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Pa2g4
Gene Detail
Symbol

Name
ID
Pa2g4
proliferation-associated 2G4
MGI:894684
Synonyms
Ebp1, Plfap
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.09 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:128557766-128565934 bp, - strand
From VEGA annotation of GRCm38

  8169 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4513  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PA2G4
Protein SuperFamily: methionine aminopeptidase
Gene Tree: Pa2g4

Human
homologs
PA2G4, proliferation-associated 2G4, 38kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5036
neXtProt AC: NX_Q9UQ80

Human Synonyms: EBP1, HG4-1, p38-2G4

Human Chr (Location): 12q13.2; chr12:56104319-56113910 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(17) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit decreased body size and weight during early adulthood and produce smaller than normal litters.
 
Phenotype Images(1)
Interactions
Pa2g4 interacts with 198 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process negative regulation of apoptotic process, negative regulation of transcription, DNA-templated, ...
Component cytoplasm, extracellular exosome, ...
Function DNA binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (9)    Tissues (9)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 9
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pa2g4 ; ZFIN pa2g4a, pa2g4b    NEW 
Molecular
reagents
All nucleic(22) cDNA(22)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000024830 (Evidence)
Ensembl Gene Model ENSMUSG00000025364 (Evidence)
Entrez Gene 18813 (Evidence)
DFCI TC1572030, TC1608055, TC1669347, TC1640680
DoTS DT.99863680, DT.91342767, DT.101715161, DT.495947, DT.101739633, DT.101739632
NIA Mouse Gene Index U032364
PDB 2V6C
Consensus CDS Project CCDS24282.1
International Mouse Phenotyping Consortium Status Pa2g4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024830 VEGA Gene Model | MGI Sequence Detail 8169 C57BL/6J ±  kb
transcript OTTMUST00000061152 VEGA | MGI Sequence Detail 2432 Not Applicable 
polypeptide OTTMUSP00000029937 VEGA | MGI Sequence Detail 394 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(100 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018349 Peptidase M24A, methionine aminopeptidase, subfamily 2, binding site
InterPro IPR000994 Peptidase M24, structural domain
InterPro IPR004545 Proliferation-associated protein 1
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000012202 proliferation-associated protein 2G4
References
(Earliest) J:29067 Radomski N, et al., Molecular cloning of a murine cDNA encoding a novel protein, p38-2G4, which varies with the cell cycle. Exp Cell Res. 1995 Oct;220(2):434-45
(Latest) J:206597 Figeac N, et al., ErbB3 binding protein-1 (Ebp1) controls proliferation and myogenic differentiation of muscle stem cells. Dev Biol. 2014 Feb 1;386(1):135-51
All references(49)
Other
accession IDs
MGI:2143505

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory