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Bach1
Gene Detail
Symbol

Name
ID
Bach1
BTB and CNC homology 1
MGI:894680
Synonyms
6230421P05Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 16
49.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:87698945-87733346 bp, + strand
From VEGA annotation of GRCm38

  34402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:916  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: BACH1
Gene Tree: Bach1

Human
homologs
BACH1, BTB and CNC homology 1, basic leucine zipper transcription factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 571
neXtProt AC: NX_O14867

Human Synonyms: BACH-1, BTBD24

Human Chr (Location): 21q22.11; chr21:29298795-29361896 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(42) Targeted(7)
Genomic Mutations involving Bach1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are healthy and fertile with no gross abnormalities but express elevated levels of HMOX1.
 
Interactions
Bach1 interacts with 375 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process DNA repair, negative regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, cytosol, ...
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (243)    Tissues (210)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 204
Northern blot 12
RT-PCR 27
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA BACH1 ; Xenbase bach1 ; ZFIN bach1b    NEW 
Molecular
reagents
All nucleic(71) cDNA(68) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000026479 (Evidence)
Ensembl Gene Model ENSMUSG00000025612 (Evidence)
Entrez Gene 12013 (Evidence)
UniGene 26147
DFCI TC1584234, TC1634908, TC1614019, TC1603849
DoTS DT.529376, DT.55182972, DT.532941
NIA Mouse Gene Index U017337
PDB 2Z8H
Consensus CDS Project CCDS28293.1
International Mouse Phenotyping Consortium Status Bach1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026479 VEGA Gene Model | MGI Sequence Detail 34402 C57BL/6J ±  kb
transcript OTTMUST00000065469 VEGA | MGI Sequence Detail 5867 Not Applicable 
polypeptide OTTMUSP00000032635 VEGA | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000004617 transcription regulator protein BACH1
References
(Earliest) J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
(Latest) J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
All references(63)
Other
accession IDs
MGI:1923386, MGI:2146411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory