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Usp9x
Gene Detail
 Symbol
Name
ID
Usp9x
ubiquitin specific peptidase 9, X chromosome
MGI:894681
Synonyms 5730589N07Rik, Dffrx, Fafl
Feature Type protein coding gene
Genetic Map
Chromosome X
7.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:13071498-13173328 bp, + strand
From VEGA annotation of GRCm38

  101831 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3418  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Usp9x

Human
homologs
Human Homolog USP9X, ubiquitin specific peptidase 9, X-linked
NCBI Gene ID 8239
neXtProt AC  NX_Q93008
Human Synonyms  DFFRX, FAF, FAM, MRX99
Human Chr (Location)  Xp11.4; chrX:41085615-41236579 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human USP9X
Mutations,
alleles, and
phenotypes
All mutations/alleles(67) : Gene trapped(63) Targeted(4)
Incidental mutations (data from APF )
 
In a conditional model of pancreatic ductal carcinoma, hemizygous males and heterozygous females with a conditional allele exhibit accelerated tumorigenesis.
 
Phenotype Images(13)
Interactions
Usp9x interacts with 505 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process axon extension, BMP signaling pathway, ...
Component apical part of cell, cytoplasm, ...
Function co-SMAD binding, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (135)    Tissues (98)    Images (24)
Theiler Stages: 10, 11, 15, 17, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 75
Northern blot 14
RT-PCR 34
cDNA source data(280)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(283) cDNA(282) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000017076 (Evidence)
Ensembl Gene ModelENSMUSG00000031010 (Evidence)
Entrez Gene22284 (Evidence)
UniGene242646
DFCITC1572338, TC1613745, TC1622539, TC1628308
DoTSDT.103578655, DT.110574642, DT.55172996, DT.91355995, DT.91382831
NIA Mouse Gene IndexU019721, U057437, U148223, U353015
EC3.4.19.12
Consensus CDS ProjectCCDS40875.1
International Mouse Knockout Project StatusUsp9x
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017076 VEGA Gene Model | MGI Sequence Detail 101831 C57BL/6J ±  kb
transcript OTTMUST00000041347 VEGA | MGI Sequence Detail 11887 Not Applicable 
polypeptide OTTMUSP00000055164 VEGA | MGI Sequence Detail 2554 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(18) UniProt(8)
Polymorphisms SNPs within 2kb(188 from dbSNP Build 137)    SNPs within 2kb including multiple locations(190)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2
InterPro IPR018200 Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2, conserved site
Protein Ontology PR:000029846 ubiquitin carboxyl-terminal hydrolase FAF-X
References (Earliest) J:39118 Crozet F, et al., Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. 1997 Mar 1;40(2):332-41
(Latest) J:211314 Homan CC, et al., Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth. Am J Hum Genet. 2014 Mar 6;94(3):470-8
All references(61)
Other
accession IDs
MGI:1353594, MGI:1924266, MGI:2147163, MGI:2147940, MGI:2147941

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory