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Acadvl
Gene Detail
Symbol

Name
ID
Acadvl
acyl-Coenzyme A dehydrogenase, very long chain
MGI:895149
Synonyms
VLCAD
Feature Type
protein coding gene
Genetic Map
Chromosome 11
42.96 cM, cytoband B2-B5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:70010183-70015411 bp, - strand
From VEGA annotation of GRCm38

  5229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 zebrafish

HCOP human homology predictions: ACADVL
Gene Tree: Acadvl

Human
homologs
ACADVL, acyl-CoA dehydrogenase, very long chain
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 37
neXtProt AC: NX_P49748

Human Synonyms: ACAD6, LCACD, VLCAD

Human Chr (Location): 17p13.1; chr17:7217125-7225267 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human ACADVL

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Acadvl (1)
Incidental mutations (data from Mutagenetix , CvDC )
 
Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels.
 
Human Diseases Modeled in Mice Using Acadvl (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Acadvl interacts with 23 markers (Mir96, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, ...
Component cytoplasm, membrane, ...
Function acyl-CoA dehydrogenase activity, electron carrier activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (179)    Tissues (117)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 151
Northern blot 28
cDNA source data(270)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase acadvl    NEW 
Molecular
reagents
All nucleic(276) Genomic(4) cDNA(270) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000006027 (Evidence)
Ensembl Gene Model ENSMUSG00000018574 (Evidence)
Entrez Gene 11370 (Evidence)
UniGene 18630
DFCI TC1572989, TC1602494, TC1600216
DoTS DT.101245194, DT.537490
NIA Mouse Gene Index U158171
EC 1.3.8.9
Consensus CDS Project CCDS24931.1
International Mouse Phenotyping Consortium Status Acadvl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006027 VEGA Gene Model | MGI Sequence Detail 5229 C57BL/6J ±  kb
transcript OTTMUST00000013531 VEGA | MGI Sequence Detail 2168 Not Applicable 
polypeptide OTTMUSP00000006273 VEGA | MGI Sequence Detail 656 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006089 Acyl-CoA dehydrogenase, conserved site
InterPro IPR009100 Acyl-CoA dehydrogenase/oxidase
InterPro IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro IPR013786 Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain
Protein Ontology PR:000003604 very long-chain specific acyl-CoA dehydrogenase, mitochondrial
References
(Earliest) J:42861 Aoyama T, et al., A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase. Biochem Biophys Res Commun. 1993 Mar 31;191(3):1369-72
(Latest) J:221196 Schiff M, et al., Complex I assembly function and fatty acid oxidation enzyme activity of ACAD9 both contribute to disease severity in ACAD9 deficiency. Hum Mol Genet. 2015 Jun 1;24(11):3238-47
All references(62)
Disease annotation references (5)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory