About   Help   FAQ
Drd5 Gene Detail
Summary
  • Symbol
    Drd5
  • Name
    dopamine receptor D5
  • Synonyms
    D5R, Drd1b, DRD1b, Drd-5, Gpcr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94927
    NCBI Gene: 13492
  • Gene Overview
    MyGene.info: DRD5
Location & Maps
more
  • Sequence Map
    Chr5:38319367-38322518 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3152 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 20.40 cM
  • Mapping Data
    13 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    DRD5, dopamine receptor D5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DRD5, dopamine receptor D5
    Orthology source: HomoloGene
  • Synonyms
    DBDR, DRD1B, DRD1L2
  • Links
    NCBI Gene ID: 1816
    neXtProt AC: NX_P21918

  • Chr Location
    4p16.1; chr4:9781634-9784009 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with human DRD5 associations

Human Disease Mouse Models
       Attention Deficit-Hyperactivity Disorder; ADHD   OMIM: 143465
Blepharospasm, Benign Essential   OMIM: 606798
Dopamine Receptor D5; DRD5   OMIM: 126453
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 5 alleles in 7 genetic backgrounds
    3 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    7
  • Genomic Mutations
    6 involving Drd5
  • Incidental Mutations
Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone. Mice homozygous for another knock-out allele exhibit increased methamphetamine-induced ambulatory activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056102 VEGA Gene Model | MGI Sequence Detail 3152 C57BL/6J ±  kb
transcript OTTMUST00000138723 VEGA | MGI Sequence Detail 3152 Not Applicable  
polypeptide OTTMUSP00000072893 VEGA | MGI Sequence Detail 478 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    43 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001176 D(1B) dopamine receptor
  • InterPro Domains
    IPR000497 Dopamine D5 receptor
    IPR000929 Dopamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 10
    Primer pair 3

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900
References
more
  • Summaries
    All 71
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 15
    Phenotypes 41
  • Earliest
    J:32765 Tiberi M, et al., Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7491-5
  • Latest
    J:216657 Ennis RC, et al., Dopamine D1-like receptors regulate the alpha1A-adrenergic receptor in human renal proximal tubule cells and D1-like dopamine receptor knockout mice. Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1238-48

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory