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Galnt1
Gene Detail
Symbol

Name
ID
Galnt1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
MGI:894693
Synonyms
ppGaNTase-T1
Feature Type
protein coding gene
Genetic Map
Chromosome 18
12.90 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:24205344-24286818 bp, + strand
From VEGA annotation of GRCm38

  81475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8469  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GALNT1
Gene Tree: Galnt1

Human
homologs
GALNT1, polypeptide N-acetylgalactosaminyltransferase 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2589
neXtProt AC: NX_Q10472

Human Synonyms: GALNAC-T1

Human Chr (Location): 18q12.1; chr18:35627436-35711834 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(131) : Gene trapped(126) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit some embryonic lethality, increased bleeding time, decreased T and B cells, impaired leukocyte rolling, decreased IgG levels, and hypoalbuminemia.
 
Interactions
Galnt1 interacts with 317 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process protein O-linked glycosylation, protein O-linked glycosylation via serine, ...
Component extracellular region, Golgi apparatus, ...
Function carbohydrate binding, manganese ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (346)    Tissues (162)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 346
cDNA source data(184)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GALNT1 ; Xenbase galnt1 ; ZFIN galnt1    NEW 
Molecular
reagents
All nucleic(185) cDNA(184) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036067 (Evidence)
Ensembl Gene Model ENSMUSG00000000420 (Evidence)
Entrez Gene 14423 (Evidence)
UniGene 30249
DFCI TC1576325, TC1709834, TC1708657, TC1650558, TC1733759
DoTS DT.101282522, DT.94237277, DT.101403460
NIA Mouse Gene Index U043650
EC 2.4.1.41
PDB 1XHB
Consensus CDS Project CCDS29100.1
International Mouse Phenotyping Consortium Status Galnt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036067 VEGA Gene Model | MGI Sequence Detail 81475 C57BL/6J ±  kb
transcript OTTMUST00000092647 VEGA | MGI Sequence Detail 3977 Not Applicable 
polypeptide OTTMUSP00000051261 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(447 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001173 Glycosyl transferase, family 2
InterPro IPR000772 Ricin B lectin domain
Protein Ontology PR:000007818 polypeptide N-acetylgalactosaminyltransferase 1
References
(Earliest) J:40489 Hagen FK, et al., cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1997 May 23;272(21):13843-8
(Latest) J:188733 Block H, et al., Severe impairment of leukocyte recruitment in ppGalNAcT-1-deficient mice. J Immunol. 2012 Jun 1;188(11):5674-81
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory