Dio1
Gene Detail

Symbol Name ID

Dio1 deiodinase, iodothyronine, type I MGI:94896

Synonyms

D1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

50.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr4:107291465-107307169 bp, - strand From VEGA annotation of GRCm38   15705 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: iodothyronine deiodinase
Gene Tree: Dio1

Human homologs

Human Homolog		DIO1, deiodinase, iodothyronine, type I
NCBI Gene ID		1733
neXtProt AC		NX_P49895
Human Synonyms		5DI, TXDI1
Human Chr (Location)		1p33-p32; chr1:54359861-54376759 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DIO1

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for a disruption in this gene display elevated thyroxine (T4) and reverse triiodothyronine (rT3) levels and changes in the metabolism and excretion of iodothyronines.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	hormone biosynthetic process, oxidation-reduction process
Component	endoplasmic reticulum, integral to membrane, ...
Function	oxidoreductase activity, selenium binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (146)    Tissues (140)    Images (2)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	94
Northern blot	2
RT-PCR	50

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(34) Genomic(3) cDNA(28) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000008706 (Evidence)
Ensembl Gene Model	ENSMUSG00000034785 (Evidence)
Entrez Gene	13370 (Evidence)
UniGene	148342
DFCI	TC1582803
DoTS	DT.103548818, DT.530312
NIA Mouse Gene Index	U025339
EC	1.97.1.10
Consensus CDS Project	CCDS18436.1
International Mouse Knockout Project Status	Dio1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008706	VEGA Gene Model | MGI Sequence Detail	15705	C57BL/6J
transcript	OTTMUST00000019775	VEGA | MGI Sequence Detail	1690	Not Applicable
polypeptide	OTTMUSP00000009059	VEGA | MGI Sequence Detail	257	Not Applicable

All sequences(53) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs(120 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000643	Iodothyronine deiodinase
InterPro	IPR008261	Iodothyronine deiodinase, active site
Protein Ontology	PR:000006480	type I iodothyronine deiodinase

References

(Earliest) J:3643 Schoenmakers CH, et al., Impairment of the selenoenzyme type I iodothyronine deiodinase in C3H/He mice. Endocrinology. 1993 Jan;132(1):357-61
(Latest) J:182286 Charalambous M, et al., Imprinted gene dosage is critical for the transition to independent life. Cell Metab. 2012 Feb 8;15(2):209-21
All references(50)

Other accession IDs

MGD-MRK-8849