About   Help   FAQ
Bach1 Gene Detail
Summary
  • Symbol
    Bach1
  • Name
    BTB and CNC homology 1, basic leucine zipper transcription factor 1
  • Synonyms
    6230421P05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894680
    NCBI Gene: 12013
  • Gene Overview
    MyGene.info: BACH1
Location & Maps
more
  • Sequence Map
    Chr16:87698945-87733346 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34402 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 49.84 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BACH1, BTB domain and CNC homolog 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BACH1, BTB domain and CNC homolog 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BACH-1, BTBD24
  • Links
    NCBI Gene ID: 571
    neXtProt AC: NX_O14867

  • Chr Location
    21q22.11; chr21:29298795-29361896 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 916
    1 human;1 mouse;2 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: BACH1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Gene trapped
    42
  • Targeted
    8
  • Genomic Mutations
    2 involving Bach1
  • Incidental Mutations
Homozygous null mice are healthy and fertile with no gross abnormalities but express elevated levels of HMOX1.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026479 VEGA Gene Model | MGI Sequence Detail 34402 C57BL/6J ±  kb
transcript OTTMUST00000065469 VEGA | MGI Sequence Detail 5867 Not Applicable  
polypeptide OTTMUSP00000032635 VEGA | MGI Sequence Detail 739 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    278 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004617 transcription regulator protein BACH1
  • PDB
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR000210 BTB/POZ domain
    IPR011333 SKP1/BTB/POZ domain
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
less
  • All nucleic 71
    cDNA 68
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGI:1923386, MGI:2146411
References
more
  • Summaries
    All 62
    Developmental Gene Expression 12
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
  • Latest
    J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory