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Dbi
Gene Detail
Symbol

Name
ID
Dbi
diazepam binding inhibitor
MGI:94865
Synonyms
Acbp, diazepam-binding inhibitor, endozepine, EP
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.65 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:120113280-120121078 bp, - strand
From VEGA annotation of GRCm38

  7799 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: endozepine
Gene Tree: Dbi

Human
homologs
Human Homolog DBI, diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
NCBI Gene ID 1622
neXtProt AC  NX_P07108
Human Synonyms  ACBD1, ACBP, CCK-RP, EP
Human Chr (Location)  2q12-q21; chr2:119366924-119372551 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit abnormal fur and skin morphology at P16 and impaired metabolic changes at weaning with reduced growth and hepatic cholesterol synthesis. Mice homozygous for a different knock-out allele complete exhibit embryonic lethality around implantation.
 
Interactions
Dbi interacts with 2 markers (Mir7-1, Mir495)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process behavioral fear response, glial cell proliferation, ...
Component contractile fiber, cytoplasm, ...
Function benzodiazepine receptor binding, fatty-acyl-CoA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
cDNA source data(432)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(433) Genomic(1) cDNA(432)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000021601 (Evidence)
Ensembl Gene ModelENSMUSG00000026385 (Evidence)
Entrez Gene13167 (Evidence)
UniGene2785
DFCITC1573116, TC1592694, TC1648619
DoTSDT.101374369, DT.537709, DT.94162443, DT.94162952, DT.99869449
NIA Mouse Gene IndexU021703
Consensus CDS ProjectCCDS15230.1, CCDS15231.1
International Mouse Knockout Project StatusDbi
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021601 VEGA Gene Model | MGI Sequence Detail 7799 C57BL/6J ±  kb
transcript OTTMUST00000051290 VEGA | MGI Sequence Detail 491 Not Applicable 
polypeptide OTTMUSP00000024100 VEGA | MGI Sequence Detail 135 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(4) UniProt(11)
Polymorphisms
SNPs within 2kb(92 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000582 Acyl-CoA-binding protein, ACBP
InterPro IPR022408 Acyl-CoA-binding protein, ACBP, conserved site
InterPro IPR014352 FERM/acyl-CoA-binding protein, 3-helical bundle
Protein Ontology PR:000006295 acyl-CoA-binding protein
References
(Earliest) J:10271 Owens GP, et al., Sequence and expression of the murine diazepam binding inhibitor. Brain Res Mol Brain Res. 1989 Nov;6(2-3):101-8
(Latest) J:210222 Hupe M, et al., Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res. 2014 Jan;42(2):e14
All references(57)
Other
accession IDs
MGD-MRK-36403, MGD-MRK-8802, MGI:107826

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory