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Eed
Gene Detail
Symbol

Name
ID
Eed
embryonic ectoderm development
MGI:95286
Synonyms
l(7)5Rn, l7Rn5
Feature Type
protein coding gene
Genetic Map
Chromosome 7
50.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr7:89954656-89980983 bp, - strand
From VEGA annotation of GRCm38

  26328 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2814  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EED
Gene Tree: Eed

Human
homologs
EED, embryonic ectoderm development
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8726
neXtProt AC: NX_O75530

Human Synonyms: HEED, WAIT1

Human Chr (Location): 11q14.2-q22.3; chr11:86244544-86285420 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(120) : Chemically induced (ENU)(4) Gene trapped(113) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are dwarfed and their coat color is dilute.
 
Interactions
Eed interacts with 89 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process chromatin modification, histone methylation, ...
Component chromosome, cytoplasm, ...
Function chromatin binding, histone methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (228)    Tissues (93)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 192
RT-PCR 36
cDNA source data(90)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase eed    NEW 
Molecular
reagents
All nucleic(106) Genomic(4) cDNA(92) Primer pair(1) Other(9)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021134 (Evidence)
Ensembl Gene Model ENSMUSG00000030619 (Evidence)
Entrez Gene 13626 (Evidence)
UniGene 380914
DFCI TC1577539
DoTS DT.493310
NIA Mouse Gene Index U028847
PDB 2QXV
Consensus CDS Project CCDS40016.1
International Mouse Phenotyping Consortium Status Eed
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021134 VEGA Gene Model | MGI Sequence Detail 26328 C57BL/6J ±  kb
transcript OTTMUST00000050031 VEGA | MGI Sequence Detail 2065 Not Applicable 
polypeptide OTTMUSP00000023294 VEGA | MGI Sequence Detail 441 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(215 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000006902 polycomb protein EED
References
(Earliest) J:2961 Sharan SK, et al., The albino-deletion complex of the mouse: molecular mapping of deletion breakpoints that define regions necessary for development of the embryonic and extraembryonic ectoderm. Genetics. 1991 Nov;129(3):825-32
(Latest) J:218057 Zheng HJ, et al., The Novel Helicase helG (DHX30) Is Expressed During Gastrulation in Mice and Has a Structure Similar to a Human DExH Box Helicase. Stem Cells Dev. 2015 Feb 1;24(3):372-83
All references(122)
Other
accession IDs
MGD-MRK-11693, MGD-MRK-11725, MGD-MRK-9305, MGI:3584396, MGI:3641985, MGI:96737

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory