Sgca
Gene Detail

Symbol Name ID

Sgca sarcoglycan, alpha (dystrophin-associated glycoprotein) MGI:894698

Synonyms

50DAG, adhalin, Asg

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.01 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:94962791-94976327 bp, - strand From VEGA annotation of GRCm38   13537 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:9  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: sarcoglycan, alpha/epsilon types
Gene Tree: Sgca

Human homologs

Human Homolog		SGCA, sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
NCBI Gene ID		6442
neXtProt AC		NX_Q16586
Human Synonyms		50-DAG, A2, adhalin, ADL, DAG2, DMDA2, LGMD2D, SCARMD1
Human Chr (Location)		17q21; chr17:48243366-48253293 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SGCA

Alleles and phenotypes

All alleles(9) : Targeted(7) Gene trapped(2)
 

Homozygous mutation of this gene results in muscle abnormalities, with decreased skeletal muscle force and stiffness and muscular dystrophy.

 
Human Diseases Modeled Using Mouse Sgca (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cellular membrane organization
Component	cell-cell junction, cytoplasm, ...
Function	calcium ion binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (36)    Tissues (22)    Images (1)
Theiler Stages: 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	13
Northern blot	13
Western blot	2
RT-PCR	8

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(16) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000001503 (Evidence)
Ensembl Gene Model	ENSMUSG00000001508 (Evidence)
Entrez Gene	20391 (Evidence)
UniGene	18709
DFCI	TC1583979
DoTS	DT.485149
NIA Mouse Gene Index	U033295
Consensus CDS Project	CCDS25266.1
International Mouse Knockout Project Status	Sgca

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001503	VEGA Gene Model | MGI Sequence Detail	13537	C57BL/6J
transcript	OTTMUST00000002975	VEGA | MGI Sequence Detail	1724	Not Applicable
polypeptide	OTTMUSP00000001460	VEGA | MGI Sequence Detail	387	Not Applicable

All sequences(37) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015919	Cadherin-like
InterPro	IPR006644	Dystroglycan-type cadherin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR008908	Sarcoglycan alphaepsilon
Protein Ontology	PR:000014781	alpha-sarcoglycan

References

(Earliest) J:3426 Matsumura K, et al., Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle. Nature. 1992 Dec 10;360(6404):588-91
(Latest) J:190189 Buono R, et al., Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP. Stem Cells. 2012 Feb;30(2):197-209
All references(63)