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Numbl Gene Detail
Summary
  • Symbol
    Numbl
  • Name
    numb-like
  • Synonyms
    nbl
  • Feature Type
    protein coding gene
  • IDs
    MGI:894702
    NCBI Gene: 18223
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26957884-26981570 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.86 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    655 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894702
 protein coding gene Chr7:26957858-26981570 (+)
129S1/SvImJ ENSMUSG00200041581
 protein coding gene Chr7:16754777-16779115 (+)
A/J ENSMUSG00195050012
 protein coding gene Chr7:19399944-19424700 (+)
AKR/J ENSMUSG00220047653
 protein coding gene Chr7:25061335-25086025 (-)
BALB/cJ ENSMUSG00180052502
 protein coding gene Chr7:17465142-17489902 (+)
C3H/HeJ ENSMUSG00175049836
 protein coding gene Chr7:18515962-18540303 (+)
C57BL/6NJ ENSMUSG00215054768
 protein coding gene Chr7:16647037-16671805 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029406
 protein coding gene Chr7:26511171-26534777 (+)
CAST/EiJ ENSTCUG00005047459
 protein coding gene Chr7:18455714-18480666 (+)
CBA/J ENSMUSG00210052305
 protein coding gene Chr7:17701474-17725821 (+)
DBA/2J ENSMUSG00185050395
 protein coding gene Chr7:20808889-20833655 (+)
FVB/NJ ENSMUSG00205029291
 protein coding gene Chr7:17490630-17514970 (+)
JF1/MsJ ENSUMUG00000048750
 protein coding gene Chr7:25244414-25269295 (+)
LP/J ENSMUSG00230053472
 protein coding gene Chr7:25980754-26005083 (+)
NOD/ShiLtJ ENSMUSG00190033353
 protein coding gene Chr7:17143120-17167875 (+)
NZO/HlLtJ ENSMUSG00225023073
 protein coding gene Chr7:24857586-24882348 (+)
PWK/PhJ ENSLUMG00010036335
 protein coding gene Chr7:17173481-17198691 (+)
SPRET/EiJ ENSMSPG00010050596
 protein coding gene Chr7:16556504-16581141 (+)
WSB/EiJ ENSIUOG00005050925
 protein coding gene Chr7:11400721-11425042 (+)



Homology
more
  • Human Ortholog
    NUMBL, NUMB like endocytic adaptor protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUMBL, NUMB like endocytic adaptor protein
  • Synonyms
    CAG3A, CTG3a, NBL, NUMBLIKE, NUMB-R, NUMBR, TNRC23
  • Links
    NCBI Gene ID: 9253
    UniProt: Q9Y6R0

  • Chr Location
    19q13.2; chr19:40665905-40690972 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    35 phenotypes from multigenic genotypes
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and exhibit no overt phenotypes except for a reduction in female fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    75
  • cDNA Data
    40
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18223 NCBI Gene Model | MGI Sequence Detail 23687 C57BL/6J ±  kb
    transcript NM_001417032 RefSeq | MGI Sequence Detail 2807 C57BL/6  
    polypeptide O08919 UniProt | EBI | MGI Sequence Detail 604 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 2
      cDNA 42
      Primer pair 1
      Other 2
      Antibodies 4

      Microarray probesets 2
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 13
      Gene Ontology 14
      Phenotypes 45
    • Earliest
      J:41027 Zhong W, et al., Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development. 1997 May;124(10):1887-97
    • Latest
      J:377760 Nusrat A, et al., Invasion of Epicardial-Derived Cells to the Trabeculae Mediated by NFPs-Fgf Signaling Regulates Ventricular Compaction. Circ Heart Fail. 2026 Jan 1;:e013210
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory