Dbp MGI Mouse Gene Detail - MGI:94866 - D site albumin promoter binding protein

Symbol

Dbp
Name

D site albumin promoter binding protein

Feature Type

protein coding gene
IDs

MGI:94866
NCBI Gene: 13170
Gene Overview

MyGene.info: DBP
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:45705093-45710203 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.45 cM
Mapping Data

3 experiments

SNPs within 2kb

41 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_94866	protein coding gene	Chr7:45705088-45710203 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032241	protein coding gene	Chr7:46013651-46018716 (+)
A/J	MGP_AJ_G0032220	protein coding gene	Chr7:45101058-45106125 (+)
AKR/J	MGP_AKRJ_G0032156	protein coding gene	Chr7:46353155-46358222 (+)
BALB/cJ	MGP_BALBcJ_G0032232	protein coding gene	Chr7:45095806-45100873 (+)
C3H/HeJ	MGP_C3HHeJ_G0031947	protein coding gene	Chr7:46847412-46852477 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032724	protein coding gene	Chr7:48264267-48269334 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029738	protein coding gene	Chr7:47655094-47660188 (+)
CAST/EiJ	MGP_CASTEiJ_G0031276	protein coding gene	Chr7:38287674-38292740 (+)
CBA/J	MGP_CBAJ_G0031912	protein coding gene	Chr7:49874022-49879089 (+)
DBA/2J	MGP_DBA2J_G0032070	protein coding gene	Chr7:44781682-44786747 (+)
FVB/NJ	MGP_FVBNJ_G0032021	protein coding gene	Chr7:44554368-44559435 (+)
LP/J	MGP_LPJ_G0032148	protein coding gene	Chr7:46718314-46723381 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032058	protein coding gene	Chr7:48554992-48560059 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032740	protein coding gene	Chr7:45564382-45569450 (+)
PWK/PhJ	MGP_PWKPhJ_G0030998	protein coding gene	Chr7:38148596-38153660 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030836	protein coding gene	Chr7:33595165-33600230 (+)
WSB/EiJ	MGP_WSBEiJ_G0031393	protein coding gene	Chr7:46068666-46073733 (+)

Human Ortholog

DBP, D-box binding PAR bZIP transcription factor

Vertebrate Orthologs

8

Human Ortholog

DBP, D-box binding PAR bZIP transcription factor
Orthology source: HomoloGene, HGNC
Synonyms

DABP, taxREB302
Links

HGNC:2697

NCBI Gene ID: 1628

neXtProt AC: NX_Q10586

UniProt: Q10586
Chr Location

19q13.33; chr19:48630560-48637550 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1035
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DBP
Gene Tree

Dbp

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
16 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

12
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Recombinase Activity

1

Mice homozygous for a null mutation display a shortened circadian period and decreased acvtivity during the dark phase.

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All GO Annotations

14
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

236
Tissues

128
cDNA Data

9
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dbp

ZFIN dbpa, dbpb

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Dbp interacts with 34 markers (Mir20a, Mir22, Mir23a, ...) View All

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All Sequences

55
RefSeq

6
UniProt

5
CCDS

CCDS21260.1

Ensembl

ENSMUSG00000059824 (Evidence)
NCBI Gene

13170

			Length	Strain/Species	Flank
genomic	13170	NCBI Gene Model \| MGI Sequence Detail	5111	C57BL/6J	± kb
transcript	NM_016974	RefSeq \| MGI Sequence Detail	1678	C57BL/6
polypeptide	Q60925	UniProt \| EBI \| MGI Sequence Detail	325	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006298 D site-binding protein

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR029830 D site-binding protein

IPR040223 PAR basic leucine zipper protein

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All nucleic 14

Genomic 2

cDNA 10

Primer pair 1

Other 1

Microarray probesets 4

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MGD-MRK-8803

Summaries

All 70

Developmental Gene Expression 12

Gene Ontology 7

Phenotypes 16
Earliest

J:81277 Drolet DW, et al., TEF, a transcription factor expressed specifically in the anterior pituitary during embryogenesis, defines a new class of leucine zipper proteins. Genes Dev. 1991 Oct;5(10):1739-53
Latest

J:253233 Li P, et al., Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron. 2017 Oct 11;96(2):387-401.e6

TSS for Dbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66612	Chr7:45705185-45705292 (+)	146 bp
Tssr66613	Chr7:45705293-45705307 (+)	207 bp
Tssr66614	Chr7:45705330-45705349 (+)	247 bp
Tssr66615	Chr7:45705360-45705392 (+)	283 bp
Tssr66616	Chr7:45705410-45705423 (+)	324 bp
Tssr66617	Chr7:45705444-45705453 (+)	356 bp
Tssr66618	Chr7:45705518-45705532 (+)	432 bp
Tssr66621	Chr7:45707128-45707142 (+)	2,042 bp
Tssr66623	Chr7:45707899-45707935 (+)	2,824 bp
Tssr66624	Chr7:45708151-45708192 (+)	3,079 bp
Tssr66625	Chr7:45708195-45708219 (+)	3,114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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