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Serping1
Gene Detail
 Symbol
Name
ID
Serping1
serine (or cysteine) peptidase inhibitor, clade G, member 1
MGI:894696
Synonyms C1INH, C1 inhibitor, C1nh
Feature Type protein coding gene
Genetic Map
Chromosome 2
49.45 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:84765387-84775444 bp, - strand
From VEGA annotation of GRCm38

  10058 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:44  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Serping1

Human
homologs
Human Homolog SERPING1, serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
NCBI Gene ID 710
neXtProt AC  NX_P05155
Human Synonyms  C1IN, C1INH, C1NH, HAE1, HAE2
Human Chr (Location)  11q12.1; chr11:57597554-57614853 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SERPING1
Alleles
and
phenotypes
All alleles(10) : Targeted(3) Gene trapped(7)
 
Mutant mice exhibit an increased vascular permeability compared to controls.
 
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process blood coagulation, complement activation, classical pathway, ...
Component blood microparticle, extracellular region, ...
Function complement binding, peptidase inhibitor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (17)    Tissues (17)    Images (5)
Theiler Stages: 17, 21, 22
Assay TypeResults
RNA in situ 17
cDNA source data(252)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(255) Genomic(2) cDNA(252) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000013680 (Evidence)
Ensembl Gene ModelENSMUSG00000023224 (Evidence)
Entrez Gene12258 (Evidence)
UniGene38888
DFCITC1574684, TC1656931
DoTSDT.496174, DT.99840821
NIA Mouse Gene IndexU022817
Consensus CDS ProjectCCDS16193.1
International Mouse Knockout Project StatusSerping1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013680 VEGA Gene Model | MGI Sequence Detail 10058 C57BL/6J ±  kb
transcript OTTMUST00000032823 VEGA | MGI Sequence Detail 1768 Not Applicable 
polypeptide OTTMUSP00000014647 VEGA | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(82 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015553 Protease inhibitor I4, serpin C1
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014707 plasma protease C1 inhibitor
References (Earliest) J:40775 Russell JA, et al., The sequence of a cDNA encoding functional murine C1-inhibitor protein. Biochim Biophys Acta. 1997 May 30;1352(2):156-60
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory