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Sgca
Gene Detail
Symbol

Name
ID
Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
MGI:894698
Synonyms
50DAG, adhalin, Asg
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.01 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:94962791-94976327 bp, - strand
From VEGA annotation of GRCm38

  13537 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SGCA
Protein SuperFamily: sarcoglycan, alpha/epsilon types
Gene Tree: Sgca

Human
homologs
SGCA, sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6442
neXtProt AC: NX_Q16586

Human Synonyms: 50-DAG, A2, adhalin, ADL, DAG2, DMDA2, LGMD2D, SCARMD1

Human Chr (Location): 17q21; chr17:50165975-50175932 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SGCA

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(2) Targeted(10)
Genomic Mutations involving Sgca (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in muscle abnormalities, with decreased skeletal muscle force and stiffness and muscular dystrophy.
 
Human Diseases Modeled in Mice Using Sgca (1)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Sgca interacts with 54 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process membrane organization
Component cell-cell junction, cytoplasm, ...
Function calcium ion binding
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (35)    Tissues (22)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
Northern blot 12
Western blot 2
RT-PCR 8
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sgca    NEW 
Molecular
reagents
All nucleic(12) Genomic(2) cDNA(7) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000001503 (Evidence)
Ensembl Gene Model ENSMUSG00000001508 (Evidence)
Entrez Gene 20391 (Evidence)
DFCI TC1583979
DoTS DT.485149
NIA Mouse Gene Index U033295
Consensus CDS Project CCDS25266.1
International Mouse Phenotyping Consortium Status Sgca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001503 VEGA Gene Model | MGI Sequence Detail 13537 C57BL/6J ±  kb
transcript OTTMUST00000002975 VEGA | MGI Sequence Detail 1724 Not Applicable 
polypeptide OTTMUSP00000001460 VEGA | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(154 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015919 Cadherin-like
InterPro IPR006644 Dystroglycan-type cadherin-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR008908 Sarcoglycan alphaepsilon
Protein Ontology PR:000014781 alpha-sarcoglycan
References
(Earliest) J:3426 Matsumura K, et al., Association of dystrophin-related protein with dystrophin-associated proteins in mdx mouse muscle. Nature. 1992 Dec 10;360(6404):588-91
(Latest) J:216209 Roque-Ramirez B, et al., Expression pattern of mRNA A and mRNA B of alpha sarcoglycan gene during mouse embryonic development and regulation of their expression by myogenic and cardiogenic transcription factors. Dev Dyn. 2014 Nov;243(11):1416-28
All references(68)
Disease annotation references (6)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory