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Ect2
Gene Detail
 Symbol
Name
ID
Ect2
ect2 oncogene
MGI:95281
Feature Type protein coding gene
Genetic Map
Chromosome 3
10.82 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:27097222-27153878 bp, - strand
From VEGA annotation of GRCm38

  56657 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ect2

Human
homologs
Human Homolog ECT2, epithelial cell transforming 2
NCBI Gene ID 1894
neXtProt AC  NX_Q9H8V3
Human Synonyms  ARHGEF31
Human Chr (Location)  3q26.1-q26.2; chr3:172750646-172829265 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(40) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this locus is embryonic lethal.
 
Interactions
Ect2 interacts with 69 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process activation of protein kinase activity, activation of Rac GTPase activity, ...
Component cell-cell junction, cell junction, ...
Function GTPase activator activity, guanyl-nucleotide exchange factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (70)    Tissues (7)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 70
cDNA source data(139)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(141) Genomic(1) cDNA(139) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021265 (Evidence)
Ensembl Gene ModelENSMUSG00000027699 (Evidence)
Entrez Gene13605 (Evidence)
UniGene261453
DFCITC1575723, TC1585159, TC1593131, TC1624519
NIA Mouse Gene IndexU023897
PDB2COU
Consensus CDS ProjectCCDS17270.2, CCDS50875.1
International Mouse Knockout Project StatusEct2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021265 VEGA Gene Model | MGI Sequence Detail 56657 C57BL/6J ±  kb
transcript OTTMUST00000050393 VEGA | MGI Sequence Detail 4086 Not Applicable 
polypeptide OTTMUSP00000023513 VEGA | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(10) UniProt(8)
Polymorphisms SNPs within 2kb(244 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR026817 Guanine nucleotide exchange factor Ect2
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006885 protein ECT2
References (Earliest) J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(46)
Other
accession IDs
MGD-MRK-9296, MGI:2139751

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory