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Dbh
Gene Detail
 Symbol
Name
ID
Dbh
dopamine beta hydroxylase
MGI:94864
Feature Type protein coding gene
Genetic Map
Chromosome 2
19.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr2:27165233-27183200 bp, + strand
From VEGA annotation of GRCm38

  17968 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dopamine beta-monooxygenase
Gene Tree: Dbh

Human
homologs
Human Homolog DBH, dopamine beta-hydroxylase (dopamine beta-monooxygenase)
NCBI Gene ID 1621
neXtProt AC  NX_P09172
Human Synonyms  DBM
Human Chr (Location)  9q34; chr9:133636363-133659344 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human DBH
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygous mutants are embryonic lethal probably due to cardiovascular failure, but survive if treated to replace their dopamine deficit.
 
Human Diseases Modeled Using Mouse Dbh (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Dbh interacts with 52 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process associative learning, behavioral response to ethanol, ...
Component apical part of cell, axon, ...
Function catalytic activity, copper ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (58 records)
Data Summary: Results (130)    Tissues (106)    Images (18)
Theiler Stages: 13, 15, 17, 19, 20, 22, 25, 27
Assay TypeResults
RNA in situ 108
RT-PCR 22
cDNA source data(13)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(7) cDNA(14) Primer pair(4) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000011838 (Evidence)
Ensembl Gene ModelENSMUSG00000000889 (Evidence)
Entrez Gene13166 (Evidence)
UniGene167781
DFCITC1588189, TC1646085
DoTSDT.94231188, DT.94284876
NIA Mouse Gene IndexU001533
EC1.14.17.1
Consensus CDS ProjectCCDS38088.1
International Mouse Knockout Project StatusDbh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011838 VEGA Gene Model | MGI Sequence Detail 17968 C57BL/6J ±  kb
transcript OTTMUST00000027810 VEGA | MGI Sequence Detail 2552 Not Applicable 
polypeptide OTTMUSP00000012634 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms RFLP(3) : SNPs within 2kb(192 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020611 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
InterPro IPR014783 Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
InterPro IPR014784 Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
InterPro IPR000323 Copper type II, ascorbate-dependent monooxygenase, N-terminal
InterPro IPR005018 DOMON domain
InterPro IPR000945 Dopamine-beta-monooxygenase
InterPro IPR008977 PHM/PNGase F domain
Protein Ontology PR:000006294 dopamine beta-hydroxylase
References (Earliest) J:331 Pilz A, et al., Comparative mapping of mouse chromosome 2 and human chromosome 9q: the genes for gelsolin and dopamine beta-hydroxylase map to mouse chromosome 2. Genomics. 1992 Apr;12(4):715-9
(Latest) J:208894 VanDusen NJ, et al., Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death. Dev Biol. 2014 Apr 15;388(2):149-58
All references(176)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-8801

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory