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Dbh Gene Detail
Summary
  • Symbol
    Dbh
  • Name
    dopamine beta hydroxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94864
    NCBI Gene: 13166
  • Gene Overview
    MyGene.info: DBH
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:27165507-27183204 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 19.29 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94864
protein coding gene Chr2:27165233-27183204 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025511
protein coding gene Chr2:25138131-25158943 (+)
A/J MGP_AJ_G0025488
protein coding gene Chr2:24190035-24209107 (+)
AKR/J MGP_AKRJ_G0025458
protein coding gene Chr2:24983482-25003611 (+)
BALB/cJ MGP_BALBcJ_G0025484
protein coding gene Chr2:24308908-24327398 (+)
C3H/HeJ MGP_C3HHeJ_G0025245
protein coding gene Chr2:24918989-24937637 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025928
protein coding gene Chr2:25990076-26009731 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023339
protein coding gene Chr2:23024108-23042255 (+)
CAST/EiJ MGP_CASTEiJ_G0024708
protein coding gene Chr2:24800398-24818302 (+)
CBA/J MGP_CBAJ_G0025223
protein coding gene Chr2:26895094-26915211 (+)
DBA/2J MGP_DBA2J_G0025356
protein coding gene Chr2:24011996-24030577 (+)
FVB/NJ MGP_FVBNJ_G0025318
protein coding gene Chr2:23769392-23787650 (+)
LP/J MGP_LPJ_G0025442
protein coding gene Chr2:25082457-25100072 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025349
protein coding gene Chr2:26932510-26952412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025987
protein coding gene Chr2:24919431-24937326 (+)
PWK/PhJ MGP_PWKPhJ_G0024456
protein coding gene Chr2:23800963-23821307 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024256
protein coding gene Chr2:25062669-25081062 (+)
WSB/EiJ MGP_WSBEiJ_G0024777
protein coding gene Chr2:25034470-25053680 (+)



Homology
more
  • Human Ortholog
    DBH, dopamine beta-hydroxylase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DBH, dopamine beta-hydroxylase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBM
  • Links
    NCBI Gene ID: 1621
    neXtProt AC: NX_P09172
    UniProt: P09172

  • Chr Location
    9q34.2; chr9:133636363-133659344 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dbh mouse models; 1 with human DBH associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    37 phenotypes from multigenic genotypes
    91 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are embryonic lethal probably due to cardiovascular failure, but survive if treated to replace their dopamine deficit.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13166 NCBI Gene Model | MGI Sequence Detail 17698 C57BL/6J ±  kb
    transcript NM_138942 RefSeq | MGI Sequence Detail 2282 C57BL/6  
    polypeptide Q64237 UniProt | EBI | MGI Sequence Detail 622 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006294 dopamine beta-hydroxylase
    • EC
    • InterPro Domains
      IPR024548 Copper type II ascorbate-dependent monooxygenase, C-terminal
      IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
      IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
      IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
      IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
      IPR036939 Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily
      IPR005018 DOMON domain
      IPR008977 PHM/PNGase F domain superfamily
      IPR028460 Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 7
      cDNA 15
      Primer pair 4
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8801
    References
    more
    • Summaries
      All 198
      Developmental Gene Expression 66
      Diseases 1
      Gene Ontology 21
      Phenotypes 91
    • Earliest
      J:331 Pilz A, et al., Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992 Apr;12(4):715-9
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory