Dpep1 MGI Mouse Gene Detail - MGI:94917

Dpep1 Gene Detail

Symbol

Dpep1
Name

dipeptidase 1 (renal)
Synonyms

MBD

Feature Type

protein coding gene
IDs

MGI:94917
NCBI Gene: 13479
Gene Overview

MyGene.info: DPEP1

Sequence Map

Chr8:123186242-123201812 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

15571 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.08 cM
Mapping Data

3 experiments

Human Ortholog

DPEP1, dipeptidase 1

Vertebrate Orthologs

9

Human Ortholog

DPEP1, dipeptidase 1
Orthology source: HomoloGene, HGNC
Synonyms

MBD1, MDP, RDP
Links

HGNC:3002

NCBI Gene ID: 1800

neXtProt AC: NX_P16444

UniProt: P16444
Chr Location

16q24.3; chr16:89613308-89641540 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 80192
1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DPEP1
Protein SuperFamily

membrane dipeptidase
Gene Tree

Dpep1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
5 phenotype references

All Mutations and Alleles

4
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available

Mice homozygous for disruption of this gene ar phenotypically normal although defects have been noted in the conversion of leukotriene D4 to leukotrience E4.

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All GO Annotations

28
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

105
Tissues

92
cDNA Data

9
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Dpep1 interacts with 107 markers (Mir24-1, Mir24-2, Mir25, ...) View All

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All Sequences

33
RefSeq

4
UniProt

5
CCDS

CCDS22750.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000061883	VEGA Gene Model \| MGI Sequence Detail	15571	C57BL/6J	± kb
transcript	OTTMUST00000151011	VEGA \| MGI Sequence Detail	2236	Not Applicable
polypeptide	OTTMUSP00000078312	VEGA \| MGI Sequence Detail	410	Not Applicable

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SNPs within 2kb

324 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000006646 dipeptidase 1

(term hierarchy)
EC

3.4.13.19
InterPro Domains

IPR028536 Dipeptidase 1

IPR000180 Membrane dipeptidase, active site

IPR032466 Metal-dependent hydrolase

IPR008257 Renal dipeptidase family

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All nucleic 11

cDNA 9

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-8882, MGI:2142515

Summaries

All 34

Developmental Gene Expression 5

Gene Ontology 4

Phenotypes 5
Earliest

J:12584 Satoh S, et al., Purification and molecular cloning of mouse renal dipeptidase. Biochim Biophys Acta. 1993 Jun 4;1163(3):234-42
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/12/2017 MGI 6.10