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Unc5b
Gene Detail
Symbol

Name
ID
Unc5b
unc-5 homolog B (C. elegans)
MGI:894703
Synonyms
6330415E02Rik, D10Bwg0792e, Unc5h2
Feature Type
protein coding gene
Genetic Map
Chromosome 10
31.52 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:60762610-60831581 bp, - strand
From Ensembl annotation of GRCm38

  68972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UNC5B
Protein SuperFamily: unc-5 protein
Gene Tree: Unc5b

Human
homologs
UNC5B, unc-5 netrin receptor B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 219699
neXtProt AC: NX_Q8IZJ1

Human Synonyms: p53RDL1, UNC5H2

Human Chr (Location): 10q22.1; chr10:71212535-71302879 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a severely hypomorphic allele exhibit background sensitive lethality during organogenesis.
 
Interactions
Unc5b interacts with 246 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anterior/posterior axon guidance, apoptotic process, ...
Component integral component of membrane, membrane, ...
Function netrin receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (30 records)
Data Summary: Results (308)    Tissues (60)    Images (70)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 286
RT-PCR 9
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase unc5b ; ZFIN unc5b    NEW 
Molecular
reagents
All nucleic(55) cDNA(51) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000020099 (Evidence)
Entrez Gene 107449 (Evidence)
UniGene 290433
DFCI TC1606985, TC1580876
DoTS DT.101198192, DT.101346160, DT.60104941, DT.110586254
NIA Mouse Gene Index U031832
PDB 1WMG
Consensus CDS Project CCDS23872.1
International Mouse Phenotyping Consortium Status Unc5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020099 Ensembl Gene Model | MGI Sequence Detail 68972 C57BL/6J ±  kb
transcript ENSMUST00000077925 Ensembl | MGI Sequence Detail 5852 Not Applicable 
polypeptide ENSMUSP00000077080 Ensembl | MGI Sequence Detail 945 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(408 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR000906 ZU5
Protein Ontology PR:000017094 netrin receptor UNC5B
References
(Earliest) J:16042 Doherty TM, et al., Modulation of murine macrophage function by IL-13. J Immunol. 1993 Dec 15;151(12):7151-60
(Latest) J:218226 Seiradake E, et al., FLRT structure: balancing repulsion and cell adhesion in cortical and vascular development. Neuron. 2014 Oct 22;84(2):370-85
All references(78)
Other
accession IDs
MGD-MRK-34085, MGI:106392, MGI:1924103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory