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Usp9x
Gene Detail
Symbol

Name
ID
Usp9x
ubiquitin specific peptidase 9, X chromosome
MGI:894681
Synonyms
5730589N07Rik, Dffrx, Fafl
Feature Type
protein coding gene
Genetic Map
Chromosome X
7.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:13071498-13173328 bp, + strand
From VEGA annotation of GRCm38

  101831 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

HCOP human homology predictions: USP9X
Gene Tree: Usp9x

Human
homologs
USP9X, ubiquitin specific peptidase 9, X-linked
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8239
neXtProt AC: NX_Q93008

Human Synonyms: DFFRX, FAF, FAM, MRX99

Human Chr (Location): Xp11.4; chrX:41085433-41236579 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human USP9X

Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(63) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
In a conditional model of pancreatic ductal carcinoma, hemizygous males and heterozygous females with a conditional allele exhibit accelerated tumorigenesis.
 
Phenotype Images(13)
Interactions
Usp9x interacts with 504 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process axon extension, BMP signaling pathway, ...
Component apical part of cell, cell projection, ...
Function co-SMAD binding, cysteine-type endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (186)    Tissues (123)    Images (66)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 43
RNA in situ 89
Northern blot 14
Western blot 6
RT-PCR 34
cDNA source data(280)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase usp9x ; ZFIN usp9    NEW 
Molecular
reagents
All nucleic(283) cDNA(282) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000017076 (Evidence)
Ensembl Gene Model ENSMUSG00000031010 (Evidence)
Entrez Gene 22284 (Evidence)
UniGene 242646
DFCI TC1622539, TC1613745, TC1628308, TC1572338
DoTS DT.91355995, DT.55172996, DT.110574642, DT.103578655, DT.91382831
NIA Mouse Gene Index U019721, U057437, U353015, U148223
EC 3.4.19.12
Consensus CDS Project CCDS40875.1
International Mouse Phenotyping Consortium Status Usp9x
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017076 VEGA Gene Model | MGI Sequence Detail 101831 C57BL/6J ±  kb
transcript OTTMUST00000041347 VEGA | MGI Sequence Detail 11887 Not Applicable 
polypeptide OTTMUSP00000055164 VEGA | MGI Sequence Detail 2554 Not Applicable 

For the selected sequences
All sequences(92) RefSeq(20) UniProt(8)
Polymorphisms
SNPs within 2kb(188 from dbSNP Build 137)    SNPs within 2kb including multiple locations(190)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000029846 ubiquitin carboxyl-terminal hydrolase FAF-X
References
(Earliest) J:39118 Crozet F, et al., Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. 1997 Mar 1;40(2):332-41
(Latest) J:218690 Naik E, et al., Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X. J Exp Med. 2014 Sep 22;211(10):1947-55
All references(61)
Other
accession IDs
MGI:1353594, MGI:1924266, MGI:2147163, MGI:2147940, MGI:2147941

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory