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Dmp1
Gene Detail
Symbol

Name
ID
Dmp1
dentin matrix protein 1
MGI:94910
Feature Type
protein coding gene
Genetic Map
Chromosome 5
50.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:104202613-104214102 bp, + strand
From VEGA annotation of GRCm38

  11490 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: DMP1
Gene Tree: Dmp1

Human
homologs
DMP1, dentin matrix acidic phosphoprotein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1758
neXtProt AC: NX_Q13316

Human Synonyms: ARHP, ARHR, DMP-1

Human Chr (Location): 4q21; chr4:87650302-87664361 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DMP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice do not exhibit an overt phenotype. Skeletal development is largely normal showing only modest increases in the size of the hypertrophic chondrocyte zones and the diameter of long bones.
 
Phenotype Images(5)
Interactions
Dmp1 interacts with 127 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process biomineral tissue development, extracellular matrix organization, ...
Component cytoplasm, extracellular region, ...
Function extracellular matrix binding
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (62)    Tissues (17)    Images (20)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
Northern blot 3
RT-PCR 13
cDNA source data(5)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(7) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000053772 (Evidence)
Ensembl Gene Model ENSMUSG00000029307 (Evidence)
Entrez Gene 13406 (Evidence)
UniGene 199008
DFCI TC1589175, TC1655497
DoTS DT.101362240
Consensus CDS Project CCDS19484.1
International Mouse Phenotyping Consortium Status Dmp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053772 VEGA Gene Model | MGI Sequence Detail 11490 C57BL/6J ±  kb
transcript OTTMUST00000133853 VEGA | MGI Sequence Detail 2764 Not Applicable 
polypeptide OTTMUSP00000071084 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009889 Dentin matrix 1
Protein Ontology PR:000006540 dentin matrix acidic phosphoprotein 1
References
(Earliest) J:22787 George A, et al., In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. J Histochem Cytochem. 1994 Dec;42(12):1527-31
(Latest) J:217455 Holm E, et al., Loss of bone sialoprotein leads to impaired endochondral bone development and mineralization. Bone. 2015 Feb;71:145-54
All references(73)
Other
accession IDs
MGD-MRK-8872, MGI:2141103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory