Dbh
Gene Detail

Symbol Name ID

Dbh dopamine beta hydroxylase MGI:94864

Feature Type

protein coding gene

Genetic Map

Chromosome 2

19.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr2:27165233-27183200 bp, + strand From VEGA annotation of GRCm38   17968 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: dopamine beta-monooxygenase
Gene Tree: Dbh

Human homologs

Human Homolog		DBH, dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NCBI Gene ID		1621
neXtProt AC		NX_P09172
Human Synonyms		DBM
Human Chr (Location)		9q34; chr9:136501485-136524466 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DBH

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mutants are embryonic lethal probably due to cardiovascular failure, but survive if treated to replace their dopamine deficit.

 
Human Diseases Modeled Using Mouse Dbh (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	associative learning, behavioral response to ethanol, ...
Component	apical part of cell, axon, ...
Function	catalytic activity, copper ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (52 records)
Data Summary: Results (119)    Tissues (100)    Images (6)
Theiler Stages: 13, 15, 17, 19, 22, 28

Assay Type	Results
RNA in situ	97
RT-PCR	22

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(7) cDNA(13) Primer pair(4) Other(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000011838 (Evidence)
Ensembl Gene Model	ENSMUSG00000000889 (Evidence)
Entrez Gene	13166 (Evidence)
UniGene	167781
DFCI	TC1588189, TC1646085
DoTS	DT.94231188, DT.94284876
NIA Mouse Gene Index	U001533
EC	1.14.17.1
Consensus CDS Project	CCDS38088.1
International Mouse Knockout Project Status	Dbh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011838	VEGA Gene Model | MGI Sequence Detail	17968	C57BL/6J
transcript	OTTMUST00000027810	VEGA | MGI Sequence Detail	2552	Not Applicable
polypeptide	OTTMUSP00000012634	VEGA | MGI Sequence Detail	622	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(3) : SNPs(118 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020611	Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
InterPro	IPR014783	Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
InterPro	IPR014784	Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
InterPro	IPR000323	Copper type II, ascorbate-dependent monooxygenase, N-terminal
InterPro	IPR005018	DOMON domain
InterPro	IPR000945	Dopamine-beta-monooxygenase
InterPro	IPR008977	PHM/PNGase F domain
Protein Ontology	PR:000006294	dopamine beta-hydroxylase

References

(Earliest) J:331 Pilz A, et al., Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992 Apr;12(4):715-9
(Latest) J:190746 Osuala K, et al., Physiological and genomic consequences of adrenergic deficiency during embryonic/fetal development in mice: impact on retinoic acid metabolism. Physiol Genomics. 2012 Oct 2;44(19):934-47
All references(164)

Other accession IDs

MGD-MRK-8801