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Dbx1
Gene Detail
Symbol

Name
ID
Dbx1
developing brain homeobox 1
MGI:94867
Synonyms
Dbx, Mmox C
Feature Type
protein coding gene
Genetic Map
Chromosome 7
31.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:49631499-49636849 bp, - strand
From VEGA annotation of GRCm38

  5351 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:19002  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DBX1
Gene Tree: Dbx1

Human
homologs
DBX1, developing brain homeobox 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 120237
neXtProt AC: NX_A6NMT0

Human Chr (Location): 11p15.1; chr11:20156214-20160324 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene die at birth. V0 interneurons develop as V1 or dl6 interneurons.
 
Interactions
Dbx1 interacts with 165 markers (Mir1b, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process multicellular organismal development, regulation of transcription, DNA-templated, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding
External Resources: FuncBase
Expression
Literature Summary: (108 records)
Data Summary: Results (289)    Tissues (140)    Images (79)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 279
Northern blot 1
RT-PCR 4
RNase protection 5
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dbx1 ; ZFIN dbx1a, dbx1b    NEW 
Molecular
reagents
All nucleic(27) Genomic(5) cDNA(13) Primer pair(2) Other(7)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037230 (Evidence)
Ensembl Gene Model ENSMUSG00000030507 (Evidence)
Entrez Gene 13172 (Evidence)
UniGene 307176
DFCI TC1588401
DoTS DT.40152104
NIA Mouse Gene Index U028599
Consensus CDS Project CCDS21306.1
International Mouse Phenotyping Consortium Status Dbx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037230 VEGA Gene Model | MGI Sequence Detail 5351 C57BL/6J ±  kb
transcript OTTMUST00000096003 VEGA | MGI Sequence Detail 2091 Not Applicable 
polypeptide OTTMUSP00000053593 VEGA | MGI Sequence Detail 335 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000006301 homeobox protein DBX1
References
(Earliest) J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
(Latest) J:221657 Kong JH, et al., Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26;33(4):373-87
All references(150)
Other
accession IDs
MGD-MRK-8806, MGI:2141937

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory