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Dmp1 Gene Detail
Summary
  • Symbol
    Dmp1
  • Name
    dentin matrix protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94910
    NCBI Gene: 13406
  • Gene Overview
    MyGene.info: DMP1
Location & Maps
more
  • Sequence Map
    Chr5:104202613-104214102 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11490 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 50.61 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DMP1, dentin matrix acidic phosphoprotein 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DMP1, dentin matrix acidic phosphoprotein 1
    Orthology source: HomoloGene
  • Synonyms
    ARHP, ARHR, DMP-1
  • Links
    NCBI Gene ID: 1758
    neXtProt AC: NX_Q13316

  • Chr Location
    4q21; chr4:87650302-87664361 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dmp1 mouse models; 1 with human DMP1 associations

Human Disease Mouse Models
       Hypophosphatemic Rickets, Autosomal Recessive, 1; ARHR1   OMIM: 241520 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 2 alleles in 4 genetic backgrounds
    5 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Dmp1
  • Incidental Mutations
Homozygous null mice do not exhibit an overt phenotype. Skeletal development is largely normal showing only modest increases in the size of the hypertrophic chondrocyte zones and the diameter of long bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053772 VEGA Gene Model | MGI Sequence Detail 11490 C57BL/6J ±  kb
transcript OTTMUST00000133853 VEGA | MGI Sequence Detail 2764 Not Applicable  
polypeptide OTTMUSP00000071084 VEGA | MGI Sequence Detail 503 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    213 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006540 dentin matrix acidic phosphoprotein 1
  • InterPro Domains
    IPR009889 Dentin matrix 1
Molecular
Reagents
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  • All nucleic 12
    cDNA 7
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-8872, MGI:2141103
References
more
  • Summaries
    All 78
    Developmental Gene Expression 28
    Diseases 1
    Gene Ontology 6
    Phenotypes 30
  • Earliest
    J:22787 George A, et al., In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. J Histochem Cytochem. 1994 Dec;42(12):1527-31
  • Latest
    J:233764 Gullard A, et al., MEPE Localization in the Craniofacial Complex and Function in Tooth Dentin Formation. J Histochem Cytochem. 2016 Apr;64(4):224-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory