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Cyb5r3
Gene Detail
 Symbol
Name
ID
Cyb5r3
cytochrome b5 reductase 3
MGI:94893
Synonyms 0610016L08Rik, 2500002N19Rik, Dia1, Dia-1
Feature Type protein coding gene
Genetic Map
Chromosome 15
39.40 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr15:83153494-83172592 bp, - strand
From VEGA annotation of GRCm38

  19099 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:47921  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: cytochrome-b5 reductase
Gene Tree: Cyb5r3

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Radiation induced(1) Targeted(1)
Genomic Mutations involving Cyb5r3 (1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Cyb5r3 interacts with 167 markers (Mir15b, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cholesterol biosynthetic process, cholesterol metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function ADP binding, AMP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (98)    Tissues (98)    Images (2)
Theiler Stages: 3, 4, 13, 22
Assay TypeResults
RNA in situ 95
RT-PCR 3
cDNA source data(236)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(238) cDNA(236) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000030694 (Evidence)
Ensembl Gene ModelENSMUSG00000018042 (Evidence)
Entrez Gene109754 (Evidence)
UniGene22560
DFCITC1573537, TC1592904
NIA Mouse Gene IndexU036468
EC1.6.2.2
Consensus CDS ProjectCCDS27698.1
International Mouse Knockout Project StatusCyb5r3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030694 VEGA Gene Model | MGI Sequence Detail 19099 C57BL/6J ±  kb
transcript OTTMUST00000075995 VEGA | MGI Sequence Detail 2547 Not Applicable 
polypeptide OTTMUSP00000039933 VEGA | MGI Sequence Detail 313 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017927 Ferredoxin reductase-type FAD-binding domain
InterPro IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
InterPro IPR001834 NADH:cytochrome b5 reductase (CBR)
InterPro IPR008333 Oxidoreductase, FAD-binding domain
InterPro IPR001433 Oxidoreductase FAD/NAD(P)-binding
InterPro IPR017938 Riboflavin synthase-like beta-barrel
Protein Ontology PR:000006082 NADH-cytochrome b5 reductase 3
References (Earliest) J:6442 Taggart RT, et al., Assignment of the gene for NADH diaphorase Dia-1 to Mouse chromosome 15. Somatic Cell Genet. 1980 Nov;6(6):769-76
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(48)
Other
accession IDs
MGD-MRK-8844, MGD-MRK-8846, MGI:1919569, MGI:1924141, MGI:2146303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory