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Pa2g4 Gene Detail
Summary
  • Symbol
    Pa2g4
  • Name
    proliferation-associated 2G4
  • Synonyms
    Ebp1, Plfap
  • Feature Type
    protein coding gene
  • IDs
    MGI:894684
    NCBI Gene: 18813
  • Gene Overview
    MyGene.info: PA2G4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:128557766-128565934 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.09 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894684
protein coding gene Chr10:128557766-128565987 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017872
protein coding gene Chr10:132311313-132319481 (-)
A/J MGP_AJ_G0017847
protein coding gene Chr10:126998091-127006259 (-)
AKR/J MGP_AKRJ_G0017810
protein coding gene Chr10:130715094-130723481 (-)
BALB/cJ MGP_BALBcJ_G0017811
protein coding gene Chr10:127371913-127380081 (-)
C3H/HeJ MGP_C3HHeJ_G0017634
protein coding gene Chr10:130877813-130885979 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018266
protein coding gene Chr10:136790705-136798873 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015944
protein coding gene Chr10:120919238-120926426 (-)
CAST/EiJ MGP_CASTEiJ_G0017195
protein coding gene Chr10:131591749-131603011 (-)
CBA/J MGP_CBAJ_G0017604
protein coding gene Chr10:142353074-142361232 (-)
DBA/2J MGP_DBA2J_G0017710
protein coding gene Chr10:126055432-126063600 (-)
FVB/NJ MGP_FVBNJ_G0017705
protein coding gene Chr10:124977523-124986525 (-)
LP/J MGP_LPJ_G0017784
protein coding gene Chr10:132898236-132906390 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017733
protein coding gene Chr10:144936423-144944591 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018306
protein coding gene Chr10:130817954-130826122 (-)
PWK/PhJ MGP_PWKPhJ_G0016980
protein coding gene Chr10:126315880-126324096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016769
protein coding gene Chr10:129930462-129938584 (-)
WSB/EiJ MGP_WSBEiJ_G0017254
protein coding gene Chr10:131034849-131043019 (-)



Homology
more
  • Human Ortholog
    PA2G4, proliferation-associated 2G4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PA2G4, proliferation-associated 2G4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EBP1, HG4-1, p38-2G4
  • Links
    NCBI Gene ID: 5036
    neXtProt AC: NX_Q9UQ80
    UniProt: Q9UQ80

  • Chr Location
    12q13.2; chr12:56104319-56113910 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased body size and weight during early adulthood and produce smaller than normal litters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18813 NCBI Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
    transcript NM_011119 RefSeq | MGI Sequence Detail 2432 C57BL/6  
    polypeptide P50580 UniProt | EBI | MGI Sequence Detail 394 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 23
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2143505
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:29067 Radomski N, et al., Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle. Exp Cell Res. 1995 Oct;220(2):434-45
    • Latest
      J:245070 Karlsson T, et al., A polybasic motif in ErbB3-binding protein 1 (EBP1) has key functions in nucleolar localization and polyphosphoinositide interaction. Biochem J. 2016 Jul 15;473(14):2033-47

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    07/09/2019
    MGI 6.14
    The Jackson Laboratory