Lgals2
Gene Detail

Symbol

Name
ID

Lgals2
lectin, galactose-binding, soluble 2
MGI:895068

Synonyms

2200008F12Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 15
37.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:78850862-78855529 bp, - strand From Ensembl annotation of GRCm38   4668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4741  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: beta-galactoside-binding lectin
Gene Tree: Lgals2

Human
homologs

Human Homolog		LGALS2, lectin, galactoside-binding, soluble, 2
NCBI Gene ID		3957
neXtProt AC		NX_P05162
Human Synonyms		HL14
Human Chr (Location)		22q13.1; chr22:37570246-37580017 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human LGALS2

Mutations,
alleles, and
phenotypes

All mutations/alleles(6) : Gene trapped(4) Radiation induced(1) Targeted(1)
Genomic Mutations involving Lgals2 (1)
 

Mice homozygous for a knockout allele exhibit altered leukocyte numbers, increased susceptibility to type IV hypersensitivity reaction, enhanced humoral immune response, increased colon mucin and increased spleen red pulp.

 
Phenotype Images(2)

Interactions

Lgals2 interacts with 16 markers (Mir29b-1, Mir134, Mir182, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (3 annotations)

Function

carbohydrate binding, galactoside binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (1)    Tissues (1)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	1

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(18) cDNA(17) Primer pair(1)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000043501 (Evidence)
Entrez Gene	107753 (Evidence)
UniGene	390793
DFCI	TC1572222
NIA Mouse Gene Index	U050462
Consensus CDS Project	CCDS37135.1
International Mouse Knockout Project Status	Lgals2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000043501	Ensembl Gene Model | MGI Sequence Detail	4668	C57BL/6J
transcript	ENSMUST00000044584	Ensembl | MGI Sequence Detail	590	Not Applicable
polypeptide	ENSMUSP00000036598	Ensembl | MGI Sequence Detail	130	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(67 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR001079	Galectin, carbohydrate recognition domain
Protein Ontology	PR:000009770	galectin-2

References

(Earliest) J:36694 Puche AC, et al., Role of galectin-1 in the developing mouse olfactory system. Dev Biol. 1996 Oct 10;179(1):274-87
(Latest) J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80
All references(33)

Other
accession IDs

MGI:1913785, MGI:2145981