Serping1
Gene Detail

Symbol Name ID

Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 MGI:894696

Synonyms

C1INH, C1 inhibitor, C1nh

Feature Type

protein coding gene

Genetic Map

Chromosome 2

49.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:84765387-84775444 bp, - strand From VEGA annotation of GRCm38   10058 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:44  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Serping1

Human homologs

Human Homolog		SERPING1, serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Gene ID		710
neXtProt AC		NX_P05155
Human Synonyms		C1IN, C1INH, C1NH, HAE1, HAE2
Human Chr (Location)		11q12.1; chr11:57365027-57382326 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SERPING1

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(7)
 

Mutant mice exhibit an increased vascular permeability compared to controls.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	blood coagulation, complement activation, classical pathway, ...
Component	extracellular region, extracellular space
Function	complement binding, peptidase inhibitor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (17)    Tissues (17)    Images (5)
Theiler Stages: 17, 21, 22

Assay Type	Results
RNA in situ	17

cDNA source data(251)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(254) Genomic(2) cDNA(251) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000013680 (Evidence)
Ensembl Gene Model	ENSMUSG00000023224 (Evidence)
Entrez Gene	12258 (Evidence)
UniGene	38888
DFCI	TC1574684, TC1656931
DoTS	DT.496174, DT.99840821
NIA Mouse Gene Index	U022817
Consensus CDS Project	CCDS16193.1
International Mouse Knockout Project Status	Serping1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013680	VEGA Gene Model | MGI Sequence Detail	10058	C57BL/6J
transcript	OTTMUST00000032823	VEGA | MGI Sequence Detail	1768	Not Applicable
polypeptide	OTTMUSP00000014647	VEGA | MGI Sequence Detail	504	Not Applicable

All sequences(33) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(79 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015553	Protease inhibitor I4, serpin C1
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014707	plasma protease C1 inhibitor

References

(Earliest) J:40775 Russell JA, et al., The sequence of a cDNA encoding functional murine C1-inhibitor protein. Biochim Biophys Acta. 1997 May 30;1352(2):156-60
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(43)