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Serpinb6b
Gene Detail
Symbol

Name
ID
Serpinb6b
serine (or cysteine) peptidase inhibitor, clade B, member 6b
MGI:894688
Synonyms
NK13, ovalbumin, Spi12
Feature Type
protein coding gene
Genetic Map
Chromosome 13
13.78 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr13:32965209-32979067 bp, + strand
From VEGA annotation of GRCm38

  13859 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22633  Vertebrate Homology Class
1 mouse; 1 rat

Protein SuperFamily: serpin
Gene Tree: Serpinb6b

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Radiation induced(1) Targeted(2)
Genomic Mutations involving Serpinb6b (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Serpinb6b interacts with 183 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process gonad development, negative regulation of endopeptidase activity
Component cytoplasm, extracellular space, ...
Function serine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (105)    Tissues (23)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
RT-PCR 7
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) Genomic(2) cDNA(39) Primer pair(3) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000000698 (Evidence)
Ensembl Gene Model ENSMUSG00000042842 (Evidence)
Entrez Gene 20708 (Evidence)
UniGene 36526
DFCI TC1642087, TC1580589
DoTS DT.91447895, DT.110975521
NIA Mouse Gene Index U014708
Consensus CDS Project CCDS26430.1
International Mouse Phenotyping Consortium Status Serpinb6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000698 VEGA Gene Model | MGI Sequence Detail 13859 C57BL/6J ±  kb
transcript OTTMUST00000001331 VEGA | MGI Sequence Detail 2193 Not Applicable 
polypeptide OTTMUSP00000000628 VEGA | MGI Sequence Detail 377 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(49 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
References
(Earliest) J:41085 Sun J, et al., A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9). J Biol Chem. 1997 Jun 13;272(24):15434-41
(Latest) J:213076 Kaiserman D, et al., Identification of Serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A. J Biol Chem. 2014 Mar 28;289(13):9408-17
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory