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Bach2 Gene Detail
Summary
  • Symbol
    Bach2
  • Name
    BTB and CNC homology, basic leucine zipper transcription factor 2
  • Synonyms
    E030004N02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:894679
    NCBI Gene: 12014
  • Gene Overview
    MyGene.info: BACH2
Location & Maps
more
  • Sequence Map
    Chr4:32238804-32586104 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      347301 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 14.02 cM, cytoband A4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    BACH2, BTB domain and CNC homolog 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BACH2, BTB domain and CNC homolog 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BTBD25
  • Links
    NCBI Gene ID: 60468
    neXtProt AC: NX_Q9BYV9

  • Chr Location
    6q15; chr6:89926528-90296908 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7240
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: BACH2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 4 alleles in 4 genetic backgrounds
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically and radiation induced
    1
  • Chemically induced (ENU)
    2
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    1 involving Bach2
  • Incidental Mutations
    APF
Homozygous null mice display impaired B cell differentiation and reduced B cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004927 VEGA Gene Model | MGI Sequence Detail 347301 C57BL/6J ±  kb
transcript OTTMUST00000010964 VEGA | MGI Sequence Detail 8882 Not Applicable  
polypeptide OTTMUSP00000005120 VEGA | MGI Sequence Detail 839 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1745 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004618 transcription regulator protein BACH2
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR000210 BTB/POZ domain
    IPR029845 Nuclear factor erythroid 2-related factor 2
    IPR011333 SKP1/BTB/POZ domain
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain
Molecular
Reagents
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  • All nucleic 59
    cDNA 58
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2442959
References
more
  • Summaries
    All 51
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 25
  • Earliest
    J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
  • Latest
    J:231228 Tanaka H, et al., Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3. J Biol Chem. 2016 Mar 18;291(12):6316-30

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory