
  • UniProt
    20 Sequences
  • Protein Ontology
    PR:000006909 elongation factor 2
  • InterPro Domains
    IPR009022 Elongation factor G, III-V domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR020568 Ribosomal protein S5 domain 2-type fold
    IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
    IPR005225 Small GTP-binding protein domain
    IPR000795 Transcription factor, GTP-binding domain
    IPR005517 Translation elongation factor EFG/EF2, domain IV
    IPR000640 Translation elongation factor EFG, V domain
    IPR004161 Translation elongation factor EFTu-like, domain 2
    IPR009000 Translation protein, beta-barrel domain
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
less
  • All nucleic 68
    Genomic 3
    cDNA 65

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9307, MGD-MRK-9309
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 12
  • Earliest
    J:10363 Ishiura M, et al., Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse. Gene. 1989 Dec 28;85(2):427-33
  • Latest
    J:216392 Kraushar ML, et al., Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R. Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3815-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory