Dbp MGI Mouse Gene Detail - MGI:94866 - D site albumin promoter binding protein

Symbol

Dbp
Name

D site albumin promoter binding protein

Feature Type

protein coding gene
IDs

MGI:94866
NCBI Gene: 13170
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr7:45354518-45359627 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.45 cM
Mapping Data

3 experiments

SNPs within 2kb

41 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94866	protein coding gene	Chr7:45354512-45359627 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032241	protein coding gene	Chr7:46013651-46018716 (+)
A/J	MGP_AJ_G0032220	protein coding gene	Chr7:45101058-45106125 (+)
AKR/J	MGP_AKRJ_G0032156	protein coding gene	Chr7:46353155-46358222 (+)
BALB/cJ	MGP_BALBcJ_G0032232	protein coding gene	Chr7:45095806-45100873 (+)
C3H/HeJ	MGP_C3HHeJ_G0031947	protein coding gene	Chr7:46847412-46852477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032724	protein coding gene	Chr7:48264267-48269334 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029738	protein coding gene	Chr7:47655094-47660188 (+)
CAST/EiJ	MGP_CASTEiJ_G0031276	protein coding gene	Chr7:38287674-38292740 (+)
CBA/J	MGP_CBAJ_G0031912	protein coding gene	Chr7:49874022-49879089 (+)
DBA/2J	MGP_DBA2J_G0032070	protein coding gene	Chr7:44781682-44786747 (+)
FVB/NJ	MGP_FVBNJ_G0032021	protein coding gene	Chr7:44554368-44559435 (+)
LP/J	MGP_LPJ_G0032148	protein coding gene	Chr7:46718314-46723381 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032058	protein coding gene	Chr7:48554992-48560059 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032740	protein coding gene	Chr7:45564382-45569450 (+)
PWK/PhJ	MGP_PWKPhJ_G0030998	protein coding gene	Chr7:38148596-38153660 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030836	protein coding gene	Chr7:33595165-33600230 (+)
WSB/EiJ	MGP_WSBEiJ_G0031393	protein coding gene	Chr7:46068666-46073733 (+)

Human Ortholog

DBP, D-box binding PAR bZIP transcription factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DBP, D-box binding PAR bZIP transcription factor
Synonyms

DABP, taxREB302
Links

HGNC:2697

NCBI Gene ID: 1628

neXtProt AC: NX_Q10586

UniProt: Q10586
Chr Location

19q13.33; chr19:48630560-48637550 (-) GRCh38.p7

Alliance of Genome Resources

Dbp stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DBP
Gene Tree

Dbp

Diseases

1 with human DBP associations

				Human Disease	Mouse Models
				osteoporosis IDs osteoporosis DOID:11476 EFO:0003882 ICD10CM:M81.0 ICD9CM:733.0 ICD9CM:733.00 MESH:D010024 NCI:C3298 OMIM:166710 UMLS_CUI:C0029456

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
16 phenotypes from multigenic genotypes
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

3
Gene trapped

12
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

15 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a null mutation display a shortened circadian period and decreased acvtivity during the dark phase.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

948
Tissues

128
cDNA Data

9
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dbp

ZFIN dbpa, dbpb

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Dbp interacts with 34 markers (Mir20a, Mir22, Mir23a, ...) View All

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All Sequences

57
RefSeq

8
UniProt

5
CCDS

CCDS21260.1

Ensembl

ENSMUSG00000059824 (Evidence)
NCBI Gene

13170

			Length	Strain/Species	Flank
genomic	13170	NCBI Gene Model \| MGI Sequence Detail	5110	C57BL/6J	± kb
transcript	NM_016974	RefSeq \| MGI Sequence Detail	1643	C57BL/6
polypeptide	Q60925	UniProt \| EBI \| MGI Sequence Detail	325	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006298 D site-binding protein

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR029830 D site-binding protein

IPR040223 PAR basic leucine zipper protein

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All nucleic 15

Genomic 2

cDNA 10

Primer pair 2

Other 1

Microarray probesets 4

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MGD-MRK-8803

Summaries

All 80

Developmental Gene Expression 14

Gene Ontology 6

Phenotypes 22
Earliest

J:81277 Drolet DW, et al., TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 1991 Oct;5(10):1739-53
Latest

J:317802 Smith CB, et al., Cell-Type-Specific Circadian Bioluminescence Rhythms in Dbp Reporter Mice. J Biol Rhythms. 2022 Jan 13;:7487304211069452

TSS for Dbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66612	Chr7:45354609-45354716 (+)	145 bp
Tssr66613	Chr7:45354717-45354731 (+)	206 bp
Tssr66614	Chr7:45354754-45354773 (+)	246 bp
Tssr66615	Chr7:45354784-45354816 (+)	282 bp
Tssr66616	Chr7:45354834-45354847 (+)	323 bp
Tssr66617	Chr7:45354868-45354877 (+)	355 bp
Tssr66618	Chr7:45354942-45354956 (+)	431 bp
Tssr66619	Chr7:45355615-45355644 (+)	1,112 bp
Tssr66620	Chr7:45355654-45355672 (+)	1,145 bp
Tssr66621	Chr7:45356552-45356566 (+)	2,041 bp
Tssr66622	Chr7:45357236-45357253 (+)	2,727 bp
Tssr66623	Chr7:45357323-45357359 (+)	2,823 bp
Tssr66624	Chr7:45357575-45357616 (+)	3,078 bp
Tssr66625	Chr7:45357619-45357643 (+)	3,113 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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