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Drd4
Gene Detail
 Symbol
Name
ID
Drd4
dopamine receptor D4
MGI:94926
Synonyms D4R, Drd-4
Feature Type protein coding gene
Genetic Map
Chromosome 7
86.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:141292006-141294999 bp, + strand
From Ensembl annotation of GRCm38

  2994 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20215  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd4

Human
homologs
Human Homolog DRD4, dopamine receptor D4
NCBI Gene ID 1815
neXtProt AC  NX_P21917
Human Synonyms  D4DR
Human Chr (Location)  11p15.5; chr11:637305-640706 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DRD4
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from APF )
 
Homozygous mutants are less active in open field tests and have reduced responses to novelty, but they are locomotor supersensitivity to ethanol, cocaine, and methamphetamine.
 
Interactions
Drd4 interacts with 13 markers (Mir130a, Mir140, Mir203, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process activation of MAPK activity, adenylate cyclase-inhibiting dopamine receptor signaling pathway, ...
Component axon, axon terminus, ...
Function dopamine binding, dopamine neurotransmitter receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (247)    Tissues (162)    Images (17)
Theiler Stages: 19, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 135
RT-PCR 112
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) Genomic(3) cDNA(13) Primer pair(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025496 (Evidence)
Entrez Gene13491 (Evidence)
UniGene41075
DFCITC1586290, TC1597652
DoTSDT.60101540
NIA Mouse Gene IndexU008955
Consensus CDS ProjectCCDS22007.1
International Mouse Knockout Project StatusDrd4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025496 Ensembl Gene Model | MGI Sequence Detail 2994 C57BL/6J ±  kb
transcript ENSMUST00000026569 Ensembl | MGI Sequence Detail 1334 Not Applicable 
polypeptide ENSMUSP00000026569 Ensembl | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(1)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002185 Dopamine D4 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001179 D(4) dopamine receptor
References (Earliest) J:22009 Rao PA, et al., Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 1994 Nov;51(11):912-7
(Latest) J:202325 Hwang CK, et al., Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells. J Neurosci. 2013 Sep 18;33(38):14989-97
All references(81)
Other
accession IDs
MGD-MRK-8894, MGD-MRK-8899, MGI:2142209

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory