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Bach2
Gene Detail
Symbol

Name
ID
Bach2
BTB and CNC homology 2
MGI:894679
Synonyms
E030004N02Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 4
14.02 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:32238804-32586104 bp, + strand
From VEGA annotation of GRCm38

  347301 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7240  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BACH2
Gene Tree: Bach2

Human
homologs
BACH2, BTB and CNC homology 1, basic leucine zipper transcription factor 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 60468
neXtProt AC: NX_Q9BYV9

Human Synonyms: BTBD25

Human Chr (Location): 6q15; chr6:89926528-90296908 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Gene trapped(3) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mice display impaired B cell differentiation and reduced B cell numbers.
 
Interactions
Bach2 interacts with 513 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (210)    Tissues (124)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
Northern blot 12
Western blot 4
RT-PCR 8
cDNA source data(57)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bach2    NEW 
Molecular
reagents
All nucleic(59) cDNA(58) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000004927 (Evidence)
Ensembl Gene Model ENSMUSG00000040270 (Evidence)
Entrez Gene 12014 (Evidence)
UniGene 491223
DFCI TC1602851, TC1605924, TC1595089, TC1586015, TC1715536
DoTS DT.55235768, DT.40141525, DT.110821861, DT.103560705, DT.101371260
Consensus CDS Project CCDS51135.1
International Mouse Phenotyping Consortium Status Bach2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000004927 VEGA Gene Model | MGI Sequence Detail 347301 C57BL/6J ±  kb
transcript OTTMUST00000010964 VEGA | MGI Sequence Detail 8882 Not Applicable 
polypeptide OTTMUSP00000005120 VEGA | MGI Sequence Detail 839 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(13) UniProt(4)
Polymorphisms
SNPs within 2kb(1758 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR013069 BTB/POZ
InterPro IPR011333 BTB/POZ fold
InterPro IPR000210 BTB/POZ-like
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
Protein Ontology PR:000004618 transcription regulator protein BACH2
References
(Earliest) J:41872 Oyake T, et al., Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. Mol Cell Biol. 1996 Nov;16(11):6083-95
(Latest) J:213161 Kuwahara M, et al., The Menin-Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis. Nat Commun. 2014;5:3555
All references(48)
Other
accession IDs
MGI:2442959

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory