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Dpep1 Gene Detail
Summary
  • Symbol
    Dpep1
  • Name
    dipeptidase 1
  • Synonyms
    MBD
  • Feature Type
    protein coding gene
  • IDs
    MGI:94917
    NCBI Gene: 13479
  • Gene Overview
    MyGene.info: DPEP1
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123186242-123201812 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    324 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94917
 protein coding gene Chr8:123186235-123201812 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034244
 protein coding gene Chr8:126775016-126794716 (+)
A/J MGP_AJ_G0034224
 protein coding gene Chr8:121524862-121546634 (+)
AKR/J MGP_AKRJ_G0034151
 protein coding gene Chr8:125066088-125079876 (+)
BALB/cJ MGP_BALBcJ_G0034218
 protein coding gene Chr8:121714476-121756331 (+)
C3H/HeJ MGP_C3HHeJ_G0033928
 protein coding gene Chr8:125762328-125778949 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034737
 protein coding gene Chr8:131020980-131039205 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031679
 protein coding gene Chr8:114340611-114360357 (+)
CAST/EiJ MGP_CASTEiJ_G0033256
 protein coding gene Chr8:125837753-125859228 (+)
CBA/J MGP_CBAJ_G0033901
 protein coding gene Chr8:135805376-135843191 (+)
DBA/2J MGP_DBA2J_G0034058
 protein coding gene Chr8:120700860-120723962 (+)
FVB/NJ MGP_FVBNJ_G0034001
 protein coding gene Chr8:119880165-119888969 (+)
LP/J MGP_LPJ_G0034147
 protein coding gene Chr8:126911932-126930554 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034048
 protein coding gene Chr8:137962326-137992905 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034756
 protein coding gene Chr8:125259567-125291126 (+)
PWK/PhJ MGP_PWKPhJ_G0032957
 protein coding gene Chr8:120542518-120557981 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032797
 protein coding gene Chr8:123988452-124004437 (+)
WSB/EiJ MGP_WSBEiJ_G0033372
 protein coding gene Chr8:126006771-126024628 (+)



Homology
more
  • Human Ortholog
    DPEP1, dipeptidase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DPEP1, dipeptidase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MBD1, MDP, RDP
  • Links
    NCBI Gene ID: 1800
    neXtProt AC: NX_P16444
    UniProt: P16444

  • Chr Location
    16q24.3; chr16:89613308-89641540 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for disruption of this gene ar phenotypically normal although defects have been noted in the conversion of leukotriene D4 to leukotrience E4.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    92
  • cDNA Data
    10
  • Literature Summary
    5
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019278 Ensembl Gene Model | MGI Sequence Detail 15571 C57BL/6J ±  kb
transcript ENSMUST00000019422 Ensembl | MGI Sequence Detail 2236 Not Applicable  
polypeptide ENSMUSP00000019422 Ensembl | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-8882, MGI:2142515
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:12584 Satoh S, et al., Purification and molecular cloning of mouse renal dipeptidase. Biochim Biophys Acta. 1993 Jun 4;1163(3):234-42
  • Latest
    J:284980 Choudhury SR, et al., Dipeptidase-1 Is an Adhesion Receptor for Neutrophil Recruitment in Lungs and Liver. Cell. 2019 Aug 22;178(5):1205-1221.e17
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/19/2020
MGI 6.15 		The Jackson Laboratory