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Lgals2 Gene Detail
Summary
  • Symbol
    Lgals2
  • Name
    lectin, galactose-binding, soluble 2
  • Synonyms
    2200008F12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:895068
    NCBI Gene: 107753
  • Gene Overview
    MyGene.info: LGALS2
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:78850860-78855529 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      4670 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.70 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LGALS2, galectin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LGALS2, galectin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HL14
  • Links
    NCBI Gene ID: 3957
    neXtProt AC: NX_P05162
    UniProt: P05162

  • Chr Location
    22q13.1; chr22:37570246-37580017 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human LGALS2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit altered leukocyte numbers, increased susceptibility to type IV hypersensitivity reaction, enhanced humoral immune response, increased colon mucin and increased spleen red pulp.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1
  • Tissues
    1
  • cDNA Data
    18
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107753 NCBI Gene Model | MGI Sequence Detail 4670 C57BL/6J ±  kb
    transcript NM_025622 RefSeq | MGI Sequence Detail 607 C57BL/6  
    polypeptide Q9CQW5 UniProt | EBI | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      67 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913785, MGI:2145981
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 23
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:249232 Akimoto Y, et al., Galectin expression in healing wounded skin treated with low-temperature plasma: Comparison with treatment by electronical coagulation. Arch Biochem Biophys. 2016 Sep 1;605:86-94
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory