Lgals2 MGI Mouse Gene Detail - MGI:895068 - lectin, galactose-binding, soluble 2

Symbol

Lgals2
Name

lectin, galactose-binding, soluble 2
Synonyms

2200008F12Rik

Feature Type

protein coding gene
IDs

MGI:895068
NCBI Gene: 107753
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:78735060-78739729 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

3 experiments

SNPs within 2kb

59 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_895068	protein coding gene	Chr15:78735060-78739729 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022054	protein coding gene	Chr15:79075721-79081595 (-)
A/J	MGP_AJ_G0022015	protein coding gene	Chr15:76361424-76366091 (-)
AKR/J	MGP_AKRJ_G0021990	protein coding gene	Chr15:78476228-78480886 (-)
BALB/cJ	MGP_BALBcJ_G0022021	protein coding gene	Chr15:76330678-76335400 (-)
C3H/HeJ	MGP_C3HHeJ_G0021792	protein coding gene	Chr15:78477058-78482921 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022464	protein coding gene	Chr15:82192777-82197432 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019994	protein coding gene	Chr15:72848119-72852899 (-)
CAST/EiJ	MGP_CASTEiJ_G0021313	protein coding gene	Chr15:79166788-79173294 (-)
CBA/J	MGP_CBAJ_G0021757	protein coding gene	Chr15:84726308-84734350 (-)
DBA/2J	MGP_DBA2J_G0021886	protein coding gene	Chr15:75841198-75845824 (-)
FVB/NJ	MGP_FVBNJ_G0021864	protein coding gene	Chr15:74850505-74855831 (-)
LP/J	MGP_LPJ_G0021954	protein coding gene	Chr15:79279017-79285884 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021884	protein coding gene	Chr15:89905415-89912466 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022478	protein coding gene	Chr15:78495522-78500207 (-)
PWK/PhJ	MGP_PWKPhJ_G0021055	protein coding gene	Chr15:75839823-75844785 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020892	protein coding gene	Chr15:78282557-78287176 (-)
WSB/EiJ	MGP_WSBEiJ_G0021365	protein coding gene	Chr15:78864535-78869272 (-)

Human Ortholog

LGALS2, galectin 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGALS2, galectin 2
Synonyms

HL14
Links

HGNC:6562

NCBI Gene ID: 3957

neXtProt AC: NX_P05162

UniProt: P05162
Chr Location

22q13.1; chr22:37570246-37580017 (-) GRCh38.p7

Alliance of Genome Resources

Lgals2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LGALS2
Gene Tree

Lgals2

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References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

4
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Lgals2
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knockout allele exhibit altered leukocyte numbers, increased susceptibility to type IV hypersensitivity reaction, enhanced humoral immune response, increased colon mucin and increased spleen red pulp.

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All GO Annotations

10
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

673
Tissues

1
cDNA Data

18
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lgals2

ZFIN lgals2a, lgals2b

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Lgals2 interacts with 16 markers (Mir29b-1, Mir134, Mir182, ...) View All

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All Sequences

35
RefSeq

2
UniProt

2
CCDS

CCDS37135.1

Ensembl

ENSMUSG00000043501 (Evidence)
NCBI Gene

107753

Representative Sequences				Length	Strain/Species	Flank
	genomic	107753	NCBI Gene Model \| MGI Sequence Detail	4670	C57BL/6J	± kb

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UniProt

2 Sequences
Protein Ontology

PR:000009770 galectin-2

(term hierarchy)
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001079 Galectin, carbohydrate recognition domain

IPR044156 Galectin-like

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All nucleic 19

cDNA 18

Primer pair 1

Microarray probesets 4

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MGI:1913785, MGI:2145981

Summaries

All 58

Developmental Gene Expression 1

Diseases 1

Gene Ontology 6

Phenotypes 25
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:308429 Rehman SU, et al., Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicated in early diabetes development. Mamm Genome. 2021 Jun;32(3):153-172

TSS for Lgals2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135295	Chr15:78739898-78739939 (-)	-190 bp
Tssr135294	Chr15:78739717-78739736 (-)	2 bp
Tssr135293	Chr15:78735579-78735604 (-)	4,137 bp
Tssr135292	Chr15:78735345-78735357 (-)	4,378 bp
Tssr135291	Chr15:78735177-78735195 (-)	4,543 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/17/2022 MGI 6.19