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Bach1
Gene Detail
 Symbol
Name
ID
Bach1
BTB and CNC homology 1
MGI:894680
Synonyms 6230421P05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 16
49.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:87698945-87733346 bp, + strand
From VEGA annotation of GRCm38

  34402 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:916  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Bach1

Human
homologs
Human Homolog BACH1, BTB and CNC homology 1, basic leucine zipper transcription factor 1
NCBI Gene ID 571
neXtProt AC  NX_O14867
Human Synonyms  BACH-1, BTBD24
Human Chr (Location)  21q22.11; chr21:29298804-29411809 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(49) : Gene trapped(42) Targeted(7)
Genomic Mutations involving Bach1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are healthy and fertile with no gross abnormalities but express elevated levels of HMOX1.
 
Interactions
Bach1 interacts with 376 markers (Mir7-1, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process negative regulation of transcription from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, ...
Component cytosol, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (243)    Tissues (210)    Images (23)
Theiler Stages: 2, 3, 4, 5, 13, 15, 16, 17, 19, 20, 21, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 204
Northern blot 12
RT-PCR 27
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) cDNA(68) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026479 (Evidence)
Ensembl Gene ModelENSMUSG00000025612 (Evidence)
Entrez Gene12013 (Evidence)
UniGene26147
DFCITC1584234, TC1603849, TC1614019, TC1634908
DoTSDT.529376, DT.532941, DT.55182972
NIA Mouse Gene IndexU017337
PDB2Z8H
Consensus CDS ProjectCCDS28293.1
International Mouse Knockout Project StatusBach1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026479 VEGA Gene Model | MGI Sequence Detail 34402 C57BL/6J ±  kb
transcript OTTMUST00000065469 VEGA | MGI Sequence Detail 5867 Not Applicable 
polypeptide OTTMUSP00000032635 VEGA | MGI Sequence Detail 739 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(280 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000004617 transcription regulator protein BACH1
References (Earliest) J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
(Latest) J:210804 Haldar M, et al., Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages. Cell. 2014 Mar 13;156(6):1223-34
All references(63)
Other
accession IDs
MGI:1923386, MGI:2146411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory