Drd4
Gene Detail

Symbol Name ID

Drd4 dopamine receptor D4 MGI:94926

Synonyms

D4R, Drd-4

Feature Type

protein coding gene

Genetic Map

Chromosome 7

86.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:141292006-141294999 bp, + strand From Ensembl annotation of GRCm38   2994 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20215  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 2 zebrafish

Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd4

Human homologs

Human Homolog		DRD4, dopamine receptor D4
NCBI Gene ID		1815
neXtProt AC		NX_P21917
Human Synonyms		D4DR
Human Chr (Location)		11p15.5; chr11:637305-640706 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human DRD4

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygous mutants are less active in open field tests and have reduced responses to novelty, but they are locomotor supersensitivity to ethanol, cocaine, and methamphetamine.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	activation of MAPK activity, adenylate cyclase-inhibiting dopamine receptor signaling pathway, ...
Component	axon, cell cortex, ...
Function	dopamine binding, dopamine neurotransmitter receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (247)    Tissues (162)    Images (17)
Theiler Stages: 19, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	135
RT-PCR	112

cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(3) cDNA(13) Primer pair(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000025496 (Evidence)
Entrez Gene	13491 (Evidence)
UniGene	41075
DFCI	TC1586290, TC1597652
DoTS	DT.60101540
NIA Mouse Gene Index	U008955
Consensus CDS Project	CCDS22007.1
International Mouse Knockout Project Status	Drd4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025496	Ensembl Gene Model | MGI Sequence Detail	2994	C57BL/6J
transcript	ENSMUST00000026569	Ensembl | MGI Sequence Detail	1334	Not Applicable
polypeptide	ENSMUSP00000026569	Ensembl | MGI Sequence Detail	387	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002185	Dopamine D4 receptor
InterPro	IPR000929	Dopamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001179	D(4) dopamine receptor

References

(Earliest) J:22009 Rao PA, et al., Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 1994 Nov;51(11):912-7
(Latest) J:193918 Grady DL, et al., DRD4 genotype predicts longevity in mouse and human. J Neurosci. 2013 Jan 2;33(1):286-91
All references(78)

Other accession IDs

MGD-MRK-8894, MGD-MRK-8899, MGI:2142209