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Dmp1
Gene Detail
 Symbol
Name
ID
Dmp1
dentin matrix protein 1
MGI:94910
Feature Type protein coding gene
Genetic Map
Chromosome 5
50.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:104202617-104214102 bp, + strand
From NCBI annotation of GRCm38

  11486 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Dmp1

Human
homologs
Human Homolog DMP1, dentin matrix acidic phosphoprotein 1
NCBI Gene ID 1758
neXtProt AC  NX_Q13316
Human Synonyms  ARHP, ARHR, DMP-1
Human Chr (Location)  4q21; chr4:87650302-87664361 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DMP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice do not exhibit an overt phenotype. Skeletal development is largely normal showing only modest increases in the size of the hypertrophic chondrocyte zones and the diameter of long bones.
 
Phenotype Images(5)
Interactions
Dmp1 interacts with 127 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process biomineral tissue development, extracellular matrix organization, ...
Component cytoplasm, extracellular region, ...
Function extracellular matrix binding
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (62)    Tissues (16)    Images (20)
Theiler Stages: 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 46
Northern blot 3
RT-PCR 13
cDNA source data(5)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(12) cDNA(7) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000029307 (Evidence)
Entrez Gene13406 (Evidence)
UniGene199008
DFCITC1589175, TC1655497
DoTSDT.101362240
Consensus CDS ProjectCCDS19484.1
International Mouse Knockout Project StatusDmp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13406 NCBI Gene Model | MGI Sequence Detail 11486 C57BL/6J ±  kb
transcript NM_016779 RefSeq | MGI Sequence Detail 2760 C57BL/6 
polypeptide O55188 UniProt | EBI | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(4) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(179 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009889 Dentin matrix 1
Protein Ontology PR:000006540 dentin matrix acidic phosphoprotein 1
Graphical View of Protein Domain Structure
References (Earliest) J:22787 George A, et al., In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. J Histochem Cytochem. 1994 Dec;42(12):1527-31
(Latest) J:201887 Zhu S, et al., Cooperation between Dmp1 Loss and Cyclin D1 Overexpression in Breast Cancer. Am J Pathol. 2013 Oct;183(4):1339-50
All references(68)
Other
accession IDs
MGD-MRK-8872, MGI:2141103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory