Drd5
Gene Detail

Symbol Name ID

Drd5 dopamine receptor D5 MGI:94927

STS

D5Dmo4

Synonyms

D5R, Drd1b, DRD1b, Drd-5, Gpcr1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

20.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr5:38319509-38322310 bp, + strand From NCBI annotation of GRCm38   2802 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Drd5 ± 2 cM)

Protein SuperFamily: D1-like dopamine receptor
Gene Tree: Drd5

Human ortholog

DRD5 dopamine receptor D5 NCBI Gene ID 1816
Human Synonyms: DBDR, DRD1B, DRD1L2
Human Chr4:9783258-9785633 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human DRD5 (3)

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice develop hypertension and exhibit elevated blood pressure caused by increased sympathetic tone.

 

Gene Ontology (GO) classifications

All GO classifications: (58 annotations)

Process	adenylate cyclase-activating dopamine receptor signaling pathway, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	axon, brush border membrane, ...
Function	dopamine binding, dopamine neurotransmitter receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (303)    Tissues (98)    Images (37)
Theiler Stages: 19, 23, 28

Assay Type	Results
RNA in situ	77
In situ reporter (knock in)	50
RT-PCR	176

cDNA source data(9)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(1) cDNA(10) Primer pair(3)
Microarray probesets(1)

Other database links

Ensembl Gene Model	ENSMUSG00000039358 (Evidence)
Entrez Gene	13492 (Evidence)
UniGene	167154
DFCI	TC1588059
DoTS	DT.91586598
NIA Mouse Gene Index	U040636
Consensus CDS Project	CCDS19255.1
International Mouse Knockout Project Status	Drd5

Sequences

Length	Strain/Species
genomic	13492	NCBI Gene Model | MGI Sequence Detail	2802	C57BL/6J
transcript	NM_013503	RefSeq | MGI Sequence Detail	2802	C57BL/6
polypeptide	Q8BLD9	UniProt | EBI | MGI Sequence Detail	478	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000497	Dopamine 1B receptor
InterPro	IPR000929	Dopamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001176	D(1B) dopamine receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:32765 Tiberi M, et al., Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7491-5
(Latest) J:185955 Jackson CR, et al., Retinal Dopamine Mediates Multiple Dimensions of Light-Adapted Vision. J Neurosci. 2012 Jul 4;32(27):9359-9368
All references(69)

Other accession IDs

MGD-MRK-16351, MGD-MRK-16359, MGD-MRK-8895, MGD-MRK-8900