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Acadvl Gene Detail
Summary
  • Symbol
    Acadvl
  • Name
    acyl-Coenzyme A dehydrogenase, very long chain
  • Synonyms
    VLCAD
  • Feature Type
    protein coding gene
  • IDs
    MGI:895149
    NCBI Gene: 11370
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70010183-70015411 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.96 cM, cytoband B2-B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    63 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_895149
protein coding gene Chr11:70010183-70015428 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018578
protein coding gene Chr11:70509766-70514994 (-)
A/J MGP_AJ_G0018546
protein coding gene Chr11:67835120-67840348 (-)
AKR/J MGP_AKRJ_G0018515
protein coding gene Chr11:69856306-69861533 (-)
BALB/cJ MGP_BALBcJ_G0018518
protein coding gene Chr11:68163874-68169102 (-)
C3H/HeJ MGP_C3HHeJ_G0018331
protein coding gene Chr11:69895192-69900420 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018969
protein coding gene Chr11:72626748-72631976 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016614
protein coding gene Chr11:64759436-64764618 (-)
CAST/EiJ MGP_CASTEiJ_G0017886
protein coding gene Chr11:70139023-70144245 (-)
CBA/J MGP_CBAJ_G0018303
protein coding gene Chr11:75886156-75891384 (-)
DBA/2J MGP_DBA2J_G0018413
protein coding gene Chr11:67419465-67424669 (-)
FVB/NJ MGP_FVBNJ_G0018403
protein coding gene Chr11:67066708-67071951 (-)
LP/J MGP_LPJ_G0018483
protein coding gene Chr11:71086139-71091367 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018426
protein coding gene Chr11:76480322-76485550 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019011
protein coding gene Chr11:70131450-70136678 (-)
PWK/PhJ MGP_PWKPhJ_G0017660
protein coding gene Chr11:68072372-68077621 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017450
protein coding gene Chr11:69946112-69951219 (-)
WSB/EiJ MGP_WSBEiJ_G0017940
protein coding gene Chr11:69795401-69800635 (-)



Homology
more
  • Human Ortholog
    ACADVL, acyl-CoA dehydrogenase very long chain
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ACADVL, acyl-CoA dehydrogenase very long chain
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACAD6, LCACD, VLCAD
  • Links
    NCBI Gene ID: 37
    neXtProt AC: NX_P49748
    UniProt: P49748

  • Chr Location
    17p13.1; chr17:7217125-7225267 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Acadvl mouse models; 1 with human ACADVL associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018574 Ensembl Gene Model | MGI Sequence Detail 5229 C57BL/6J ±  kb
    transcript ENSMUST00000102574 Ensembl | MGI Sequence Detail 2168 Not Applicable  
    polypeptide ENSMUSP00000099634 Ensembl | MGI Sequence Detail 656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000003604 very long-chain specific acyl-CoA dehydrogenase, mitochondrial
    • EC
    • InterPro Domains
      IPR006089 Acyl-CoA dehydrogenase, conserved site
      IPR036250 Acyl-CoA dehydrogenase-like, C-terminal
      IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
      IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
      IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily
      IPR037069 Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily
      IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
    Molecular
    Reagents
    less
    • All nucleic 277
      Genomic 4
      cDNA 271
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 6
      Diseases 4
      Gene Ontology 10
      Phenotypes 38
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:266272 Hilse KE, et al., The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart. Front Physiol. 2018;9:747

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory