Eef2 MGI Mouse Gene Detail - MGI:95288 - eukaryotic translation elongation factor 2

Eef2 Gene Detail

Symbol

Eef2
Name

eukaryotic translation elongation factor 2
Synonyms

Ef-2

Feature Type

protein coding gene
IDs

MGI:95288
NCBI Gene: 13629
Gene Overview

MyGene.info: EEF2

Sequence Map

Chr10:81176631-81182507 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

5877 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

2 experiments

Human Ortholog

EEF2, eukaryotic translation elongation factor 2

Vertebrate Orthologs

10

Human Ortholog

EEF2, eukaryotic translation elongation factor 2
Orthology source: HomoloGene, HGNC
Synonyms

EEF-2, EF2, EF-2, SCA26
Links

HGNC:3214

NCBI Gene ID: 1938

neXtProt AC: NX_P13639
Chr Location

19p13.3; chr19:3976056-3985463 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 134867
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: EEF2
Gene Tree

Eef2

Diseases

1 with human EEF2 associations

				Human Disease	Mouse Models
				Spinocerebellar Ataxia 26; SCA26 OMIM: 609306

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
1 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Gene trapped

29
Targeted

2
Genomic Mutations

1 involving Eef2
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology.

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All GO Annotations

37
GO References

9

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

8
Tissues

4
cDNA Data

64
Literature Summary

5

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase eef2.1, eef2.2

ZFIN eef2a.1, eef2b

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Eef2 interacts with 50 markers (Mir190b, Mir301, Mir301b, ...) View All

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All Sequences

507
RefSeq

2
UniProt

20
CCDS

CCDS35993.1

Ensembl

ENSMUSG00000034994 (Evidence)
NCBI Gene

13629

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034994	Ensembl Gene Model \| MGI Sequence Detail	5877	C57BL/6J	± kb
transcript	ENSMUST00000047864	Ensembl \| MGI Sequence Detail	3098	Not Applicable
polypeptide	ENSMUSP00000046101	Ensembl \| MGI Sequence Detail	858	Not Applicable

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SNPs within 2kb

48 from dbSNP Build 142

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UniProt

20 Sequences
Protein Ontology

PR:000006909 elongation factor 2
InterPro Domains

IPR009022 Elongation factor G, III-V domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR020568 Ribosomal protein S5 domain 2-type fold

IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

IPR005225 Small GTP-binding protein domain

IPR000795 Transcription factor, GTP-binding domain

IPR005517 Translation elongation factor EFG/EF2, domain IV

IPR000640 Translation elongation factor EFG, V domain

IPR004161 Translation elongation factor EFTu-like, domain 2

IPR009000 Translation protein, beta-barrel domain

IPR031157 Tr-type G domain, conserved site

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All nucleic 68

Genomic 3

cDNA 65

Microarray probesets 3

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MGD-MRK-9307, MGD-MRK-9309

Summaries

All 43

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 13
Earliest

J:10363 Ishiura M, et al., Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse. Gene. 1989 Dec 28;85(2):427-33
Latest

J:234402 Liu S, et al., Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4079-87

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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