Dcaf11 MGI Mouse Gene Detail - MGI:90168 - DDB1 and CUL4 associated factor 11

Symbol

Dcaf11
Name

DDB1 and CUL4 associated factor 11
Synonyms

0710008A13Rik, D14Ucla1, GLO14, Wdr23

Feature Type

protein coding gene
IDs

MGI:90168
NCBI Gene: 28199
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:55560006-55570065 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

4 experiments

SNPs within 2kb

109 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_90168	protein coding gene	Chr14:55559125-55570065 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021349	protein coding gene	Chr14:49593338-49603397 (+)
A/J	MGP_AJ_G0021308	protein coding gene	Chr14:48606162-48616221 (+)
AKR/J	MGP_AKRJ_G0021284	protein coding gene	Chr14:50352505-50362564 (+)
BALB/cJ	MGP_BALBcJ_G0021312	protein coding gene	Chr14:48552855-48562914 (+)
C3H/HeJ	MGP_C3HHeJ_G0021092	protein coding gene	Chr14:50039107-50049166 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021750	protein coding gene	Chr14:52087339-52097398 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019297	protein coding gene	Chr14:46979426-46989471 (+)
CAST/EiJ	MGP_CASTEiJ_G0020611	protein coding gene	Chr14:46302566-46312575 (+)
CBA/J	MGP_CBAJ_G0021059	protein coding gene	Chr14:53644853-53654912 (+)
DBA/2J	MGP_DBA2J_G0021180	protein coding gene	Chr14:48332050-48342109 (+)
FVB/NJ	MGP_FVBNJ_G0021162	protein coding gene	Chr14:47781048-47791118 (+)
LP/J	MGP_LPJ_G0021254	protein coding gene	Chr14:50639553-50649612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021186	protein coding gene	Chr14:53004369-53014439 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021777	protein coding gene	Chr14:49539950-49550009 (+)
PWK/PhJ	MGP_PWKPhJ_G0020358	protein coding gene	Chr14:44862372-44872431 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020186	protein coding gene	Chr14:45537819-45547830 (+)
WSB/EiJ	MGP_WSBEiJ_G0020664	protein coding gene	Chr14:49823366-49833437 (+)

Human Ortholog

DCAF11, DDB1 and CUL4 associated factor 11

Vertebrate Orthologs

9

Human Ortholog

DCAF11, DDB1 and CUL4 associated factor 11
Orthology source: HomoloGene, HGNC
Synonyms

GL014, PRO2389, WDR23
Links

HGNC:20258

NCBI Gene ID: 80344

neXtProt AC: NX_Q8TEB1

UniProt: Q8TEB1
Chr Location

14q12; chr14:24114697-24125242 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 11886
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DCAF11
Protein SuperFamily

WD repeat protein 23
Gene Tree

Dcaf11

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

2
Targeted

4
Genomic Mutations

1 involving Dcaf11
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

11
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dcaf11

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Dcaf11 interacts with 276 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

127
RefSeq

45
UniProt

10
CCDS

CCDS27115.1

Ensembl

ENSMUSG00000022214 (Evidence)
NCBI Gene

28199

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022214	Ensembl Gene Model \| MGI Sequence Detail	10060	C57BL/6J	± kb
transcript	ENSMUST00000117236	Ensembl \| MGI Sequence Detail	2538	Not Applicable
polypeptide	ENSMUSP00000113014	Ensembl \| MGI Sequence Detail	549	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000031241 DDB1- and CUL4-associated factor 11

(term hierarchy)
InterPro Domains

IPR020472 G-protein beta WD-40 repeat

IPR001680 WD40 repeat

IPR017986 WD40-repeat-containing domain

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

IPR017399 WD repeat protein DCAF11/LEC14B

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All nucleic 13

cDNA 12

Other 1

Microarray probesets 4

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MGD-MRK-3966, MGI:1918950, MGI:2145858

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 10
Earliest

J:15567 Warden CH, et al., Linkage mapping of 40 randomly isolated liver cDNA clones in the mouse. Genomics. 1993 Nov;18(2):295-307
Latest

J:266543 Zhang YL, et al., DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18)

TSS for Dcaf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr125767	Chr14:55559993-55560004 (+)	-7 bp
Tssr125768	Chr14:55560010-55560037 (+)	18 bp
Tssr125769	Chr14:55560480-55560528 (+)	498 bp
Tssr125770	Chr14:55560904-55560974 (+)	933 bp
Tssr125771	Chr14:55561047-55561056 (+)	1,046 bp
Tssr125772	Chr14:55561060-55561071 (+)	1,060 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/20/2020 MGI 6.16