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Uty Gene Detail
Summary
  • Symbol
    Uty
  • Name
    ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
  • Synonyms
    Hydb
  • Feature Type
    protein coding gene
  • IDs
    MGI:894810
    NCBI Gene: 22290
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrY:1096861-1245759 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome Y, Syntenic
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    95 from dbSNP Build 142
  • Strain Annotations
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894810
 protein coding gene ChrY:1085187-1245787 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    UTY, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UTY, ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
  • Synonyms
    KDM6AL, KDM6C, UTY1
  • Links
    NCBI Gene ID: 7404
    neXtProt AC: NX_O14607
    UniProt: O14607

  • Chr Location
    Yq11.221; chrY:13233895-13480673 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    12 phenotype references
Mutant male mice hemizygous for a gene trapped allele are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    776
  • Tissues
    45
  • cDNA Data
    37
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000068457 Ensembl Gene Model | MGI Sequence Detail 148899 C57BL/6J ±  kb
transcript ENSMUST00000069309 Ensembl | MGI Sequence Detail 5208 Not Applicable  
polypeptide ENSMUSP00000070012 Ensembl | MGI Sequence Detail 1212 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    13 Sequences
  • EC
    1.14.11.68
  • InterPro Domains
    IPR003347 JmjC domain
    IPR048562 Lysine-specific demethylase 6A/B-like, C-terminal helical domain
    IPR048560 Lysine-specific demethylase 6A/B-like, GATA-like
    IPR046941 Lysine-specific demethylase 6, GATA-like domain superfamily
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
Molecular
Reagents
less
  • All nucleic 48
    Genomic 5
    cDNA 37
    Primer pair 6

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11034, MGI:96299
References
more
  • Summaries
    All 52
    Developmental Gene Expression 16
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:21470 King TR, et al., Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics. 1994 Nov 1;24(1):159-68
  • Latest
    J:333188 Koizumi M, et al., UTX deficiency in neural stem/progenitor cells results in impaired neural development, fetal ventriculomegaly, and postnatal death. FASEB J. 2022 Dec;36(12):e22662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory