About   Help   FAQ
Eci1
Gene Detail
 Symbol
Name
ID
Eci1
enoyl-Coenzyme A delta isomerase 1
MGI:94871
Synonyms Dci, eci
Feature Type protein coding gene
Genetic Map
Chromosome 17
12.39 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:24426683-24439316 bp, + strand
From NCBI annotation of GRCm38

  12634 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37554  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 4-chlorobenzoate-CoA dehalogenase 30K chain
Gene Tree: Eci1

Human
homologs
Human Homolog ECI1, enoyl-CoA delta isomerase 1
NCBI Gene ID 1632
neXtProt AC  NX_P42126
Human Synonyms  DCI
Human Chr (Location)  16p13.3; chr16:2239872-2251601 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(10) Targeted(1)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for disruption of this gene are normal until stressed. Starvation results in increased accumulation of triglycerides and unsaturated fatty acids in the liver and kidney. Secretion of fatty acid metabolites in the urine is greatly increased.
 
Interactions
Eci1 interacts with 34 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process fatty acid beta-oxidation, fatty acid metabolic process, ...
Component extracellular vesicular exosome, mitochondrial inner membrane, ...
Function catalytic activity, dodecenoyl-CoA delta-isomerase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) Genomic(2) cDNA(83) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024132 (Evidence)
Entrez Gene13177 (Evidence)
UniGene291743
DFCITC1578354
DoTSDT.60118844
NIA Mouse Gene IndexU017635
EC5.3.3.8
Consensus CDS ProjectCCDS28480.1
International Mouse Knockout Project StatusEci1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13177 NCBI Gene Model | MGI Sequence Detail 12634 C57BL/6J ±  kb
transcript NM_010023 RefSeq | MGI Sequence Detail 1091 Not Specified 
polypeptide P42125 UniProt | EBI | MGI Sequence Detail 289 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(172 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001753 Crotonase superfamily
InterPro IPR018376 Enoyl-CoA hydratase/isomerase, conserved site
Protein Ontology PR:000006308 enoyl-CoA delta isomerase 1, mitochondrial
Graphical View of Protein Domain Structure
References (Earliest) J:15191 Stoffel W, et al., Molecular cloning and gene organization of the mouse mitochondrial 3,2-trans-enoyl-CoA isomerase. FEBS Lett. 1993 Oct 25;333(1-2):119-22
(Latest) J:192394 van Weeghel M, et al., Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsaturated fatty acids. FASEB J. 2012 Oct;26(10):4316-26
All references(38)
Other
accession IDs
MGD-MRK-8810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory