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Drd4 Gene Detail
Summary
  • Symbol
    Drd4
  • Name
    dopamine receptor D4
  • Synonyms
    D4R, Drd-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:94926
    NCBI Gene: 13491
  • Gene Overview
    MyGene.info: DRD4
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141291974-141296238 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.60 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94926
protein coding gene Chr7:141291974-141296464 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033222
protein coding gene Chr7:146474179-146477172 (+)
A/J MGP_AJ_G0033204
protein coding gene Chr7:142285160-142288153 (+)
AKR/J MGP_AKRJ_G0033136
protein coding gene Chr7:146214296-146217289 (+)
BALB/cJ MGP_BALBcJ_G0033205
protein coding gene Chr7:142030134-142033127 (+)
C3H/HeJ MGP_C3HHeJ_G0032919
protein coding gene Chr7:145972751-145975744 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033716
protein coding gene Chr7:151827196-151830189 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030689
protein coding gene Chr7:143495469-143498492 (+)
CAST/EiJ MGP_CASTEiJ_G0032249
protein coding gene Chr7:138270589-138273597 (+)
CBA/J MGP_CBAJ_G0032891
protein coding gene Chr7:156959426-156962407 (+)
DBA/2J MGP_DBA2J_G0033043
protein coding gene Chr7:140232531-140235512 (+)
FVB/NJ MGP_FVBNJ_G0032996
protein coding gene Chr7:140146196-140149189 (+)
LP/J MGP_LPJ_G0033138
protein coding gene Chr7:147971643-147974634 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033029
protein coding gene Chr7:157619089-157622082 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033736
protein coding gene Chr7:145187483-145190476 (+)
PWK/PhJ MGP_PWKPhJ_G0031953
protein coding gene Chr7:133512573-133515559 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031800
protein coding gene Chr7:132009968-132012978 (+)
WSB/EiJ MGP_WSBEiJ_G0032360
protein coding gene Chr7:146132318-146136904 (+)



Homology
more
  • Human Ortholog
    DRD4, dopamine receptor D4
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DRD4, dopamine receptor D4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D4DR
  • Links
    NCBI Gene ID: 1815
    neXtProt AC: NX_P21917
    UniProt: P21917

  • Chr Location
    11p15.5; chr11:637305-640706 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human DRD4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are less active in open field tests and have reduced responses to novelty. However, mice exhibit locomotor supersensitivity to ethanol, cocaine, and methamphetamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13491 NCBI Gene Model | MGI Sequence Detail 4265 C57BL/6J ±  kb
transcript NM_007878 RefSeq | MGI Sequence Detail 2802 Not Specified  
polypeptide P51436 UniProt | EBI | MGI Sequence Detail 387 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 3
    cDNA 16
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-8894, MGD-MRK-8899, MGI:2142209
References
more
  • Summaries
    All 92
    Developmental Gene Expression 10
    Gene Ontology 13
    Phenotypes 42
  • Earliest
    J:22009 Rao PA, et al., Allelic variation in the D4 dopamine receptor (DRD4) gene does not predict response to clozapine. Arch Gen Psychiatry. 1994 Nov;51(11):912-7
  • Latest
    J:258172 Bonaventura J, et al., Key role of the dopamine D4 receptor in the modulation of corticostriatal glutamatergic neurotransmission. Sci Adv. 2017 Jan;3(1):e1601631

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory