Dmp1
Gene Detail

Symbol Name ID

Dmp1 dentin matrix protein 1 MGI:94910

Feature Type

protein coding gene

Genetic Map

Chromosome 5

50.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr5:104202617-104214102 bp, + strand From NCBI annotation of GRCm38   11486 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Dmp1

Human homologs

Human Homolog		DMP1, dentin matrix acidic phosphoprotein 1
NCBI Gene ID		1758
neXtProt AC		NX_Q13316
Human Synonyms		ARHP, ARHR, DMP-1
Human Chr (Location)		4q21; chr4:88571454-88585513 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DMP1

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice do not exhibit an overt phenotype. Skeletal development is largely normal showing only modest increases in the size of the hypertrophic chondrocyte zones and the diameter of long bones.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	biomineral tissue development, extracellular matrix organization, ...
Component	cytoplasm, extracellular region, ...
Function	extracellular matrix binding

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (62)    Tissues (16)    Images (20)
Theiler Stages: 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	46
Northern blot	3
RT-PCR	13

cDNA source data(5)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(12) cDNA(7) Primer pair(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000029307 (Evidence)
Entrez Gene	13406 (Evidence)
UniGene	199008
DFCI	TC1589175, TC1655497
DoTS	DT.101362240
Consensus CDS Project	CCDS19484.1
International Mouse Knockout Project Status	Dmp1

Sequences

Length	Strain/Species
genomic	13406	NCBI Gene Model | MGI Sequence Detail	11486	C57BL/6J
transcript	NM_016779	RefSeq | MGI Sequence Detail	2760	C57BL/6
polypeptide	O55188	UniProt | EBI | MGI Sequence Detail	503	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(76 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009889	Dentin matrix 1
Protein Ontology	PR:000006540	dentin matrix acidic phosphoprotein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:22787 George A, et al., In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. J Histochem Cytochem. 1994 Dec;42(12):1527-31
(Latest) J:189832 Rangiani A, et al., Protective roles of DMP1 in high phosphate homeostasis. PLoS One. 2012;7(8):e42329
All references(65)

Other accession IDs

MGD-MRK-8872, MGI:2141103