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Rad54l Gene Detail
Summary
  • Symbol
    Rad54l
  • Name
    RAD54 like (S. cerevisiae)
  • Synonyms
    RAD54
  • Feature Type
    protein coding gene
  • IDs
    MGI:894697
    NCBI Gene: 19366
Location & Maps
more
  • Sequence Map
    Chr4:116094264-116123690 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29427 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RAD54L, RAD54-like (S. cerevisiae)
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAD54L, RAD54-like (S. cerevisiae)
    Orthology source: HomoloGene
  • Synonyms
    hHR54, HR54, hRAD54, RAD54A
  • Links
    NCBI Gene ID: 8438
    neXtProt AC: NX_Q92698

  • Chr Location
    1p32; chr1:46247695-46278473 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human RAD54L associations

Human Disease Mouse Models
       Breast Cancer   OMIM: 114480
Lymphoma, Non-Hodgkin, Familial   OMIM: 605027
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    2
  • Gene trapped
    17
  • Radiation induced
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Rad54l
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008554 VEGA Gene Model | MGI Sequence Detail 29427 C57BL/6J ±  kb
transcript OTTMUST00000019396 VEGA | MGI Sequence Detail 2780 Not Applicable  
polypeptide OTTMUSP00000008903 VEGA | MGI Sequence Detail 747 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000013680 DNA repair and recombination protein RAD54-like
  • EC
  • InterPro Domains
    IPR001650 Helicase, C-terminal
    IPR014001 Helicase superfamily 1/2, ATP-binding domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000330 SNF2-related, N-terminal domain
Molecular
Reagents
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  • All nucleic 11
    Genomic 1
    cDNA 10

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 35
  • Earliest
    J:34999 Kanaar R, et al., Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. Curr Biol. 1996 Jul 1;6(7):828-38
  • Latest
    J:204015 Tanori M, et al., Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum. Stem Cells. 2013 Nov;31(11):2506-16

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory