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Ect2 Gene Detail
Summary
  • Symbol
    Ect2
  • Name
    ect2 oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:95281
    NCBI Gene: 13605
  • Gene Overview
    MyGene.info: ECT2
Location & Maps
more
  • Sequence Map
    Chr3:27097222-27153878 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      56657 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 10.82 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ECT2, epithelial cell transforming 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ECT2, epithelial cell transforming 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHGEF31
  • Links
    NCBI Gene ID: 1894
    neXtProt AC: NX_Q9H8V3

  • Chr Location
    3q26.1-q26.2; chr3:172750682-172829265 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7298
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: ECT2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    48
  • Gene trapped
    40
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    1 involving Ect2
  • Incidental Mutations
Homozygous disruption of this locus is embryonic lethal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021265 VEGA Gene Model | MGI Sequence Detail 56657 C57BL/6J ±  kb
transcript OTTMUST00000050393 VEGA | MGI Sequence Detail 4086 Not Applicable  
polypeptide OTTMUSP00000023513 VEGA | MGI Sequence Detail 913 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    242 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 141
    Genomic 1
    cDNA 139
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-9296, MGI:2139751
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory