Cyb5r3
Gene Detail

Symbol Name ID

Cyb5r3 cytochrome b5 reductase 3 MGI:94893

Synonyms

0610016L08Rik, 2500002N19Rik, Dia1, Dia-1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

39.40 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr15:83153494-83172592 bp, - strand From VEGA annotation of GRCm38   19099 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:47921  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: cytochrome-b5 reductase
Gene Tree: Cyb5r3

Human homologs

Human Homolog		CYB5R3, cytochrome b5 reductase 3
NCBI Gene ID		1727
neXtProt AC		NX_P00387
Human Synonyms		B5R, DIA1
Human Chr (Location)		22q13.2; chr22:43013846-43045405 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CYB5R3

Alleles and phenotypes

All alleles(13) : Targeted(1) Gene trapped(12)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cholesterol biosynthetic process, cholesterol metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	ADP binding, AMP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (102)    Tissues (102)    Images (2)
Theiler Stages: 3, 4, 5, 13, 22

Assay Type	Results
RNA in situ	95
RT-PCR	7

cDNA source data(230)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(232) cDNA(230) Primer pair(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000030694 (Evidence)
Ensembl Gene Model	ENSMUSG00000018042 (Evidence)
Entrez Gene	109754 (Evidence)
UniGene	22560
DFCI	TC1573537, TC1592904
NIA Mouse Gene Index	U036468
EC	1.6.2.2
Consensus CDS Project	CCDS27698.1
International Mouse Knockout Project Status	Cyb5r3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030694	VEGA Gene Model | MGI Sequence Detail	19099	C57BL/6J
transcript	OTTMUST00000075995	VEGA | MGI Sequence Detail	2547	Not Applicable
polypeptide	OTTMUSP00000039933	VEGA | MGI Sequence Detail	313	Not Applicable

All sequences(56) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(49 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017927	Ferredoxin reductase-type FAD-binding domain
InterPro	IPR001709	Flavoprotein pyridine nucleotide cytochrome reductase
InterPro	IPR001834	NADH:cytochrome b5 reductase (CBR)
InterPro	IPR008333	Oxidoreductase, FAD-binding domain
InterPro	IPR001433	Oxidoreductase FAD/NAD(P)-binding
InterPro	IPR017938	Riboflavin synthase-like beta-barrel
Protein Ontology	PR:000006082	NADH-cytochrome b5 reductase 3

References

(Earliest) J:6442 Taggart RT, et al., Assignment of the gene for NADH diaphorase Dia-1 to Mouse chromosome 15. Somatic Cell Genet. 1980 Nov;6(6):769-76
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)

Other accession IDs

MGD-MRK-8844, MGD-MRK-8846, MGI:1919569, MGI:1924141, MGI:2146303