Lgals2 MGI Mouse Gene Detail - MGI:895068 - lectin, galactose-binding, soluble 2

Lgals2 Gene Detail

Symbol

Lgals2
Name

lectin, galactose-binding, soluble 2
Synonyms

2200008F12Rik

Feature Type

protein coding gene
IDs

MGI:895068
NCBI Gene: 107753
Gene Overview

MyGene.info: LGALS2

Sequence Map

Chr15:78850862-78855529 bp, - strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

4668 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

3 experiments

Human Ortholog

LGALS2, galectin 2

Vertebrate Orthologs

8

Human Ortholog

LGALS2, galectin 2
Orthology source: HomoloGene, HGNC
Synonyms

HL14
Links

HGNC:6562

NCBI Gene ID: 3957

neXtProt AC: NX_P05162
Chr Location

22q13.1; chr22:37570246-37580017 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 4741
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: LGALS2
Protein SuperFamily

beta-galactoside-binding lectin
Gene Tree

Lgals2

Diseases

1 with human LGALS2 associations

				Human Disease	Mouse Models
				Myocardial Infarction, Susceptibility to OMIM: 608446

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Gene trapped

4
Radiation induced

2
Targeted

1
Genomic Mutations

3 involving Lgals2

Mice homozygous for a knockout allele exhibit altered leukocyte numbers, increased susceptibility to type IV hypersensitivity reaction, enhanced humoral immune response, increased colon mucin and increased spleen red pulp.

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All GO Annotations

3
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1
Tissues

1
cDNA Data

17
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase lgals2

ZFIN lgals2a, lgals2b

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Lgals2 interacts with 16 markers (Mir29b-1, Mir134, Mir182, ...) View All

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All Sequences

17
RefSeq

2
UniProt

2
CCDS

CCDS37135.1
UniGene

390793

Ensembl

ENSMUSG00000043501 (Evidence)
NCBI Gene

107753

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043501	Ensembl Gene Model \| MGI Sequence Detail	4668	C57BL/6J	± kb
transcript	ENSMUST00000044584	Ensembl \| MGI Sequence Detail	590	Not Applicable
polypeptide	ENSMUSP00000036598	Ensembl \| MGI Sequence Detail	130	Not Applicable

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SNPs within 2kb

67 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000009770 galectin-2
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain

IPR001079 Galectin, carbohydrate recognition domain

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All nucleic 18

cDNA 17

Primer pair 1

Microarray probesets 4

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MGI:1913785, MGI:2145981

Summaries

All 30

Developmental Gene Expression 1

Diseases 1

Gene Ontology 3

Phenotypes 23
Earliest

J:36694 Puche AC, et al., Role of galectin-1 in the developing mouse olfactory system. Dev Biol. 1996 Oct 10;179(1):274-87
Latest

J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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