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Pa2g4
Gene Detail
 Symbol
Name
ID
Pa2g4
proliferation-associated 2G4
MGI:894684
Synonyms Ebp1, Plfap
Feature Type protein coding gene
Genetic Map
Chromosome 10
77.09 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:128557766-128565934 bp, - strand
From VEGA annotation of GRCm38

  8169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: methionine aminopeptidase
Gene Tree: Pa2g4

Human
homologs
Human Homolog PA2G4, proliferation-associated 2G4, 38kDa
NCBI Gene ID 5036
neXtProt AC  NX_Q9UQ80
Human Synonyms  EBP1, HG4-1, p38-2G4
Human Chr (Location)  12q13.2; chr12:56104319-56113910 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit decreased body size and weight during early adulthood and produce smaller than normal litters.
 
Phenotype Images(1)
Interactions
Pa2g4 interacts with 199 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process negative regulation of transcription, DNA-templated, regulation of transcription, DNA-templated, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function DNA binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (9)    Tissues (9)    Images (1)
Theiler Stages: 15, 17, 19, 22, 24
Assay TypeResults
RNA in situ 9
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000024830 (Evidence)
Ensembl Gene ModelENSMUSG00000025364 (Evidence)
Entrez Gene18813 (Evidence)
DFCITC1572030, TC1608055, TC1640680, TC1669347
DoTSDT.101715161, DT.101739632, DT.101739633, DT.495947, DT.91342767, DT.99863680
NIA Mouse Gene IndexU032364
PDB2V6C
Consensus CDS ProjectCCDS24282.1
International Mouse Knockout Project StatusPa2g4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024830 VEGA Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript OTTMUST00000061152 VEGA | MGI Sequence Detail 2432 Not Applicable 
polypeptide OTTMUSP00000029937 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018349 Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
InterPro IPR000994 Peptidase M24, structural domain
InterPro IPR004545 Proliferation-associated protein 1
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012202 proliferation-associated protein 2G4
References (Earliest) J:29067 Radomski N, et al., Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle. Exp Cell Res. 1995 Oct;220(2):434-45
(Latest) J:184831 Uchibe K, et al., Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012 Jul;241(7):1217-26
All references(48)
Other
accession IDs
MGI:2143505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory