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Numbl Gene Detail
Summary
  • Symbol
    Numbl
  • Name
    numb-like
  • Synonyms
    nbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894702
    NCBI Gene: 18223
  • Gene Overview
    MyGene.info: NUMBL
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27258433-27282144 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 15.86 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894702
protein coding gene Chr7:27258433-27282150 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031905
protein coding gene Chr7:25887248-25911899 (+)
A/J MGP_AJ_G0031884
protein coding gene Chr7:25276527-25303437 (+)
AKR/J MGP_AKRJ_G0031814
protein coding gene Chr7:25940924-25964619 (+)
BALB/cJ MGP_BALBcJ_G0031889
protein coding gene Chr7:25496344-25520030 (+)
C3H/HeJ MGP_C3HHeJ_G0031611
protein coding gene Chr7:26326295-26349592 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032354
protein coding gene Chr7:26740197-26768853 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029406
protein coding gene Chr7:26511171-26534777 (+)
CAST/EiJ MGP_CASTEiJ_G0030946
protein coding gene Chr7:19625737-19649314 (+)
CBA/J MGP_CBAJ_G0031576
protein coding gene Chr7:27920531-27947722 (+)
DBA/2J MGP_DBA2J_G0031728
protein coding gene Chr7:25073933-25098791 (+)
FVB/NJ MGP_FVBNJ_G0031684
protein coding gene Chr7:25159076-25186050 (+)
LP/J MGP_LPJ_G0031808
protein coding gene Chr7:26225295-26248723 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031719
protein coding gene Chr7:27518629-27543613 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032385
protein coding gene Chr7:25475826-25503536 (+)
PWK/PhJ MGP_PWKPhJ_G0030670
protein coding gene Chr7:20107517-20133386 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030504
protein coding gene Chr7:16464738-16489488 (+)
WSB/EiJ MGP_WSBEiJ_G0031054
protein coding gene Chr7:25766725-25792209 (+)



Homology
more
  • Human Ortholog
    NUMBL, NUMB like, endocytic adaptor protein
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NUMBL, NUMB like, endocytic adaptor protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAG3A, CTG3a, NBL, NUMBLIKE, NUMBR, NUMB-R, TNRC23
  • Links
    NCBI Gene ID: 9253
    neXtProt AC: NX_Q9Y6R0
    UniProt: Q9Y6R0

  • Chr Location
    19q13.2; chr19:40665905-40690658 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    35 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit no overt phenotypes except for a reduction in female fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063160 Ensembl Gene Model | MGI Sequence Detail 23712 C57BL/6J ±  kb
    transcript ENSMUST00000079258 Ensembl | MGI Sequence Detail 2760 Not Applicable  
    polypeptide ENSMUSP00000078245 Ensembl | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 2
      cDNA 41
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:41027 Zhong W, et al., Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development. 1997 May;124(10):1887-97
    • Latest
      J:241571 Lin YT, et al., Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. Development. 2017 May 01;144(9):1607-1618

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory