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Galnt1
Gene Detail
 Symbol
Name
ID
Galnt1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1
MGI:894693
Synonyms ppGaNTase-T1
Feature Type protein coding gene
Genetic Map
Chromosome 18
12.90 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr18:24205344-24286818 bp, + strand
From VEGA annotation of GRCm38

  81475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8469  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Galnt1

Human
homologs
Human Homolog GALNT1, polypeptide N-acetylgalactosaminyltransferase 1
NCBI Gene ID 2589
neXtProt AC  NX_Q10472
Human Synonyms  GALNAC-T1
Human Chr (Location)  18q12.1; chr18:35627436-35711834 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(131) : Gene trapped(126) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some embryonic lethality, increased bleeding time, decreased T and B cells, impaired leukocyte rolling, decreased IgG levels, and hypoalbuminemia.
 
Interactions
Galnt1 interacts with 317 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process protein O-linked glycosylation, protein O-linked glycosylation via serine, ...
Component extracellular region, Golgi apparatus, ...
Function manganese ion binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (346)    Tissues (162)    Images (50)
Theiler Stages: 11, 13, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 346
cDNA source data(184)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(185) cDNA(184) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000036067 (Evidence)
Ensembl Gene ModelENSMUSG00000000420 (Evidence)
Entrez Gene14423 (Evidence)
UniGene30249
DFCITC1576325, TC1650558, TC1708657, TC1709834, TC1733759
DoTSDT.101282522, DT.101403460, DT.94237277
NIA Mouse Gene IndexU043650
EC2.4.1.41
PDB1XHB
Consensus CDS ProjectCCDS29100.1
International Mouse Knockout Project StatusGalnt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036067 VEGA Gene Model | MGI Sequence Detail 81475 C57BL/6J ±  kb
transcript OTTMUST00000092647 VEGA | MGI Sequence Detail 3977 Not Applicable 
polypeptide OTTMUSP00000051261 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(5)
Polymorphisms SNPs within 2kb(447 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001173 Glycosyl transferase, family 2
InterPro IPR000772 Ricin B lectin domain
Protein Ontology PR:000007818 polypeptide N-acetylgalactosaminyltransferase 1
References (Earliest) J:40489 Hagen FK, et al., cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase. J Biol Chem. 1997 May 23;272(21):13843-8
(Latest) J:188733 Block H, et al., Severe impairment of leukocyte recruitment in ppGalNAcT-1-deficient mice. J Immunol. 2012 Jun 1;188(11):5674-81
All references(46)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory