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Dcaf8 Gene Detail
Summary
  • Symbol
    Dcaf8
  • Name
    DDB1 and CUL4 associated factor 8
  • Synonyms
    D1Dau35e, D1Ucla4, H326, Wdr42a
  • Feature Type
    protein coding gene
  • IDs
    MGI:91860
    NCBI Gene: 98193
Location & Maps
more
  • Sequence Map
    Chr1:172148084-172197005 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      48922 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAN2, H326, WDR42A
  • Links
    NCBI Gene ID: 50717
    neXtProt AC: NX_Q5TAQ9

  • Chr Location
    1q23.2; chr1:160215715-160262560 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 56725
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DCAF8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DCAF8 associations

Human Disease Mouse Models
       Giant Axonal Neuropathy 2, Autosomal Dominant; GAN2   OMIM: 610100
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    102
  • Chemically induced (other)
    2
  • Gene trapped
    100
  • Genomic Mutations
    2 involving Dcaf8
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050094 VEGA Gene Model | MGI Sequence Detail 48922 C57BL/6J ±  kb
transcript OTTMUST00000127396 VEGA | MGI Sequence Detail 2754 Not Applicable  
polypeptide OTTMUSP00000068741 VEGA | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    342 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 193
    Genomic 25
    cDNA 165
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-5719, MGI:1347003, MGI:1888988, MGI:2138088, MGI:2138099, MGI:2138429, MGI:2138650
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 7
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory