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Ect2
Gene Detail
Symbol

Name
ID
Ect2
ect2 oncogene
MGI:95281
Feature Type
protein coding gene
Genetic Map
Chromosome 3
10.82 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:27097222-27153878 bp, - strand
From VEGA annotation of GRCm38

  56657 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7298  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ECT2
Gene Tree: Ect2

Human
homologs
ECT2, epithelial cell transforming 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1894
neXtProt AC: NX_Q9H8V3

Human Synonyms: ARHGEF31

Human Chr (Location): 3q26.1-q26.2; chr3:172750682-172829265 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(47) : Gene trapped(40) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous disruption of this locus is embryonic lethal.
 
Interactions
Ect2 interacts with 69 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (70)    Tissues (7)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 70
cDNA source data(139)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ECT2 ; Xenbase ect2 ; ZFIN ect2    NEW 
Molecular
reagents
All nucleic(141) Genomic(1) cDNA(139) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021265 (Evidence)
Ensembl Gene Model ENSMUSG00000027699 (Evidence)
Entrez Gene 13605 (Evidence)
UniGene 261453
DFCI TC1575723, TC1585159, TC1593131, TC1624519
NIA Mouse Gene Index U023897
PDB 2COU
Consensus CDS Project CCDS17270.2, CCDS50875.1
International Mouse Phenotyping Consortium Status Ect2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021265 VEGA Gene Model | MGI Sequence Detail 56657 C57BL/6J ±  kb
transcript OTTMUST00000050393 VEGA | MGI Sequence Detail 4086 Not Applicable 
polypeptide OTTMUSP00000023513 VEGA | MGI Sequence Detail 913 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(244 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001357 BRCT domain
InterPro IPR000219 Dbl homology (DH) domain
InterPro IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
InterPro IPR026817 Guanine nucleotide exchange factor Ect2
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000006885 protein ECT2
References
(Earliest) J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(46)
Other
accession IDs
MGD-MRK-9296, MGI:2139751

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory