Dbp MGI Mouse Gene Detail - MGI:94866 - D site albumin promoter binding protein

Dbp Gene Detail

Symbol

Dbp
Name

D site albumin promoter binding protein

Feature Type

protein coding gene
IDs

MGI:94866
NCBI Gene: 13170
Gene Overview

MyGene.info: DBP

Sequence Map

Chr7:45705088-45710203 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

5116 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.45 cM
Mapping Data

3 experiments

Human Ortholog

DBP, D-box binding PAR bZIP transcription factor

Vertebrate Orthologs

8

Human Ortholog

DBP, D-box binding PAR bZIP transcription factor
Orthology source: HomoloGene, HGNC
Synonyms

DABP
Links

HGNC:2697

NCBI Gene ID: 1628

neXtProt AC: NX_Q10586

UniProt: Q10586
Chr Location

19q13.33; chr19:48630560-48637550 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 1035
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DBP
Gene Tree

Dbp

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotypes from multigenic genotypes
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

12
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available

Mice homozygous for a null mutation display a shortened circadian period and decreased acvtivity during the dark phase.

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All GO Annotations

17
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

229
Tissues

123
cDNA Data

8
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

ZFIN dbpa, dbpb

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Dbp interacts with 34 markers (Mir20a, Mir22, Mir23a, ...) View All

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All Sequences

46
RefSeq

6
UniProt

5
CCDS

CCDS21260.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023187	VEGA Gene Model \| MGI Sequence Detail	5116	C57BL/6J	± kb
transcript	OTTMUST00000056095	VEGA \| MGI Sequence Detail	1837	Not Applicable
polypeptide	OTTMUSP00000026915	VEGA \| MGI Sequence Detail	325	Not Applicable

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SNPs within 2kb

41 from dbSNP Build 142

RFLP

1

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UniProt

5 Sequences
Protein Ontology

PR:000006298 D site-binding protein

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR029830 D site-binding protein

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All nucleic 12

Genomic 2

cDNA 9

Primer pair 1

Microarray probesets 4

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MGD-MRK-8803

Summaries

All 57

Developmental Gene Expression 8

Gene Ontology 6

Phenotypes 16
Earliest

J:909 Szpirer C, et al., Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). Genomics. 1992 Jun;13(2):293-300
Latest

J:240478 Tsuneki H, et al., Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice. Endocrinology. 2016 Nov;157(11):4146-4157

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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