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Gene Detail
eukaryotic translation elongation factor 2
Synonyms Ef-2
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr10:81176631-81182507 bp, + strand
From Ensembl annotation of GRCm38

  5877 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:134867  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eef2

Human Homolog EEF2, eukaryotic translation elongation factor 2
NCBI Gene ID 1938
neXtProt AC  NX_P13639
Human Synonyms  EEF-2, EF2, EF-2, SCA26
Human Chr (Location)  19p13.3; chr19:3976056-3985463 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EEF2
alleles, and
All mutations/alleles(31) : Gene trapped(29) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a mutation removing the diphthamide modification display partial neonatal lethality, fetal growth retardation and abnormal cell physiology.
Phenotype Images(1)
Eef2 interacts with 50 markers (Mir190b, Mir301, Mir301b, ...)
Gene Ontology
All GO classifications: (22 annotations)
Process GTP catabolic process, hematopoietic progenitor cell differentiation, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Literature Summary: (4 records)
Data Summary: Results (8)    Tissues (4)   
Theiler Stages: 21, 23, 26, 28
Assay TypeResults
Northern blot 8
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(68) Genomic(3) cDNA(65)
Microarray probesets(3)
Other database
Ensembl Gene ModelENSMUSG00000034994 (Evidence)
Entrez Gene13629 (Evidence)
DFCITC1573604, TC1672450
DoTSDT.101140722, DT.101250825, DT.101255050, DT.101363495, DT.101363503, DT.101363771, DT.101741482, DT.103589673, DT.110623422, DT.110623535, DT.110623739, DT.91280433, DT.94229386, DT.94229430, DT.94229694, DT.94229763, DT.94263408, DT.94299057, DT.94355782, DT.97339230, DT.99872914
NIA Mouse Gene IndexU011775, U073786
Consensus CDS ProjectCCDS35993.1
International Mouse Knockout Project StatusEef2
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034994 Ensembl Gene Model | MGI Sequence Detail 5877 C57BL/6J ±  kb
transcript ENSMUST00000047864 Ensembl | MGI Sequence Detail 3098 Not Applicable 
polypeptide ENSMUSP00000046101 Ensembl | MGI Sequence Detail 858 Not Applicable 

For the selected sequences
All sequences(486) RefSeq(2) UniProt(20)
Polymorphisms SNPs within 2kb(48 from dbSNP Build 137)
InterPro IPR009022 Elongation factor G, III-V domain
InterPro IPR000795 Elongation factor, GTP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR020568 Ribosomal protein S5 domain 2-type fold
InterPro IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup
InterPro IPR005225 Small GTP-binding protein domain
InterPro IPR005517 Translation elongation factor EFG/EF2, domain IV
InterPro IPR000640 Translation elongation factor EFG, V domain
InterPro IPR004161 Translation elongation factor EFTu/EF1A, domain 2
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000006909 elongation factor 2
References (Earliest) J:10363 Ishiura M, et al., Simplified cosmid vectors for gene transfer to cultured mammalian cells: isolation of the gene for elongation factor 2 from the mouse. Gene. 1989 Dec 28;85(2):427-33
(Latest) J:202604 Nagamachi A, et al., Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell. 2013 Sep 9;24(3):305-17
All references(43)
accession IDs
MGD-MRK-9307, MGD-MRK-9309

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory