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Epha7
Gene Detail
Symbol

Name
ID
Epha7
Eph receptor A7
MGI:95276
Synonyms
Cek11, Ebk, Ehk3, Hek11, Mdk1, MDK1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
12.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr4:28813131-28967499 bp, + strand
From VEGA annotation of GRCm38

  154369 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20935  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPHA7
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha7

Human
homologs
EPHA7, EPH receptor A7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2045
neXtProt AC: NX_Q15375

Human Synonyms: EHK3, EHK-3, EK11, HEK11

Human Chr (Location): 6q16.1; chr6:93240020-93419584 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Some homozygous mutants display anencephaly. Mutants also exhibit increased proliferation of neural progenitor cells in the lateral ventricle wall of the adult brain.
 
Interactions
Epha7 interacts with 507 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process apoptotic process, brain development, ...
Component dendrite, integral component of membrane, ...
Function ATP binding, axon guidance receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (776)    Tissues (409)    Images (128)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 724
Northern blot 8
RT-PCR 14
RNase protection 1
cDNA source data(78)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EPHA7 ; Xenbase epha7 ; ZFIN epha7    NEW 
Molecular
reagents
All nucleic(93) cDNA(79) Primer pair(7) Other(7)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000004869 (Evidence)
Ensembl Gene Model ENSMUSG00000028289 (Evidence)
Entrez Gene 13841 (Evidence)
UniGene 257266
DFCI TC1579340, TC1587472, TC1595382, TC1595952, TC1598575, TC1620569, TC1699567
DoTS DT.55282326, DT.94262715, DT.97393384, DT.99854784
NIA Mouse Gene Index U004141, U200158
EC 2.7.10.1
Consensus CDS Project CCDS18013.1, CCDS51132.1, CCDS71353.1
International Mouse Phenotyping Consortium Status Epha7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004869 VEGA Gene Model | MGI Sequence Detail 154369 C57BL/6J ±  kb
transcript OTTMUST00000010880 VEGA | MGI Sequence Detail 6746 Not Applicable 
polypeptide OTTMUSP00000005092 VEGA | MGI Sequence Detail 998 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(12) UniProt(6)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(755 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR027936 Ephrin receptor, transmembrane domain
InterPro IPR016257 Ephrin receptor type-A /type-B
InterPro IPR003961 Fibronectin type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007127 ephrin type-A receptor 7
References
(Earliest) J:22410 Ciossek T, et al., Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene. 1995 Jan 5;10(1):97-108
(Latest) J:217584 Gerstmann K, et al., Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. Development. 2015 Jan 1;142(1):140-50
All references(111)
Other
accession IDs
MGD-MRK-9291

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory