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Drd5 Gene Detail
Summary
  • Symbol
    Drd5
  • Name
    dopamine receptor D5
  • Synonyms
    D5R, Drd1b, DRD1b, Drd-5, Gpcr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94927
    NCBI Gene: 13492
  • Gene Overview
    MyGene.info: DRD5
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:38319509-38322523 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 20.40 cM
  • Mapping Data
    13 experiments
  • Sequence Tag
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94927
protein coding gene Chr5:38319367-38322523 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029511
protein coding gene Chr5:36728085-36731236 (+)
A/J MGP_AJ_G0029477
protein coding gene Chr5:35503448-35506601 (+)
AKR/J MGP_AKRJ_G0029427
protein coding gene Chr5:36835560-36838715 (+)
BALB/cJ MGP_BALBcJ_G0029488
protein coding gene Chr5:35992616-35995768 (+)
C3H/HeJ MGP_C3HHeJ_G0029211
protein coding gene Chr5:36824422-36827572 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029942
protein coding gene Chr5:38670885-38674036 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027180
protein coding gene Chr5:33176364-33179526 (+)
CAST/EiJ MGP_CASTEiJ_G0028619
protein coding gene Chr5:35995044-35998203 (+)
CBA/J MGP_CBAJ_G0029178
protein coding gene Chr5:39587686-39593509 (+)
DBA/2J MGP_DBA2J_G0029325
protein coding gene Chr5:35624311-35627462 (+)
FVB/NJ MGP_FVBNJ_G0029284
protein coding gene Chr5:35107126-35110284 (+)
LP/J MGP_LPJ_G0029411
protein coding gene Chr5:37177893-37181044 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029314
protein coding gene Chr5:40307057-40310208 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029975
protein coding gene Chr5:36323406-36326552 (+)
PWK/PhJ MGP_PWKPhJ_G0028343
protein coding gene Chr5:34791132-34794271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028177
protein coding gene Chr5:35772689-35775836 (+)
WSB/EiJ MGP_WSBEiJ_G0028700
protein coding gene Chr5:36403546-36406694 (+)



Homology
more
  • Human Ortholog
    DRD5, dopamine receptor D5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DRD5, dopamine receptor D5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBDR, DRD1B, DRD1L2
  • Links
    NCBI Gene ID: 1816
    neXtProt AC: NX_P21918
    UniProt: P21918

  • Chr Location
    4p16.1; chr4:9781634-9784009 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DRD5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13492 NCBI Gene Model | MGI Sequence Detail 3015 C57BL/6J ±  kb
    transcript NM_013503 RefSeq | MGI Sequence Detail 3015 C57BL/6  
    polypeptide Q8BLD9 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 12
      Primer pair 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 16
      Phenotypes 44
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:254292 Megat S, et al., A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice. J Neurosci. 2018 Jan 10;38(2):379-397

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory