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Unc5b
Gene Detail
 Symbol
Name
ID
Unc5b
unc-5 homolog B (C. elegans)
MGI:894703
Synonyms 6330415E02Rik, D10Bwg0792e, Unc5h2
Feature Type protein coding gene
Genetic Map
Chromosome 10
31.52 cM, cytoband B4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:60762610-60831581 bp, - strand
From Ensembl annotation of GRCm38

  68972 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32538  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: unc-5 protein
Gene Tree: Unc5b

Human
homologs
Human Homolog UNC5B, unc-5 homolog B (C. elegans)
NCBI Gene ID 219699
neXtProt AC  NX_Q8IZJ1
Human Synonyms  p53RDL1, UNC5H2
Human Chr (Location)  10q22.1; chr10:71212535-71302878 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(9) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a severely hypomorphic allele exhibit background sensitive lethality during organogenesis.
 
Interactions
Unc5b interacts with 247 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process anterior/posterior axon guidance, apoptotic process, ...
Component integral component of membrane, membrane, ...
Function netrin receptor activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (28 records)
Data Summary: Results (308)    Tissues (60)    Images (70)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 286
RT-PCR 9
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(51) Primer pair(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020099 (Evidence)
Entrez Gene107449 (Evidence)
UniGene290433
DFCITC1580876, TC1606985
DoTSDT.101198192, DT.101346160, DT.110586254, DT.60104941
NIA Mouse Gene IndexU031832
PDB1WMG
Consensus CDS ProjectCCDS23872.1
International Mouse Knockout Project StatusUnc5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020099 Ensembl Gene Model | MGI Sequence Detail 68972 C57BL/6J ±  kb
transcript ENSMUST00000077925 Ensembl | MGI Sequence Detail 5852 Not Applicable 
polypeptide ENSMUSP00000077080 Ensembl | MGI Sequence Detail 945 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(6) UniProt(4)
Polymorphisms SNPs within 2kb(408 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000488 Death domain
InterPro IPR011029 Death-like domain
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR000906 ZU5
Protein Ontology PR:000017094 netrin receptor UNC5B
References (Earliest) J:16042 Doherty TM, et al., Modulation of murine macrophage function by IL-13. J Immunol. 1993 Dec 15;151(12):7151-60
(Latest) J:203268 Kohler D, et al., The uncoordinated-5 homolog B (UNC5B) receptor increases myocardial ischemia-reperfusion injury. PLoS One. 2013;8(7):e69477
All references(77)
Other
accession IDs
MGD-MRK-34085, MGI:106392, MGI:1924103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory