About   Help   FAQ
Dbh
Gene Detail
Symbol

Name
ID
Dbh
dopamine beta hydroxylase
MGI:94864
Feature Type
protein coding gene
Genetic Map
Chromosome 2
19.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr2:27165233-27183200 bp, + strand
From VEGA annotation of GRCm38

  17968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DBH
Protein SuperFamily: dopamine beta-monooxygenase
Gene Tree: Dbh

Human
homologs
DBH, dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1621
neXtProt AC: NX_P09172

Human Synonyms: DBM

Human Chr (Location): 9q34; chr9:133636363-133659344 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DBH

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygous mutants are embryonic lethal probably due to cardiovascular failure, but survive if treated to replace their dopamine deficit.
 
Human Diseases Modeled in Mice Using Dbh (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Dbh interacts with 52 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process associative learning, behavioral response to ethanol, ...
Component apical part of cell, axon, ...
Function catalytic activity, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (150)    Tissues (117)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 128
RT-PCR 22
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DBH ZFIN dbh    NEW 
Molecular
reagents
All nucleic(28) Genomic(7) cDNA(14) Primer pair(4) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000011838 (Evidence)
Ensembl Gene Model ENSMUSG00000000889 (Evidence)
Entrez Gene 13166 (Evidence)
UniGene 167781
DFCI TC1588189, TC1646085
DoTS DT.94231188, DT.94284876
NIA Mouse Gene Index U001533
EC 1.14.17.1
Consensus CDS Project CCDS38088.1
International Mouse Phenotyping Consortium Status Dbh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011838 VEGA Gene Model | MGI Sequence Detail 17968 C57BL/6J ±  kb
transcript OTTMUST00000027810 VEGA | MGI Sequence Detail 2552 Not Applicable 
polypeptide OTTMUSP00000012634 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(3) : SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
InterPro IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
InterPro IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
InterPro IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
InterPro IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
InterPro IPR005018 DOMON domain
InterPro IPR000945 Dopamine beta-hydroxylase-related
InterPro IPR008977 PHM/PNGase F domain
InterPro IPR028460 Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
Protein Ontology PR:000006294 dopamine beta-hydroxylase
References
(Earliest) J:331 Pilz A, et al., Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992 Apr;12(4):715-9
(Latest) J:221159 Stubbusch J, et al., Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance. Dev Biol. 2015 Apr 15;400(2):210-23
All references(178)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-8801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory