About   Help   FAQ
Drd5
Gene Detail
Symbol

Name
ID
Drd5
dopamine receptor D5
MGI:94927
STS
Synonyms
D5R, Drd1b, DRD1b, Drd-5, Gpcr1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
20.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr5:38319509-38322310 bp, + strand
From NCBI annotation of GRCm38

  2802 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20216  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DRD5
Protein SuperFamily: D1-like dopamine receptor
Gene Tree: Drd5

Human
homologs
DRD5, dopamine receptor D5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1816
neXtProt AC: NX_P21918

Human Synonyms: DBDR, DRD1B, DRD1L2

Human Chr (Location): 4p16.1; chr4:9781634-9784009 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human DRD5

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Radiation induced(2) Targeted(7)
Genomic Mutations involving Drd5 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Drd5 interacts with 157 markers (Mir7-1, Mir10a, Mir15a, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (303)    Tissues (98)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 77
In situ reporter (knock in) 50
RT-PCR 176
cDNA source data(9)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(1)
Other database
links
Ensembl Gene Model ENSMUSG00000039358 (Evidence)
Entrez Gene 13492 (Evidence)
UniGene 167154
DFCI TC1588059
DoTS DT.91586598
NIA Mouse Gene Index U040636
Consensus CDS Project CCDS19255.1
International Mouse Phenotyping Consortium Status Drd5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13492 NCBI Gene Model | MGI Sequence Detail 2802 C57BL/6J ±  kb
transcript NM_013503 RefSeq | MGI Sequence Detail 3015 C57BL/6 
polypeptide Q8BLD9 UniProt | EBI | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000497 Dopamine D5 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001176 D(1B) dopamine receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:32765 Tiberi M, et al., Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7491-5
(Latest) J:216657 Ennis RC, et al., Dopamine D1-like receptors regulate the alpha1A-adrenergic receptor in human renal proximal tubule cells and D1-like dopamine receptor knockout mice. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1238-48
All references(73)
Other
accession IDs
MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory