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Rad54l
Gene Detail
 Symbol
Name
ID
Rad54l
RAD54 like (S. cerevisiae)
MGI:894697
Synonyms RAD54
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:116094264-116123690 bp, - strand
From VEGA annotation of GRCm38

  29427 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48227  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rad54l

Human
homologs
Human Homolog RAD54L, RAD54-like (S. cerevisiae)
NCBI Gene ID 8438
neXtProt AC  NX_Q92698
Human Synonyms  hHR54, HR54, hRAD54, RAD54A
Human Chr (Location)  1p32; chr1:46247695-46278473 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human RAD54L
Alleles
and
phenotypes
All alleles(20) : Gene trapped(17) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have an increased sensitivity to crosslinking agents and to ionizing radiation but outherwise have a normal phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular response to DNA damage stimulus, chromosome organization, ...
Component nucleus
Function annealing helicase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (95)    Tissues (12)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 95
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000008554 (Evidence)
Ensembl Gene ModelENSMUSG00000028702 (Evidence)
Entrez Gene19366 (Evidence)
EC3.6.4.-
Consensus CDS ProjectCCDS18504.1
International Mouse Knockout Project StatusRad54l
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008554 VEGA Gene Model | MGI Sequence Detail 29427 C57BL/6J ±  kb
transcript OTTMUST00000019396 VEGA | MGI Sequence Detail 2780 Not Applicable 
polypeptide OTTMUSP00000008903 VEGA | MGI Sequence Detail 747 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(109 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR013967 Rad54, N-terminal
InterPro IPR000330 SNF2-related
Protein Ontology PR:000013680 DNA repair and recombination protein RAD54-like
References (Earliest) J:34999 Kanaar R, et al., Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. Curr Biol. 1996 Jul 1;6(7):828-38
(Latest) J:204015 Tanori M, et al., Developmental and oncogenic radiation effects on neural stem cells and their differentiating progeny in mouse cerebellum. Stem Cells. 2013 Nov;31(11):2506-16
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/01/2014
MGI 5.18
The Jackson Laboratory