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Eed Gene Detail
Summary
  • Symbol
    Eed
  • Name
    embryonic ectoderm development
  • Synonyms
    l(7)5Rn, l7Rn5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95286
    NCBI Gene: 13626
  • Gene Overview
    MyGene.info: EED
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:89954654-89980983 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      26330 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 50.42 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    EED, embryonic ectoderm development
  • Vertebrate Orthologs
    9
  • Human Ortholog
    EED, embryonic ectoderm development
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COGIS, HEED, WAIT1
  • Links
    NCBI Gene ID: 8726
    neXtProt AC: NX_O75530
    UniProt: O75530

  • Chr Location
    11q14.2; chr11:86244384-86285420 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2814
    1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EED
  • Gene Tree
    Eed
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are dwarfed and their coat color is dilute.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021134 VEGA Gene Model | MGI Sequence Detail 26330 C57BL/6J ±  kb
    transcript OTTMUST00000050031 VEGA | MGI Sequence Detail 2067 Not Applicable  
    polypeptide OTTMUSP00000023294 VEGA | MGI Sequence Detail 441 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      214 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      Genomic 4
      cDNA 95
      Primer pair 1
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11693, MGD-MRK-11725, MGD-MRK-9305, MGI:3584396, MGI:3641985, MGI:96737
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 32
      Gene Ontology 31
      Phenotypes 72
    • Earliest
      J:141526 Russell LB, et al., Analysis of the albino-locus region of the mouse. III. Time of death of prenatal lethals. Genetics. 1979 May;92(1):205-13
    • Latest
      J:264141 Zhang L, et al., EED, a member of the polycomb group, is required for nephron differentiation and the maintenance of nephron progenitor cells. Development. 2018 Jul 18;145(14)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/16/2018
    MGI 6.12
    The Jackson Laboratory