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Serping1 Gene Detail
Summary
  • Symbol
    Serping1
  • Name
    serine (or cysteine) peptidase inhibitor, clade G, member 1
  • Synonyms
    C1INH, C1 inhibitor, C1nh
  • Feature Type
    protein coding gene
  • IDs
    MGI:894696
    NCBI Gene: 12258
  • Gene Overview
    MyGene.info: SERPING1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84765387-84775444 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894696
protein coding gene Chr2:84765360-84775444 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025910
protein coding gene Chr2:85455494-85465401 (-)
A/J MGP_AJ_G0025884
protein coding gene Chr2:82151028-82160877 (-)
AKR/J MGP_AKRJ_G0025854
protein coding gene Chr2:84268351-84280032 (-)
BALB/cJ MGP_BALBcJ_G0025881
protein coding gene Chr2:82284257-82294274 (-)
C3H/HeJ MGP_C3HHeJ_G0025640
protein coding gene Chr2:84511582-84523404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026327
protein coding gene Chr2:88103439-88114381 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023729
protein coding gene Chr2:78976910-78986912 (-)
CAST/EiJ MGP_CASTEiJ_G0025101
protein coding gene Chr2:85041066-85052585 (-)
CBA/J MGP_CBAJ_G0025621
protein coding gene Chr2:91254185-91266535 (-)
DBA/2J MGP_DBA2J_G0025752
protein coding gene Chr2:81689507-81699376 (-)
FVB/NJ MGP_FVBNJ_G0025715
protein coding gene Chr2:80945646-80956754 (-)
LP/J MGP_LPJ_G0025840
protein coding gene Chr2:85253508-85265172 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025745
protein coding gene Chr2:93574759-93586353 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026383
protein coding gene Chr2:84505673-84521639 (-)
PWK/PhJ MGP_PWKPhJ_G0024845
protein coding gene Chr2:81531251-81541611 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024649
protein coding gene Chr2:84644646-84654496 (-)
WSB/EiJ MGP_WSBEiJ_G0025171
protein coding gene Chr2:85173216-85183949 (-)



Homology
more
  • Human Ortholog
    SERPING1, serpin family G member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SERPING1, serpin family G member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C1IN, C1INH, C1NH, HAE1, HAE2
  • Links
    NCBI Gene ID: 710
    neXtProt AC: NX_P05155
    UniProt: P05155

  • Chr Location
    11q12.1; chr11:57597554-57614853 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SERPING1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutant mice exhibit an increased vascular permeability compared to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023224 Ensembl Gene Model | MGI Sequence Detail 10058 C57BL/6J ±  kb
    transcript ENSMUST00000023994 Ensembl | MGI Sequence Detail 1768 Not Applicable  
    polypeptide ENSMUSP00000023994 Ensembl | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 256
      Genomic 2
      cDNA 253
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:40775 Russell JA, et al., The sequence of a cDNA encoding functional murine C1-inhibitor protein. Biochim Biophys Acta. 1997 May 30;1352(2):156-60
    • Latest
      J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory