Acadvl
Gene Detail

Symbol Name ID

Acadvl acyl-Coenzyme A dehydrogenase, very long chain MGI:895149

Synonyms

VLCAD

Feature Type

protein coding gene

Genetic Map

Chromosome 11

42.96 cM, cytoband B2-B5
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr11:70010183-70015411 bp, - strand From VEGA annotation of GRCm38   5229 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Acadvl ± 2 cM)

Gene Tree: Acadvl

Human ortholog

ACADVL acyl-CoA dehydrogenase, very long chain NCBI Gene ID 37
Human Synonyms: ACAD6, LCACD, VLCAD
Human Chr17:7123153-7128585 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human ACADVL (1)

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutant animals exhibit mild steatosis, lipid accumulation in myocytes, increased fatigue, impaired temperature regulation, increased susceptibility to arrhythmia, accumulation of long-chain acylcarnitines, and lower free carnitine levels.

 
Human Diseases Modeled Using Mouse Acadvl (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	fatty acid beta-oxidation, fatty acid beta-oxidation using acyl-CoA dehydrogenase, ...
Component	membrane, mitochondrial inner membrane, ...
Function	acyl-CoA dehydrogenase activity, fatty-acyl-CoA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (179)    Tissues (117)    Images (58)
Theiler Stages: 10, 18, 22, 23, 25, 28

Assay Type	Results
RNA in situ	151
Northern blot	28

cDNA source data(270)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(276) Genomic(4) cDNA(270) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006027 (Evidence)
Ensembl Gene Model	ENSMUSG00000018574 (Evidence)
Entrez Gene	11370 (Evidence)
UniGene	18630
DFCI	TC1572989, TC1600216, TC1602494
DoTS	DT.101245194, DT.537490
NIA Mouse Gene Index	U158171
EC	1.3.8.9
Consensus CDS Project	CCDS24931.1
International Mouse Knockout Project Status	Acadvl

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006027	VEGA Gene Model | MGI Sequence Detail	5229	C57BL/6J
transcript	OTTMUST00000013531	VEGA | MGI Sequence Detail	2168	Not Applicable
polypeptide	OTTMUSP00000006273	VEGA | MGI Sequence Detail	656	Not Applicable

All sequences(47) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006089	Acyl-CoA dehydrogenase, conserved site
InterPro	IPR006092	Acyl-CoA dehydrogenase, N-terminal
InterPro	IPR009100	Acyl-CoA dehydrogenase/oxidase
InterPro	IPR009075	Acyl-CoA dehydrogenase/oxidase C-terminal
InterPro	IPR013786	Acyl-CoA dehydrogenase/oxidase, N-terminal
InterPro	IPR006091	Acyl-CoA oxidase/dehydrogenase, central domain
InterPro	IPR006090	Acyl-CoA oxidase/dehydrogenase, type 1
Protein Ontology	PR:000003604	very long-chain specific acyl-CoA dehydrogenase, mitochondrial

References

(Earliest) J:42861 Aoyama T, et al., A novel disease with deficiency of mitochondrial very-long-chain acyl-CoA dehydrogenase. Biochem Biophys Res Commun. 1993 Mar 31;191(3):1369-72
(Latest) J:192050 Tucci S, et al., Tissue-specific strategies of the very-long chain acyl-CoA dehydrogenase-deficient (VLCAD-/-) mouse to compensate a defective fatty acid beta-oxidation. PLoS One. 2012;7(9):e45429
All references(57)