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Acadvl
Gene Detail
 Symbol
Name
ID
Acadvl
acyl-Coenzyme A dehydrogenase, very long chain
MGI:895149
Synonyms VLCAD
Feature Type protein coding gene
Genetic Map
Chromosome 11
42.96 cM, cytoband B2-B5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:70010183-70015411 bp, - strand
From VEGA annotation of GRCm38

  5229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Acadvl

Human
homologs
Human Homolog ACADVL, acyl-CoA dehydrogenase, very long chain
NCBI Gene ID 37
neXtProt AC  NX_P49748
Human Synonyms  ACAD6, LCACD, VLCAD
Human Chr (Location)  17p13.1; chr17:7217125-7225267 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human ACADVL
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels.
 
Human Diseases Modeled Using Mouse Acadvl (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, ...
Component cytoplasm, membrane, ...
Function acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (179)    Tissues (117)    Images (58)
Theiler Stages: 10, 18, 22, 23, 25, 28
Assay TypeResults
RNA in situ 151
Northern blot 28
cDNA source data(270)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(276) Genomic(4) cDNA(270) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006027 (Evidence)
Ensembl Gene ModelENSMUSG00000018574 (Evidence)
Entrez Gene11370 (Evidence)
UniGene18630
DFCITC1572989, TC1600216, TC1602494
DoTSDT.101245194, DT.537490
NIA Mouse Gene IndexU158171
EC1.3.8.9
Consensus CDS ProjectCCDS24931.1
International Mouse Knockout Project StatusAcadvl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006027 VEGA Gene Model | MGI Sequence Detail 5229 C57BL/6J ±  kb
transcript OTTMUST00000013531 VEGA | MGI Sequence Detail 2168 Not Applicable 
polypeptide OTTMUSP00000006273 VEGA | MGI Sequence Detail 656 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003604 very long-chain specific acyl-CoA dehydrogenase, mitochondrial
References (Earliest) J:42861 Aoyama T, et al., A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase. Biochem Biophys Res Commun. 1993 Mar 31;191(3):1369-72
(Latest) J:199044 Tucci S, et al., Long-term dietary effects on substrate selection and muscle fiber type in very-long-chain acyl-CoA dehydrogenase deficient (VLCAD(-/-)) mice. Biochim Biophys Acta. 2013 Apr;1832(4):509-16
All references(58)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory