About   Help   FAQ
Eed
Gene Detail
Symbol

Name
ID
Eed
embryonic ectoderm development
MGI:95286
Synonyms
l(7)5Rn, l7Rn5
Feature Type
protein coding gene
Genetic Map
Chromosome 7
50.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:89954656-89980983 bp, - strand
From VEGA annotation of GRCm38

  26328 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Eed

Human
homologs
Human Homolog EED, embryonic ectoderm development
NCBI Gene ID 8726
neXtProt AC  NX_O75530
Human Synonyms  HEED, WAIT1
Human Chr (Location)  11q14.2-q22.3; chr11:86244544-86285420 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(120) : Chemically induced (ENU)(4) Gene trapped(113) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are dwarfed and their coat color is dilute.
 
Interactions
Eed interacts with 89 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process chromatin modification, histone methylation, ...
Component chromosome, cytoplasm, ...
Function chromatin binding, histone methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (228)    Tissues (93)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
RT-PCR 36
cDNA source data(90)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(106) Genomic(4) cDNA(92) Primer pair(1) Other(9)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021134 (Evidence)
Ensembl Gene ModelENSMUSG00000030619 (Evidence)
Entrez Gene13626 (Evidence)
UniGene380914
DFCITC1577539
DoTSDT.493310
NIA Mouse Gene IndexU028847
PDB2QXV
Consensus CDS ProjectCCDS40016.1
International Mouse Knockout Project StatusEed
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021134 VEGA Gene Model | MGI Sequence Detail 26328 C57BL/6J ±  kb
transcript OTTMUST00000050031 VEGA | MGI Sequence Detail 2065 Not Applicable 
polypeptide OTTMUSP00000023294 VEGA | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000006902 polycomb protein EED
References
(Earliest) J:2961 Sharan SK, et al., The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm. Genetics. 1991 Nov;129(3):825-32
(Latest) J:205911 Ferrari KJ, et al., Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity. Mol Cell. 2014 Jan 9;53(1):49-62
All references(121)
Other
accession IDs
MGD-MRK-11693, MGD-MRK-11725, MGD-MRK-9305, MGI:3584396, MGI:3641985, MGI:96737

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/11/2014
MGI 5.20
The Jackson Laboratory