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Dio1
Gene Detail
Symbol

Name
ID
Dio1
deiodinase, iodothyronine, type I
MGI:94896
Synonyms
D1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
50.18 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr4:107291465-107307169 bp, - strand
From VEGA annotation of GRCm38

  15705 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:620  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: iodothyronine deiodinase
Gene Tree: Dio1

Human
homologs
Human Homolog DIO1, deiodinase, iodothyronine, type I
NCBI Gene ID 1733
neXtProt AC  NX_P49895
Human Synonyms  5DI, TXDI1
Human Chr (Location)  1p33-p32; chr1:53894188-53911086 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DIO1
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
 
Mice homozygous for a disruption in this gene display elevated thyroxine (T4) and reverse triiodothyronine (rT3) levels and changes in the metabolism and excretion of iodothyronines.
 
Interactions
Dio1 interacts with 134 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process hormone biosynthetic process, oxidation-reduction process
Component endoplasmic reticulum, integral component of membrane, ...
Function oxidoreductase activity, selenium binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (146)    Tissues (140)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 2
RT-PCR 50
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(3) cDNA(28) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008706 (Evidence)
Ensembl Gene ModelENSMUSG00000034785 (Evidence)
Entrez Gene13370 (Evidence)
UniGene148342
DFCITC1582803
DoTSDT.103548818, DT.530312
NIA Mouse Gene IndexU025339
EC1.97.1.10
Consensus CDS ProjectCCDS18436.1
International Mouse Knockout Project StatusDio1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008706 VEGA Gene Model | MGI Sequence Detail 15705 C57BL/6J ±  kb
transcript OTTMUST00000019775 VEGA | MGI Sequence Detail 1690 Not Applicable 
polypeptide OTTMUSP00000009059 VEGA | MGI Sequence Detail 257 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(2) UniProt(11)
Polymorphisms
All PCR and RFLP(6) : PCR(1) RFLP(5) SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000643 Iodothyronine deiodinase
InterPro IPR008261 Iodothyronine deiodinase, active site
InterPro IPR027252 Iodothyronine deiodinase I/III
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000006480 type I iodothyronine deiodinase
References
(Earliest) J:3643 Schoenmakers CH, et al., Impairment of the selenoenzyme type I iodothyronine deiodinase in C3H/He mice. Endocrinology. 1993 Jan;132(1):357-61
(Latest) J:214159 Galton VA, et al., The 5'-deiodinases are not essential for the fasting-induced decrease in circulating thyroid hormone levels in male mice: possible roles for the type 3 deiodinase and tissue sequestration of hormone. Endocrinology. 2014 Aug;155(8):3172-81
All references(53)
Other
accession IDs
MGD-MRK-8849

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory