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Dmp1 Gene Detail
Summary
  • Symbol
    Dmp1
  • Name
    dentin matrix protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94910
    NCBI Gene: 13406
  • Gene Overview
    MyGene.info: DMP1
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:104202613-104214102 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94910
protein coding gene Chr5:104197558-104214109 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029811
protein coding gene Chr5:105882227-105893680 (+)
A/J MGP_AJ_G0029775
protein coding gene Chr5:101894493-101906019 (+)
AKR/J MGP_AKRJ_G0029723
protein coding gene Chr5:105185741-105197204 (+)
BALB/cJ MGP_BALBcJ_G0029787
protein coding gene Chr5:102965999-102977529 (+)
C3H/HeJ MGP_C3HHeJ_G0029509
protein coding gene Chr5:105588850-105600545 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030242
protein coding gene Chr5:110211731-110224092 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027477
protein coding gene Chr5:97024751-97036434 (+)
CAST/EiJ MGP_CASTEiJ_G0028921
protein coding gene Chr5:104297373-104316396 (+)
CBA/J MGP_CBAJ_G0029480
protein coding gene Chr5:114041967-114053560 (+)
DBA/2J MGP_DBA2J_G0029624
protein coding gene Chr5:102080688-102097167 (+)
FVB/NJ MGP_FVBNJ_G0029583
protein coding gene Chr5:100866809-100883343 (+)
LP/J MGP_LPJ_G0029712
protein coding gene Chr5:106453453-106465940 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029612
protein coding gene Chr5:118971120-118987548 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030275
protein coding gene Chr5:104717796-104729036 (+)
PWK/PhJ MGP_PWKPhJ_G0028638
protein coding gene Chr5:100533071-100549014 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028474
protein coding gene Chr5:102371240-102382673 (+)
WSB/EiJ MGP_WSBEiJ_G0028999
protein coding gene Chr5:105092014-105105666 (+)



Homology
more
  • Human Ortholog
    DMP1, dentin matrix acidic phosphoprotein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DMP1, dentin matrix acidic phosphoprotein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARHP, ARHR, DMP-1
  • Links
    NCBI Gene ID: 1758
    neXtProt AC: NX_Q13316
    UniProt: Q13316

  • Chr Location
    4q22.1; chr4:87650302-87664361 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dmp1 mouse models; 1 with human DMP1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 2 alleles in 4 genetic backgrounds
    5 images
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hypophosphatemia, rickets, osteomalacia, renal phosphate-wasting, impaired osteocyte maturation, defective dentinogenesis, and severe alveolar bone and cementum defects leading to early periodontal breakdown.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029307 Ensembl Gene Model | MGI Sequence Detail 11490 C57BL/6J ±  kb
    transcript ENSMUST00000066708 Ensembl | MGI Sequence Detail 2764 Not Applicable  
    polypeptide ENSMUSP00000068053 Ensembl | MGI Sequence Detail 503 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 8
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8872, MGI:2141103
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 32
      Diseases 1
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:261043 Chan WL, et al., Impaired proteoglycan glycosylation, elevated TGF-beta signaling, and abnormal osteoblast differentiation as the basis for bone fragility in a mouse model for gerodermia osteodysplastica. PLoS Genet. 2018 Mar;14(3):e1007242

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory