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Unc5b Gene Detail
Summary
  • Symbol
    Unc5b
  • Name
    unc-5 netrin receptor B
  • Synonyms
    6330415E02Rik, D10Bwg0792e, Unc5h2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894703
    NCBI Gene: 107449
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:60762594-60831581 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 31.52 cM, cytoband B4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    408 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894703
protein coding gene Chr10:60762593-60831598 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017272
protein coding gene Chr10:60024274-60100113 (-)
A/J MGP_AJ_G0017250
protein coding gene Chr10:58253246-58324945 (-)
AKR/J MGP_AKRJ_G0017210
protein coding gene Chr10:59775496-59844154 (-)
BALB/cJ MGP_BALBcJ_G0017210
protein coding gene Chr10:58332982-58405584 (-)
C3H/HeJ MGP_C3HHeJ_G0017033
protein coding gene Chr10:59677024-59750835 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017668
protein coding gene Chr10:62163260-62235829 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015359
protein coding gene Chr10:55235347-55304558 (-)
CAST/EiJ MGP_CASTEiJ_G0016604
protein coding gene Chr10:59651277-59728497 (-)
CBA/J MGP_CBAJ_G0017005
protein coding gene Chr10:64451293-64526693 (-)
DBA/2J MGP_DBA2J_G0017110
protein coding gene Chr10:57542656-57613619 (-)
FVB/NJ MGP_FVBNJ_G0017104
protein coding gene Chr10:56788715-56867197 (-)
LP/J MGP_LPJ_G0017185
protein coding gene Chr10:60436409-60511732 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017132
protein coding gene Chr10:66858223-66932384 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017706
protein coding gene Chr10:59574224-59649336 (-)
PWK/PhJ MGP_PWKPhJ_G0016387
protein coding gene Chr10:57364902-57436632 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016170
protein coding gene Chr10:58911867-58982252 (-)
WSB/EiJ MGP_WSBEiJ_G0016668
protein coding gene Chr10:59501943-59576125 (-)



Homology
more
  • Human Ortholog
    UNC5B, unc-5 netrin receptor B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UNC5B, unc-5 netrin receptor B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    p53RDL1, UNC5H2
  • Links
    NCBI Gene ID: 219699
    neXtProt AC: NX_Q8IZJ1
    UniProt: Q8IZJ1

  • Chr Location
    10q22.1; chr10:71212535-71302879 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a severely hypomorphic allele exhibit background sensitive lethality during organogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 107449 NCBI Gene Model | MGI Sequence Detail 68988 C57BL/6J ±  kb
    transcript NM_029770 RefSeq | MGI Sequence Detail 5884 C57BL/6  
    polypeptide Q8K1S3 UniProt | EBI | MGI Sequence Detail 945 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 53
      Primer pair 5

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34085, MGI:106392, MGI:1924103
    References
    more
    • Summaries
      All 92
      Developmental Gene Expression 34
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:242901 Tai-Nagara I, et al., Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017 Jul 01;144(13):2392-2401

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/12/2019
    MGI 6.14
    The Jackson Laboratory