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Dbi
Gene Detail
Symbol

Name
ID
Dbi
diazepam binding inhibitor
MGI:94865
Synonyms
Acbp, diazepam-binding inhibitor, endozepine, EP
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.65 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:120113280-120121078 bp, - strand
From VEGA annotation of GRCm38

  7799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

HCOP human homology predictions: DBI
Protein SuperFamily: endozepine
Gene Tree: Dbi

Human
homologs
DBI, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1622
neXtProt AC: NX_P07108

Human Synonyms: ACBD1, ACBP, CCK-RP, EP

Human Chr (Location): 2q12-q21; chr2:119366924-119372551 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(8) Spontaneous(1) Targeted(6)
Genomic Mutations involving Dbi (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal fur and skin morphology at P16 and impaired metabolic changes at weaning with reduced growth and hepatic cholesterol synthesis. Mice homozygous for a different knock-out allele complete exhibit embryonic lethality around implantation.
 
Interactions
Dbi interacts with 2 markers (Mir7-1, Mir495)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process behavioral fear response, glial cell proliferation, ...
Component contractile fiber, cytoplasm, ...
Function benzodiazepine receptor binding, fatty-acyl-CoA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (10)    Tissues (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(432)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase dbi    NEW 
Molecular
reagents
All nucleic(435) Genomic(1) cDNA(432) Primer pair(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000021601 (Evidence)
Ensembl Gene Model ENSMUSG00000026385 (Evidence)
Entrez Gene 13167 (Evidence)
UniGene 2785
DFCI TC1573116, TC1592694, TC1648619
DoTS DT.101374369, DT.537709, DT.94162443, DT.94162952, DT.99869449
NIA Mouse Gene Index U021703
Consensus CDS Project CCDS15230.1, CCDS15231.1
International Mouse Phenotyping Consortium Status Dbi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021601 VEGA Gene Model | MGI Sequence Detail 7799 C57BL/6J ±  kb
transcript OTTMUST00000051290 VEGA | MGI Sequence Detail 491 Not Applicable 
polypeptide OTTMUSP00000024100 VEGA | MGI Sequence Detail 135 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(6)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
InterPro IPR022408 Acyl-CoA-binding protein, ACBP, conserved site
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
Protein Ontology PR:000006295 acyl-CoA-binding protein
References
(Earliest) J:10271 Owens GP, et al., Sequence and expression of the murine diazepam binding inhibitor. Brain Res Mol Brain Res. 1989 Nov;6(2-3):101-8
(Latest) J:221168 Bouyakdan K, et al., A novel role for central ACBP/DBI as a regulator of long-chain fatty acid metabolism in astrocytes. J Neurochem. 2015 Apr;133(2):253-65
All references(58)
Other
accession IDs
MGD-MRK-36403, MGD-MRK-8802, MGI:107826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory