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Dcaf8 Gene Detail
Summary
  • Symbol
    Dcaf8
  • Name
    DDB1 and CUL4 associated factor 8
  • Synonyms
    D1Dau35e, D1Ucla4, H326, Wdr42a
  • Feature Type
    protein coding gene
  • IDs
    MGI:91860
    NCBI Gene: 98193
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172148015-172196393 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.54 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    337 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_91860
protein coding gene Chr1:172148015-172197005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016779
protein coding gene Chr1:178002331-178054816 (+)
A/J MGP_AJ_G0016758
protein coding gene Chr1:170714816-170765262 (+)
AKR/J MGP_AKRJ_G0016724
protein coding gene Chr1:175875064-175927493 (+)
BALB/cJ MGP_BALBcJ_G0016719
protein coding gene Chr1:171262824-171312017 (+)
C3H/HeJ MGP_C3HHeJ_G0016543
protein coding gene Chr1:176450989-176500096 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017181
protein coding gene Chr1:183907297-183962904 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014887
protein coding gene Chr1:162421199-162470178 (+)
CAST/EiJ MGP_CASTEiJ_G0016123
protein coding gene Chr1:175809682-175860345 (+)
CBA/J MGP_CBAJ_G0016517
protein coding gene Chr1:190456380-190516160 (+)
DBA/2J MGP_DBA2J_G0016624
protein coding gene Chr1:169655004-169702124 (+)
FVB/NJ MGP_FVBNJ_G0016621
protein coding gene Chr1:167909965-167958261 (+)
LP/J MGP_LPJ_G0016695
protein coding gene Chr1:179092885-179146530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016648
protein coding gene Chr1:197709617-197762130 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017217
protein coding gene Chr1:175742849-175795000 (+)
PWK/PhJ MGP_PWKPhJ_G0015909
protein coding gene Chr1:169027036-169077120 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015691
protein coding gene Chr1:174687959-174745792 (+)
WSB/EiJ MGP_WSBEiJ_G0016185
protein coding gene Chr1:175894957-175950215 (+)



Homology
more
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DCAF8, DDB1 and CUL4 associated factor 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GAN2, H326, WDR42A
  • Links
    NCBI Gene ID: 50717
    neXtProt AC: NX_Q5TAQ9
    UniProt: Q5TAQ9

  • Chr Location
    1q23.2; chr1:160215715-160262560 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56725
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DCAF8
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human DCAF8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 98193 NCBI Gene Model | MGI Sequence Detail 48379 C57BL/6J ±  kb
transcript NR_151641 RefSeq | MGI Sequence Detail 3921 C57BL/6  
polypeptide Q8N7N5 UniProt | EBI | MGI Sequence Detail 591 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Molecular
Reagents
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  • All nucleic 195
    Genomic 25
    cDNA 166
    Primer pair 3
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-5719, MGI:1347003, MGI:1888988, MGI:2138088, MGI:2138099, MGI:2138429, MGI:2138650
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
  • Latest
    J:266543 Zhang YL, et al., DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory